Fluorescence‐based bowel anastomosis perfusion evaluation: results from the IHU‐IRCAD‐EAES EURO‐FIGS registry

Background Anastomotic leakage (AL) is one of the dreaded complications following surgery in the digestive tract. Near-infrared fluorescence (NIRF) imaging is a means to intraoperatively visualize anastomotic perfusion, facilitating fluorescence image-guided surgery (FIGS) with the purpose to reduce...

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Published in:	Surgical endoscopy Vol. 35; no. 12; pp. 7142 - 7153
Main Authors:	Spota, Andrea, Al-Taher, Mahdi, Felli, Eric, Morales Conde, Salvador, Dal Dosso, Ivano, Moretto, Gianluigi, Spinoglio, Giuseppe, Baiocchi, Gianluca, Vilallonga, Ramon, Impellizzeri, Harmony, Martin-Martin, Gonzalo P., Casali, Lorenzo, Franzini, Christian, Silvestri, Marta, de Manzini, Nicolò, Castagnola, Maurizio, Filauro, Marco, Cosola, Davide, Copaescu, Catalin, Garbarino, Giovanni Maria, Pesce, Antonio, Calabrò, Marcello, de Nardi, Paola, Anania, Gabriele, Carus, Thomas, Boni, Luigi, Patané, Alessandro, Santi, Caterina, Saadi, Alend, Rollo, Alessio, Chautems, Roland, Noguera, José, Grosek, Jan, D’Ambrosio, Giancarlo, Ferreira, Carlos Marques, Norcic, Gregor, Navarra, Giuseppe, Riva, Pietro, Quaresima, Silvia, Paganini, Alessandro, Rosso, Nunzio, De Paolis, Paolo, Balla, Andrea, Sauvain, Marc Olivier, Gialamas, Eleftherios, Bianchi, Giorgio, La Greca, Gaetano, Castoro, Carlo, Picchetto, Andrea, Franchello, Alessandro, Tartamella, Luciano, Juvan, Robert, Ioannidis, Orestis, Kosir, Jurij Ales, Bertani, Emilio, Stassen, Laurents, Marescaux, Jacques, Diana, Michele
Format:	Journal Article
Language:	English
Published:	New York Springer US 01-12-2021 Springer Nature B.V Springer Verlag (Germany)
Subjects:	Abdominal Surgery Anastomosis, Surgical - adverse effects Anastomotic Leak - epidemiology Anastomotic Leak - etiology Cancer Consent Data collection Endoscopy Engineering Sciences Esophagus Gastroenterology Gastrointestinal surgery Gynecology Hepatology Humans Indocyanine Green Medical research Medicine Medicine & Public Health Optics Patients Perfusion Photonic Proctology Registries Surgeons Surgery Surgery, Computer-Assisted Surgical outcomes Image-guided surgery Registry Near-infrared fluorescence imaging Fluorescence-guided surgery
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Summary:	Background Anastomotic leakage (AL) is one of the dreaded complications following surgery in the digestive tract. Near-infrared fluorescence (NIRF) imaging is a means to intraoperatively visualize anastomotic perfusion, facilitating fluorescence image-guided surgery (FIGS) with the purpose to reduce the incidence of AL. The aim of this study was to analyze the current practices and results of NIRF imaging of the anastomosis in digestive tract surgery through the EURO-FIGS registry. Methods Analysis of data prospectively collected by the registry members provided patient and procedural data along with the ICG dose, timing, and consequences of NIRF imaging. Among the included upper-GI, colorectal, and bariatric surgeries, subgroup analysis was performed to identify risk factors associated with complications. Results A total of 1240 patients were included in the study. The included patients, 74.8% of whom were operated on for cancer, originated from 8 European countries and 30 hospitals. A total of 54 surgeons performed the procedures. In 83.8% of cases, a pre-anastomotic ICG dose was administered, and in 60.1% of cases, a post-anastomotic ICG dose was administered. A significant difference ( p < 0.001) was found in the ICG dose given in the four pathology groups registered (range: 0.013–0.89 mg/kg) and a significant ( p < 0.001) negative correlation was found between the ICG dose and BMI. In 27.3% of the procedures, the choice of the anastomotic level was guided by means of NIRF imaging which means that in these cases NIRF imaging changed the level of anastomosis which was first decided based on visual findings in conventional white light imaging. In 98.7% of the procedures, the use of ICG partly or strongly provided a sense of confidence about the anastomosis. A total of 133 complications occurred, without any statistical significance in the incidence of complications in the anastomoses, whether they were ICG-guided or not. Conclusion The EURO-FIGS registry provides an insight into the current clinical practice across Europe with respect to NIRF imaging of anastomotic perfusion during digestive tract surgery.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0930-2794 1432-2218
DOI:	10.1007/s00464-020-08234-8