Search Results - "Patani, R"

Remyelination can be extensive in multiple sclerosis despite a long disease course by Patani, R., Balaratnam, M., Vora, A., Reynolds, R.

“…Experimental studies using models of multiple sclerosis (MS) indicate that rapid and extensive remyelination of inflammatory demyelinated lesions is not only…”
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Human embryonic stem cell derived astrocytes mediate non-cell-autonomous neuroprotection through endogenous and drug-induced mechanisms by Gupta, K, Patani, R, Baxter, P, Serio, A, Story, D, Tsujita, T, Hayes, J D, Pedersen, R A, Hardingham, G E, Chandran, S

“…The glial environment is an important determinant of neuronal health in experimental models of neurodegeneration. Specifically, astrocytes have been shown,…”
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Lymphomatosis cerebri: a treatable cause of rapidly progressive dementia by Samani, Amit, Davagnanam, Indran, Cockerell, Oliver Charles, Ramsay, Alan, Patani, Rickie, Chataway, Jeremy

“…Cerebrospinal fluid (CSF) examination showed a protein level of 0.74 g/L with a glucose of 3.2 mmol/L (serum 5.5 mmol/L), <1 white blood cell per millilitre…”
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Abnormally phosphorylated tau is associated with neuronal and axonal loss in experimental autoimmune encephalomyelitis and multiple sclerosis by Anderson, J. M., Hampton, D. W., Patani, R., Pryce, G., Crowther, R. A., Reynolds, R., Franklin, R. J. M., Giovannoni, G., Compston, D. A. S., Baker, D., Spillantini, M. G., Chandran, S.

“…The pathological correlate of clinical disability and progression in multiple sclerosis is neuronal and axonal loss; however, the underlying mechanisms are…”
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Retinoid-independent motor neurogenesis from human embryonic stem cells reveals a medial columnar ground state by Allen, N. D, Chandran, S, Patani, R, Hollins, A. J, Wishart, T. M, Puddifoot, C. A, Álvarez, S, de Lera, A. R, Wyllie, D. J. A, Compston, D. A. S, Pedersen, R. A, Gillingwater, T. H, Hardingham, G. E

“…A major challenge in neurobiology is to understand mechanisms underlying human neuronal diversification. Motor neurons (MNs) represent a diverse collection of…”
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Stem cells as a resource for regenerative neurology by Connick, P, Patani, R, Chandran, S

“…Public and media interest in the potential applications of stem cells in regenerative neurology has led to growing hope and expectation. This interest is…”
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Mapping loss of heterozygosity in normal human breast cells from BRCA1 2 carriers by Clarke, C L, Sandle, J, Jones, A A, Sofronis, A, Patani, N R, Lakhani, S R

“…We have studied loss of heterozygosity at the BRCA1 and BRCA2 loci in 992 normal cell clones derived from topographically defined areas of normal tissue in…”
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Cellular infiltration in traumatic brain injury by Alam, Aftab, Thelin, Eric P, Tajsic, Tamara, Khan, Danyal Z, Khellaf, Abdelhakim, Patani, Rickie, Helmy, Adel

“…Traumatic brain injury leads to cellular damage which in turn results in the rapid release of damage-associated molecular patterns (DAMPs) that prompt resident…”
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Elevated protein tyrosine phosphatase activity provokes Eph/ephrin-facilitated adhesion of pre-B leukemia cells by Wimmer-Kleikamp, Sabine H., Nievergall, Eva, Gegenbauer, Kristina, Adikari, Samantha, Mansour, Mariam, Yeadon, Trina, Boyd, Andrew W., Patani, Neill R., Lackmann, Martin

“…Signaling by Eph receptors and cell-surface ephrin ligands modulates adhesive cell properties and thereby coordinates cell movement and positioning in normal…”
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MND01 - Establishing motor neuron and astrocytic cultures to study spinal and bulbar muscular atrophy by Devine, H.E., Malik, B., Mitchell, J., Greensmith, L., Patani, R.

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Establishing motor neuron and astrocytic cultures to study spinal and bulbar muscular atrophy by Devine, H.E., Malik, B., Mitchell, J., Greensmith, L., Patani, R.

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Predictors of axillary lymph node metastasis in breast cancer: A systematic review by Patani, N.R, Dwek, M.V, Douek, M

“…Abstract Aims To review the established and emerging techniques in axillary lymph node prediction and explore their potential impact on clinical practice. To…”
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Astrocytes display cell autonomous and diverse early reactive states in familial amyotrophic lateral sclerosis by Taha, Doaa M, Clarke, Benjamin E, Hall, Claire E, Tyzack, Giulia E, Ziff, Oliver J, Greensmith, Linda, Kalmar, Bernadett, Ahmed, Mhoriam, Alam, Aftab, Thelin, Eric P, Garcia, Nuria Marco, Helmy, Adel, Sibley, Christopher R, Patani, Rickie

“…Amyotrophic lateral sclerosis is a rapidly progressive and fatal disease. Although astrocytes are increasingly recognized contributors to the underlying…”
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Modeling the Inflammatory Response of Traumatic Brain Injury Using Human Induced Pluripotent Stem Cell Derived Microglia by Alam, Aftab, Singh, Tanya, Kayhanian, Saeed, Tjerkaski, Jonathan, Garcia, Núria Marcó, Carpenter, Keri L H, Patani, Rickie, Lindblad, Caroline, Thelin, Eric P, Syed, Yasir Ahmed, Helmy, Adel

“…The neuroinflammatory response after traumatic brain injury (TBI) is implicated as a key mediator of secondary injury in both the acute and chronic periods…”
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MIR-NATs repress MAPT translation and aid proteostasis in neurodegeneration by Simone, Roberto, Javad, Faiza, Emmett, Warren, Wilkins, Oscar G., Almeida, Filipa Lourenço, Barahona-Torres, Natalia, Zareba-Paslawska, Justyna, Ehteramyan, Mazdak, Zuccotti, Paola, Modelska, Angelika, Siva, Kavitha, Virdi, Gurvir S., Mitchell, Jamie S., Harley, Jasmine, Kay, Victoria A., Hondhamuni, Geshanthi, Trabzuni, Daniah, Ryten, Mina, Wray, Selina, Preza, Elisavet, Kia, Demis A., Pittman, Alan, Ferrari, Raffaele, Manzoni, Claudia, Lees, Andrew, Hardy, John A., Denti, Michela A., Quattrone, Alessandro, Patani, Rickie, Svenningsson, Per, Warner, Thomas T., Plagnol, Vincent, Ule, Jernej, de Silva, Rohan

“…The human genome expresses thousands of natural antisense transcripts (NAT) that can regulate epigenetic state, transcription, RNA stability or translation of…”
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Elucidating Pro-Inflammatory Cytokine Responses after Traumatic Brain Injury in a Human Stem Cell Model by Thelin, Eric Peter, Hall, Claire E, Gupta, Kunal, Carpenter, Keri L H, Chandran, Siddharthan, Hutchinson, Peter J, Patani, Rickie, Helmy, Adel

“…Cytokine mediated inflammation likely plays an important role in secondary pathology after traumatic brain injury (TBI). The aim of this study was to elucidate…”
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Human stem cell-derived astrocytes exhibit region-specific heterogeneity in their secretory profiles by Clarke, Benjamin E, Taha, Doaa M, Ziff, Oliver J, Alam, Aftab, Thelin, Eric P, García, Núria Marcó, Helmy, Adel, Patani, Rickie

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TP1-4 In vitro induced cytokine response of astrocytes modelling conditions in human traumatic brain injury by Thelin, EP, Hall, CE, Frostell, A, Tajsic, T, Carpenter, KLH, Hutchinson, PJA, Patani, R, Helmy, A

“…ObjectivesThe objective of this study was to investigate how in vitro astrocyte cultures respond to cytokine pro- and anti-inflammatory cytokine…”
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Delineating Astrocytic Cytokine Responses in a Human Stem Cell Model of Neural Trauma by Thelin, Eric Peter, Hall, Claire E, Tyzack, Giulia E, Frostell, Arvid, Giorgi-Coll, Susan, Alam, Aftab, Carpenter, Keri L H, Mitchell, Jamie, Tajsic, Tamara, Hutchinson, Peter J, Patani, Rickie, Helmy, Adel

“…Neuroinflammation has been shown to mediate the pathophysiological response following traumatic brain injury (TBI). Accumulating evidence implicates astrocytes…”
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Nipped in the Budd’: hepatic venous outflow obstruction in evolution by Karageorgiou, Haris, Mookerjee, Rajeshwar P, Patani, Neill R, Pachiadakis, Ioannis, Usiskin, Sasha I, Gillams, Alice, Lees, William R, Williams, Roger, Douek, Michael, Jalan, Rajiv

“…Hepatic venous thrombosis (Budd-Chiari) in evolution is a rare phenomenon and carries a high morbidity and mortality. We describe the case of a 39-year-old…”
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