Search Results - "Paszek, Pawel"

Application of Sensitivity Analysis to Discover Potential Molecular Drug Targets by Kardynska, Malgorzata, Smieja, Jaroslaw, Paszek, Pawel, Puszynski, Krzysztof

“…Mathematical modeling of signaling pathways and regulatory networks has been supporting experimental research for some time now. Sensitivity analysis, aimed at…”
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Fenamate NSAIDs inhibit the NLRP3 inflammasome and protect against Alzheimer’s disease in rodent models by Daniels, Michael J. D., Rivers-Auty, Jack, Schilling, Tom, Spencer, Nicholas G., Watremez, William, Fasolino, Victoria, Booth, Sophie J., White, Claire S., Baldwin, Alex G., Freeman, Sally, Wong, Raymond, Latta, Clare, Yu, Shi, Jackson, Joshua, Fischer, Nicolas, Koziel, Violette, Pillot, Thierry, Bagnall, James, Allan, Stuart M., Paszek, Pawel, Galea, James, Harte, Michael K., Eder, Claudia, Lawrence, Catherine B., Brough, David

“…Non-steroidal anti-inflammatory drugs (NSAIDs) inhibit cyclooxygenase-1 (COX-1) and COX-2 enzymes. The NLRP3 inflammasome is a multi-protein complex…”
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Integration of Kinase and Calcium Signaling at the Level of Chromatin Underlies Inducible Gene Activation in T Cells by Brignall, Ruth, Cauchy, Pierre, Bevington, Sarah L, Gorman, Bethany, Pisco, Angela O, Bagnall, James, Boddington, Christopher, Rowe, William, England, Hazel, Rich, Kevin, Schmidt, Lorraine, Dyer, Nigel P, Travis, Mark A, Ott, Sascha, Jackson, Dean A, Cockerill, Peter N, Paszek, Pawel

“…TCR signaling pathways cooperate to activate the inducible transcription factors NF-κB, NFAT, and AP-1. In this study, using the calcium ionophore ionomycin…”
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Population robustness arising from cellular heterogeneity by Paszek, Pawel, Ryan, Sheila, Ashall, Louise, Sillitoe, Kate, Harper, Claire V., Spiller, David G., Rand, David A., White, Michael R. H., Friedman, Avner

“…Heterogeneity between individual cells is a common feature of dynamic cellular processes, including signaling, transcription, and cell fate; yet the overall…”
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Live-cell imaging reveals single-cell and population-level infection strategies of Listeria monocytogenes in macrophages by Moran, Josephine, Feltham, Liam, Bagnall, James, Goldrick, Marie, Lord, Elizabeth, Nettleton, Catherine, Spiller, David G., Roberts, Ian, Paszek, Pawel

“…Pathogens have developed intricate strategies to overcome the host’s innate immune responses. In this paper we use live-cell microscopy with a single bacterium…”
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Signal transduction controls heterogeneous NF-κB dynamics and target gene expression through cytokine-specific refractory states by Adamson, Antony, Boddington, Christopher, Downton, Polly, Rowe, William, Bagnall, James, Lam, Connie, Maya-Mendoza, Apolinar, Schmidt, Lorraine, Harper, Claire V., Spiller, David G., Rand, David A., Jackson, Dean A., White, Michael R. H., Paszek, Pawel

“…Cells respond dynamically to pulsatile cytokine stimulation. Here we report that single, or well-spaced pulses of TNFα (>100 min apart) give a high probability…”
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Quantitative analysis of competitive cytokine signaling predicts tissue thresholds for the propagation of macrophage activation by Bagnall, James, Boddington, Christopher, England, Hazel, Brignall, Ruth, Downton, Polly, Alsoufi, Zainab, Boyd, James, Rowe, William, Bennett, Alexander, Walker, Catherine, Adamson, Antony, Patel, Nisha M X, O'Cualain, Ronan, Schmidt, Lorraine, Spiller, David G, Jackson, Dean A, Müller, Werner, Muldoon, Mark, White, Michael R H, Paszek, Pawel

“…Toll-like receptor (TLR) signaling regulates macrophage activation and effector cytokine propagation in the constrained environment of a tissue. In macrophage…”
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Dynamic NF-κB and E2F interactions control the priority and timing of inflammatory signalling and cell proliferation by Ankers, John M, Awais, Raheela, Jones, Nicholas A, Boyd, James, Ryan, Sheila, Adamson, Antony D, Harper, Claire V, Bridge, Lloyd, Spiller, David G, Jackson, Dean A, Paszek, Pawel, Sée, Violaine, White, Michael Rh

“…Dynamic cellular systems reprogram gene expression to ensure appropriate cellular fate responses to specific extracellular cues. Here we demonstrate that the…”
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Variability of the innate immune response is globally constrained by transcriptional bursting by Alachkar, Nissrin, Norton, Dale, Wolkensdorfer, Zsofia, Muldoon, Mark, Paszek, Pawel

“…Transcription of almost all mammalian genes occurs in stochastic bursts, however the fundamental control mechanisms that allow appropriate single-cell…”
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Post-transcriptional regulatory feedback encodes JAK-STAT signal memory of interferon stimulation by Kalliara, Eirini, Kardynska, Malgorzata, Bagnall, James, Spiller, David G., Müller, Werner, Ruckerl, Dominik, Śmieja, Jarosław, Biswas, Subhra K., Paszek, Pawel

“…Immune cells fine tune their responses to infection and inflammatory cues. Here, using live-cell confocal microscopy and mathematical modelling, we investigate…”
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Stochasticity in the miR-9/Hes1 oscillatory network can account for clonal heterogeneity in the timing of differentiation by Phillips, Nick E, Manning, Cerys S, Pettini, Tom, Biga, Veronica, Marinopoulou, Elli, Stanley, Peter, Boyd, James, Bagnall, James, Paszek, Pawel, Spiller, David G, White, Michael Rh, Goodfellow, Marc, Galla, Tobias, Rattray, Magnus, Papalopulu, Nancy

“…Recent studies suggest that cells make stochastic choices with respect to differentiation or division. However, the molecular mechanism underlying such…”
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Bacterial aggregation facilitates internalin-mediated invasion of Listeria monocytogenes by Feltham, Liam, Moran, Josephine, Goldrick, Marie, Lord, Elizabeth, Spiller, David G, Cavet, Jennifer S, Muldoon, Mark, Roberts, Ian S, Paszek, Pawel

“…Dissemination of food-borne in the host relies on internalin-mediated invasion, but the underlying invasion strategies remain elusive. Here we use live-cell…”
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Macrophage-Specific NF-κB Activation Dynamics Can Segregate Inflammatory Bowel Disease Patients by Papoutsopoulou, Stamatia, Burkitt, Michael D, Bergey, François, England, Hazel, Hough, Rachael, Schmidt, Lorraine, Spiller, David G, White, Michael H R, Paszek, Pawel, Jackson, Dean A, Martins Dos Santos, Vitor A P, Sellge, Gernot, Pritchard, D Mark, Campbell, Barry J, Müller, Werner, Probert, Chris S

“…The heterogeneous nature of inflammatory bowel disease (IBD) presents challenges, particularly when choosing therapy. Activation of the NF-κB transcription…”
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Quantitative analysis reveals crosstalk mechanisms of heat shock-induced attenuation of NF-κB signaling at the single cell level by Kardyńska, Małgorzata, Paszek, Anna, Śmieja, Jarosław, Spiller, David, Widłak, Wiesława, White, Michael R H, Paszek, Pawel, Kimmel, Marek

“…Elevated temperature induces the heat shock (HS) response, which modulates cell proliferation, apoptosis, the immune and inflammatory responses. However,…”
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Heat shock response regulates stimulus-specificity and sensitivity of the pro-inflammatory NF-κB signalling by Paszek, Anna, Kardyńska, Małgorzata, Bagnall, James, Śmieja, Jarosław, Spiller, David G, Widłak, Piotr, Kimmel, Marek, Widlak, Wieslawa, Paszek, Pawel

“…Ability to adapt to temperature changes trough the Heat Shock Response (HSR) pathways is one of the most fundamental and clinically relevant cellular response…”
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Single TNFα trimers mediating NF-κ B activation: stochastic robustness of NF-κ B signaling by Lipniacki, Tomasz, Puszynski, Krzysztof, Paszek, Pawel, Brasier, Allan R, Kimmel, Marek

“…Background The NF- Kappa B regulatory network controls innate immune response by transducing variety of pathogen-derived and cytokine stimuli into well defined…”
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Overexpression of IκB⍺ modulates NF-κB activation of inflammatory target gene expression by Downton, Polly, Bagnall, James S, England, Hazel, Spiller, David G, Humphreys, Neil E, Jackson, Dean A, Paszek, Pawel, White, Michael R H, Adamson, Antony D

“…Cells respond to inflammatory stimuli such as cytokines by activation of the nuclear factor-κB (NF-κB) signalling pathway, resulting in oscillatory…”
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Stochastic Regulation in Early Immune Response by Lipniacki, Tomasz, Paszek, Pawel, Brasier, Allan R., Luxon, Bruce A., Kimmel, Marek

“…Living cells may be considered noisy or stochastic biochemical reactors. In eukaryotic cells, in which the number of protein or mRNA molecules is relatively…”
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Interactions among oscillatory pathways in NF-kappa B signaling by Wang, Yunjiao, Paszek, Pawel, Horton, Caroline A, Kell, Douglas B, White, Michael Rh, Broomhead, David S, Muldoon, Mark R

“…Sustained stimulation with tumour necrosis factor alpha (TNF-alpha) induces substantial oscillations--observed at both the single cell and population…”
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How the Number of Alleles Influences Gene Expression by Hat, Beata, Paszek, Pawel, Kimmel, Marek, Piechor, Kazimierz, Lipniacki, Tomasz

“…The higher organisms, eukaryotes, are diploid and most of their genes have two homological copies (alleles). However, the number of alleles in a cell is not…”
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