Search Results - "Patapoff, T W"

Surface expression, polarization, and functional significance of CD73 in human intestinal epithelia by Strohmeier, G R, Lencer, W I, Patapoff, T W, Thompson, L F, Carlson, S L, Moe, S J, Carnes, D K, Mrsny, R J, Madara, J L

“…During active intestinal inflammation polymorphonuclear leukocytes (PMN) transmigrate into the lumen and release 5'-AMP (J. Clin. Invest. 1993. 91:2320-2325)…”
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Lyophilization of protein formulations in vials: investigation of the relationship between resistance to vapor flow during primary drying and small-scale product collapse by Overcashier, D E, Patapoff, T W, Hsu, C C

“…During the lyophilization process, formulations containing protein, bulking agent, or lyoprotectant form a dry product layer that can affect the transport of…”
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Laser Raman Microscopy of Chromosomes in Living Eukaryotic Cells: DNA Polymorphism In Vivo by Peticolas, W. L., Patapoff, T. W., Thomas, G. A., Postlewait, J., Powell, J. W.

“…In order to answer the question of what the structure of DNA is in the nucleus of a living cell where its long length must be subjected to repeated folds in…”
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Effects of reducing sugars on the chemical stability of human relaxin in the lyophilized state by Li, S, Patapoff, T W, Overcashier, D, Hsu, C, Nguyen, T H, Borchardt, R T

“…Sugars and polyols have been used routinely with lyophilized proteins and peptides as bulking agents, cryoprotectants, and lyoprotectants. However, reducing…”
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The effect of benzyl alcohol on recombinant human interferon-γ by LAM, X. M, PATAPOFF, T. W, NGUYEN, T. H

“…The goal of this study was to investigate the conformational change and aggregation of recombinant human interferon-gamma (rhIFN-gamma) as a result of…”
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Intranasal bioavailability of insulin powder formulations: effect of permeation enhancer-to-protein ratio by Lee, W A, Narog, B A, Patapoff, T W, Wang, Y J

“…The intranasal administration of powder formulations containing insulin and the permeation enhancer sodium tauro-24,25-dihydrofusidate (STDHF) were…”
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Activated eosinophils evoke chloride secretion in model intestinal epithelia primarily via regulated release of 5'-AMP by Resnick, MB, Colgan, SP, Patapoff, TW, Mrsny, RJ, Awtrey, CS, Delp-Archer, C, Weller, PF, Madara, JL

“…Eosinophils may be prominent in intestinal diseases including allergic gastroenteritis, inflammatory bowel disease, enteritis associated with hypereosinophilic…”
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The application of size exclusion chromatography and computer simulation to study the thermodynamic and kinetic parameters for short-lived dissociable protein aggregates by Patapoff, T W, Mrsny, R J, Lee, W A

“…We describe a method to study the monomer-dimer equilibrium of human growth hormone (hGH) making use of a very short size exclusion high-performance liquid…”
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Kinetics and Thermodynamics of Dimer Formation and Dissociation for a Recombinant Humanized Monoclonal Antibody to Vascular Endothelial Growth Factor by Moore, Jamie M. R, Patapoff, Thomas W, Cromwell, Mary E. M

“…The recombinant humanized antibody (rhuMAb) VEGF has a high affinity for vascular endothelial growth factor and is currently being evaluated in clinical trials…”
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Compaction assay: a rapid and simple in vitro method to assess the responsiveness of a biopolymer matrix to enzymatic modification by Daugherty, Ann L., Patapoff, Thomas W., Clark, Ross C., Sinicropi, Dominick V., Mrsny, Randall J.

“…A rapid and simple in vitro method is described which measures the extent of unrecoiled solids compression when a complex biopolymer is subjected to a…”
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5'-adenosine monophosphate is the neutrophil-derived paracrine factor that elicits chloride secretion from T84 intestinal epithelial cell monolayers by Madara, J L, Patapoff, T W, Gillece-Castro, B, Colgan, S P, Parkos, C A, Delp, C, Mrsny, R J

“…Neutrophil transmigration across intestinal epithelia is thought to contribute to epithelial dysfunction and characterizes many inflammatory intestinal…”
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Raman spectra of the model B-DNA oligomer d(CGCGAATTCGCG)2 and of the DNA in living salmon sperm show that both have very similar B-type conformations by Kubasek, William L, Wang, Yang, Thomas, Gerald A, Patapoff, Thomas W, Schoenwaelder, Karl Heinz, Van der Sande, Johan H, Peticolas, Warner L

“…Raman spectra were obtained from aqueous solutions of the deoxyoligonucleotide d(CGCGAATTCGCG)2 (I), which has been suggested as a model for B-type DNA…”
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Inhibitory effect of sugars and polyols on the metal-catalyzed oxidation of human relaxin by Li, S, Patapoff, T W, Nguyen, T H, Borchardt, R T

“…Previously, our laboratory (Li, S.; et al. Biochemistry 1995, 34, 5762-5772) showed that the oxidation of recombinant human relaxin (Rix) could be induced by…”
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Polarized Raman scattering from oriented single microcrystals of d(A5T5)2 and d(pTpT) by Patapoff, T W, Thomas, G A, Wang, Y, Peticolas, W L

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Single step method for the accurate concentration determination of polysorbate 80 by Tani, Travis H., Moore, Jamie M., Patapoff, Thomas W.

“…A simple high-performance liquid chromatography (HPLC) method is described that has the potential of determining the concentration of numerous classes of…”
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Multiple equilibria binding treatment of lipid and detergent interactions with membrane proteins. Application to cytochrome c oxidase solubilized in cholate by Volwerk, Johannes J, Mrsny, Randall J, Patapoff, Thomas W, Jost, Patricia C, Griffith, O. Hayes

“…A modified multiple binding equilibria treatment is presented that allows determination of thermodynamic parameters of the interaction of phospholipids with…”
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A Low-Volume, Short-Path Length Dynamic Light Scattering Sample Cell for Highly Turbid Suspensions by Patapoff, Thomas W., Tani, Travis H., Cromwell, Mary E.M.

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Addition of a bacterial alginate lyase to purulent CF sputum in vitro can result in the disruption of alginate and modification of sputum viscoelasticity by Mrsny, R J, Lazazzera, B A, Daugherty, A L, Schiller, N L, Patapoff, T W

“…Alginate is a large molecular weight exopolysaccharide present in the purulent airway secretions of cystic fibrosis (CF) patients. This polymer, produced by…”
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A Spectral Method for Color Quantitation of a Protein Drug Solution by Swartz, Trevor E, Yin, Jian, Patapoff, Thomas W, Horst, Travis, Skieresz, Susan M, Leggett, Gordon, Morgan, Charles J, Rahimi, Kimia, Marhoul, Joseph, Kabakoff, Bruce

“…Color is an important quality attribute for biotherapeutics. In the biotechnology industry, a visual method is most commonly utilized for color…”
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Validation of a Spectral Method for Quantitative Measurement of Color in Protein Drug Solutions by Yin, Jian, Swartz, Trevor E, Zhang, Jian, Patapoff, Thomas W, Chen, Bartolo, Marhoul, Joseph, Shih, Norman, Kabakoff, Bruce, Rahimi, Kimia

“…A quantitative spectral method has been developed to precisely measure the color of protein solutions. In this method, a spectrophotometer is utilized for…”
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