Search Results - "Patat, A"

The Effect of Safinamide, a Novel Drug for Parkinson's Disease, on Pressor Response to Oral Tyramine: A Randomized, Double-Blind, Clinical Trial by Marquet, A, Kupas, K, Johne, A, Astruc, B, Patat, A, Krösser, S, Kovar, A

“…This randomized, double‐blind, placebo‐, comparator (selegiline 10 mg/day)‐, and positive (phenelzine 30 mg/day)‐controlled study investigated the pressor…”
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AL-335, a Once-Daily Pangenotypic Nucleotide HCV Polymerase Inhibitor, Demonstrates Potent Antiviral Activity over 7 Days in Treatment-Naïve Genotype 1-4 Patients by Berliba, E, Tsertsvadze, T, Ghicavii, N, Guyader, D, Kakabadze, T, Westland, C, Chanda, S, Patat, A, Zhang, Q, Smith, D, Yogaratnam, J, McClure, M, Beigelman, L, Blatt, L, Fry, J

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A Positron Emission Tomography Study to Assess Binding of Lecozotan, a Novel 5‐Hydroxytryptamine‐1A Silent Antagonist, to Brain 5‐HT1A Receptors in Healthy Young and Elderly Subjects, and in Patients With Alzheimer's Disease by Raje, S, Patat, A A, Parks, V, Schechter, L, Plotka, A, Paul, J, Langstrom, B

“…This positron emission tomography (PET) study was conducted to assess binding of lecozotan, a new potent and silent 5‐hydroxytryptamine‐1A (5‐HT1A) antagonist…”
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Free-flow electrophoresis for top-down proteomics by Fourier transform ion cyclotron resonance mass spectrometry by Ouvry-Patat, Séverine A, Torres, Matthew P, Quek, Hung-Hiang, Gelfand, Craig A, O'Mullan, Patrick, Nissum, Mikkel, Schroeder, Gottfried K, Han, Jun, Elliott, Monica, Dryhurst, Deanna, Ausio, Juan, Wolfenden, Richard, Borchers, Christoph H

“…High-efficiency prefractionation of complex protein mixtures is critical for top-down proteomics, i.e., the analysis of intact proteins by MS. Free-flow…”
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Pharmacokinetic interactions of OBE001 and betamethasone in healthy female volunteers by Pohl, O., Homery, M.-C., Lemaux, F., Patat, A., Chollet, A.

“…Summary What is known and objective To treat preterm labour, antenatal corticosteroids and tocolytics are often co‐administered. OBE001 is an orally active…”
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Contributions of functional genomics and proteomics to the study of immune responses in the Pacific white leg shrimp Litopenaeus vannamei by Robalino, Javier, Carnegie, Ryan B., O‘Leary, Nuala, Ouvry-Patat, Severine A., de la Vega, Enrique, Prior, Sarah, Gross, Paul S., Browdy, Craig L., Chapman, Robert W., Schey, Kevin L., Warr, Gregory

“…The need for better control of infectious diseases in shrimp aquaculture and the ecological importance of crustacea in marine ecosystems have prompted interest…”
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Characterization of antimicrobial histone sequences and posttranslational modifications by mass spectrometry by Ouvry-Patat, Séverine A., Schey, Kevin L.

“…Histones typically play a role in DNA packaging and transcription regulation. These proteins are heavily modified by acetylation, methylation, phosphorylation…”
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A review of the pharmacokinetics, tolerability and pharmacodynamics of amisulpride in healthy volunteers by Rosenzweig, P., Canal, M., Patat, A., Bergougnan, L., Zieleniuk, I., Bianchetti, G.

“…Amisulpride binds selectively to dopamine D2 and D3 receptors in the limbic system. Low doses of amisulpride preferentially block presynaptic D2/D3‐dopamine…”
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Antimicrobial activity of histones from hemocytes of the Pacific white shrimp by Patat, Séverine A., Carnegie, Ryan B., Kingsbury, Celia, Gross, Paul S., Chapman, Robert, SCHEY, KEVIN L.

“…The role of vertebrate histone proteins or histone derived peptides as innate immune effectors has only recently been appreciated. In this study, high levels…”
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866 ALS-2200, A NOVEL ONCE-DAILY NUCLEOTIDE HCV POLYMERASE INHIBITOR, DEMONSTRATED POTENT ANTIVIRAL ACTIVITY IN TREATMENT-NAÏVE PATIENTS WITH COMPENSATED CIRRHOSIS OR GENOTYPE 2–4 CHRONIC HEPATITIS C by Marcellin, P, Popa, S, Streinu-Cercel, A, Boyer, N, Dospinoiu, D, Patat, A, Ghicavii, N, Garg, V, Kauffman, R.S, Koziel, M, Tong, M.J, Chanda, S, Zhang, Q, Westland, C, Beigelman, L, Blatt, L.M, Fry, J

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Novel Neutrophil-Derived Proteins in Bronchoalveolar Lavage Fluid Indicate an Exaggerated Inflammatory Response in Pediatric Cystic Fibrosis Patients by McMorran, Brendan J, Ouvry Patat, Severine A, Carlin, John B, Grimwood, Keith, Jones, Alun, Armstrong, David S, Galati, John C, Cooper, Peter J, Byrnes, Catherine A, Francis, Paul W, Robertson, Colin F, Hume, David A, Borchers, Christoph H, Wainwright, Claire E, Wainwright, Brandon J

“…Airway inflammation in cystic fibrosis (CF) is exaggerated and characterized by neutrophil-mediated tissue destruction, but its genesis and mechanisms remain…”
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P.1.g.021 Comparison of AChE inhibition/5-HT1A blockade in healthy subjects in a scopolamine model of cognitive impairment by Parks, V, Patat, A, Raje, S, Wesnes, K, Boeijinga, P

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85 ANTIVIRAL ACTIVITY AND SAFETY OF ITMN-191 IN COMBINATION WITH PEGINTERFERON ALFA-2A AND RIBAVIRIN IN PATIENTS WITH CHRONIC HEPATITIS C VIRUS (HCV) by Forestier, N, Larrey, D, Marcellin, P, Benhamou, Y, Guyader, D, Bradford, W, Porter, S, Patat, A, Rouzier, R, Zeuzem, S

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Lack of pharmacokinetic interaction between retigabine and phenobarbitone at steady‐state in healthy subjects by Ferron, Geraldine M., Patat, Alain, Parks, Virginia, Rolan, Paul, Troy, Steven M.

“…Aims  To evaluate potential pharmacokinetic interactions between phenobarbitone and retigabine, a new antiepileptic drug. Methods  Fifteen healthy men received…”
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Psychomotor, cognitive, extrapyramidal, and affective functions of healthy volunteers during treatment with an atypical (amisulpride) and a classic (haloperidol) antipsychotic by RAMAEKERS, J. G, LOUWERENS, J. W, MUNTJEWERFF, N. D, MILIUS, H, DE BIE, A, ROSENZWEIG, P, PATAT, A, O'HANLON, J. F

“…The primary objective of this study was to compare the objective and subjective effects of amisulpride with those of a classic antipsychotic, haloperidol, when…”
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Driving, drug research and the pharmaceutical industry by Patat, A.

“…It is known that psychoactive drugs may produce impairment of attention and skills involved in driving performance and thus may increase the risk of traffic…”
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Safety, pharmacokinetics (PK) and pharmacodynamics (PD) of ascending single doses of desvenlafaxine (DVS-233 SR) in healthy subjects by Parks, V., Patat, A., Behrle, J., Parker, V., Decours, J.

“…Background To assess the safety, tolerability, PK and PD of ascending single oral doses of DVS‐SR in healthy subjects. Methods This was a randomized,…”
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Safety, pharmacokinetics (PK) and pharmacodynamics (PD) of ascending multiple doses of SRA-333 in healthy subjects by Patat, A. A., Parks, V., Raje, S., Plotka, A., Chassard, D.

“…SRA‐333 is a new potent and silent 5HT1a antagonist which increased glutamatergic and cholinergic neurotransmission during cognitive processes. SRA‐333 is…”
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Safety, pharmacokinetics (PK) and pharmacodynamics (PD) of ascending single doses of SRA-333 in healthy subjects by Patat, A. A., Parks, V., Raje, S., Plotka, A., Chassard, D.

“…SRA‐333 is a new potent and silent 5HT1a antagonist which increased glutamatergic and cholinergic neurotransmission during cognitive processes. SRA‐333 is…”
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Pharmacokinetic (PK) interaction study of sirolimus (SRL) and cyclosporine (CSA) by Patat, A., Zimmerman, J. J., Parks, V., Richards, J.

“…SRL (Rapamune®) is an effective immunosuppressant currently marketed worldwide for the prophylaxis of renal allograft rejection. The interaction between SRL 5…”
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