The association of congenital hypothyroidism and congenital gastrointestinal anomalies in Down's syndrome infants

To study the prevalence of congenital hypothyroidism in infants with Down's syndrome and to verify whether there is an association with other congenital defects. This is a prospective study of 112 Down patients, less than 1 year of age, who attended Songklanagarind Hospital from January 1991 to...

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Bibliographic Details
Published in:	Journal of pediatric endocrinology & metabolism : JPEM Vol. 11; no. 2; p. 241
Main Authors:	Jaruratanasirikul, S, Patarakijvanich, N, Patanapisarnsak, C
Format:	Journal Article
Language:	English
Published:	Germany 01-03-1998
Subjects:	Congenital Hypothyroidism Digestive System Abnormalities Down Syndrome - complications Down Syndrome - pathology Female Humans Hypothyroidism - epidemiology Infant Infant, Newborn Male Prevalence Prospective Studies Thailand Thyroid Function Tests Thailand
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Summary:	To study the prevalence of congenital hypothyroidism in infants with Down's syndrome and to verify whether there is an association with other congenital defects. This is a prospective study of 112 Down patients, less than 1 year of age, who attended Songklanagarind Hospital from January 1991 to December 1996. Free T4 and TSH determinations were performed in all Down infants. Information on karyotype, sex, maternal age and other congenital anomalies was collected. Congenital hypothyroidism was detected in 17 patients (15.2%); 3 overt congenital hypothyroidism; 6 persistent compensated hypothyroidism; and 8 transient compensated hypothyroidism. Nine of the 20 patients (45%) with congenital gastrointestinal anomalies had congenital hypothyroidism, while 8 out of 92 patients (8.7%) without congenital gastrointestinal anomalies had congenital hypothyroidism. The odds ratio was 8.59 (95% confidence interval 2.4-31.6; p = 0.0001). Congenital hypothyroidism has a relatively high prevalence rate in Down infants and tends to occur in Down patients with gastrointestinal anomalies.
ISSN:	0334-018X
DOI:	10.1515/JPEM.1998.11.2.241