Search Results - "Patel, Ami V."

Insertional Mutagenesis Identifies a STAT3/Arid1b/β-catenin Pathway Driving Neurofibroma Initiation by Wu, Jianqiang, Keng, Vincent W., Patmore, Deanna M., Kendall, Jed J., Patel, Ami V., Jousma, Edwin, Jessen, Walter J., Choi, Kwangmin, Tschida, Barbara R., Silverstein, Kevin A.T., Fan, Danhua, Schwartz, Eric B., Fuchs, James R., Zou, Yuanshu, Kim, Mi-Ok, Dombi, Eva, Levy, David E., Huang, Gang, Cancelas, Jose A., Stemmer-Rachamimov, Anat O., Spinner, Robert J., Largaespada, David A., Ratner, Nancy

“…To identify genes and signaling pathways that initiate Neurofibromatosis type 1 (NF1) neurofibromas, we used unbiased insertional mutagenesis screening, mouse…”
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BDNF is required for the survival of differentiated geniculate ganglion neurons by Patel, Ami V., Krimm, Robin F.

“…In mice lacking functional brain-derived neurotrophic factor (BDNF), the number of geniculate ganglion neurons, which innervate taste buds, is reduced by…”
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Neurotrophin-4 regulates the survival of gustatory neurons earlier in development using a different mechanism than brain-derived neurotrophic factor by Patel, Ami V., Krimm, Robin F.

“…The number of neurons in the geniculate ganglion that are available to innervate taste buds is regulated by neurotrophin-4 (NT-4) and brain-derived…”
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Fatty acid synthase is a metabolic oncogene targetable in malignant peripheral nerve sheath tumors by Patel, Ami V, Johansson, Gunnar, Colbert, Melissa C, Dasgupta, Biplab, Ratner, Nancy

“…Malignant peripheral nerve sheath tumors (MPNSTs) are soft tissue sarcomas with minimal therapeutic opportunities. We observed that lipid droplets (LDs)…”
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Lingual and palatal gustatory afferents each depend on both BDNF and NT-4, but the dependence is greater for lingual than palatal afferents by Patel, Ami V., Huang, Tao, Krimm, Robin F.

“…Neurons of the geniculate ganglion innervate taste buds located in two spatially distinct targets, the tongue and palate. About 50% of these neurons die in…”
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An ShRNA Screen Identifies MEIS1 as a Driver of Malignant Peripheral Nerve Sheath Tumors by Patel, Ami V., Chaney, Katherine E., Choi, Kwangmin, Largaespada, David A., Kumar, Ashish R., Ratner, Nancy

“…Malignant peripheral nerve sheath tumors (MPNST) are rare soft tissue sarcomas that are a major source of mortality in neurofibromatosis type 1 (NF1) patients…”
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Providing Palliative Care to Patients Throughout the State of Indiana from a Centralized Virtual Palliative Care Hub by Shepard, Eric N., Patel, Ami V., Countryman, Shannon, Kara, Areeba, Sinha, Shilpee

“…Access to palliative care clinicians is a limited resource. Expanding the reach of existing palliative care expertise by utilizing virtual care is one strategy…”
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Cdkn2a Loss in a Model of Neurofibroma Demonstrates Stepwise Tumor Progression to Atypical Neurofibroma and MPNST by Chaney, Katherine E, Perrino, Melissa R, Kershner, Leah J, Patel, Ami V, Wu, Jianqiang, Choi, Kwangmin, Rizvi, Tilat A, Dombi, Eva, Szabo, Sara, Largaespada, David A, Ratner, Nancy

“…Plexiform neurofibromas are benign nerve sheath Schwann cell tumors characterized by biallelic mutations in the neurofibromatosis type 1 (NF1) tumor suppressor…”
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Ras-Driven Transcriptome Analysis Identifies Aurora Kinase A as a Potential Malignant Peripheral Nerve Sheath Tumor Therapeutic Target by PATEL, Ami V, EAVES, David, MILLER, Shyra J, RATNER, Nancy, JESSEN, Walter J, RIZVI, Tilat A, ECSEDY, Jeffrey A, QIAN, Mark G, ARONOW, Bruce J, PERENTESIS, John P, SERRA, Eduard, CRIPE, Timothy P

“…Patients with neurofibromatosis type 1 (NF1) develop malignant peripheral nerve sheath tumors (MPNST), which are often inoperable and do not respond well to…”
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Aurora A kinase inhibition enhances oncolytic herpes virotherapy through cytotoxic synergy and innate cellular immune modulation by Currier, Mark A, Sprague, Les, Rizvi, Tilat A, Nartker, Brooke, Chen, Chun-Yu, Wang, Pin-Yi, Hutzen, Brian J, Franczek, Meghan R, Patel, Ami V, Chaney, Katherine E, Streby, Keri A, Ecsedy, Jeffrey A, Conner, Joe, Ratner, Nancy, Cripe, Timothy P

“…Malignant peripheral nerve sheath tumor (MPNST) and neuroblastoma models respond to the investigational small molecule Aurora A kinase inhibitor, alisertib. We…”
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CK2 blockade causes MPNST cell apoptosis and promotes degradation of β-catenin by Kendall, Jed J, Chaney, Katherine E, Patel, Ami V, Rizvi, Tilat A, Largaespada, David A, Ratner, Nancy

“…Malignant peripheral nerve sheath tumors (MPNSTs) are soft tissue sarcomas that are a major cause of mortality of Neurofibromatosis type 1 (NF1) patients…”
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Polo-like kinase 1 as a therapeutic target for malignant peripheral nerve sheath tumors (MPNST) and schwannomas by Guo, Jianman, Chaney, Katherine E, Choi, Kwangmin, Witek, Gabriela, Patel, Ami V, Xie, Hong, Lin, Danny, Whig, Kanupriya, Xiong, Yao, Schultz, David C, Ratner, Nancy, Field, Jeffrey

“…Neurofibromatosis type 1 (NF1) and Neurofibromatosis type 2 (NF2) are two dominantly inherited disorders that cause tumors in Schwann cells. NF1 patients have…”
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Care of Patients at the End of Life: Surrogate Decision Making for Incapacitated Patients by Patel, Ami V, Ackermann, Richard J

“…Competence is determined by a court of law, whereas physicians determine medical decision-making capacity (DMC). When patients lack DMC, a surrogate should be…”
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Discovery of a small molecule targeting IRA2 deletion in budding yeast and neurofibromin loss in malignant peripheral nerve sheath tumor cells by Wood, Matthew, Rawe, Melissa, Johansson, Gunnar, Pang, Shu, Soderquist, Ryan S, Patel, Ami V, Nelson, Sandra, Seibel, William, Ratner, Nancy, Sanchez, Yolanda

“…Malignant peripheral nerve sheath tumor (MPNST) is a life-threatening complication of neurofibromatosis type 1 (NF1). NF1 is caused by mutation in the gene…”
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EGFR–STAT3 signaling promotes formation of malignant peripheral nerve sheath tumors by Wu, J, Patmore, D M, Jousma, E, Eaves, D W, Breving, K, Patel, A V, Schwartz, E B, Fuchs, J R, Cripe, T P, Stemmer-Rachamimov, A O, Ratner, N

“…Malignant peripheral nerve sheath tumors (MPNSTs) develop sporadically or in the context of neurofibromatosis type 1. Epidermal growth factor receptor (EGFR)…”
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BDNF and NT-4 each employ distinct mechanisms to regulate development of the geniculate ganglion by Patel, Ami V

“…Neurons of the geniculate ganglion innervate taste buds located in the tongue and the palate. About 50% of these neurons die in bdnf -/- as well as nt-4-/-…”
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BDNF and NT-4 each employ distinct mechanisms to regulate development of the geniculate ganglion by Patel, Ami V

“…Neurons of the geniculate ganglion innervate taste buds located in the tongue and the palate. About 50% of these neurons die in bdnf -/- as well as nt-4-/-…”
Get full text