Search Results - "Paszek, Miles"

Crypt Organoid Culture as an in Vitro Model in Drug Metabolism and Cytotoxicity Studies by Lu, Wenqi, Rettenmeier, Eva, Paszek, Miles, Yueh, Mei-Fei, Tukey, Robert H, Trottier, Jocelyn, Barbier, Olivier, Chen, Shujuan

“…The gastrointestinal tract is enriched with xenobiotic processing proteins that play important roles in xenobiotic bioactivation, metabolism, and…”
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NCoR1 Protects Mice From Dextran Sodium Sulfate–Induced Colitis by Guarding Colonic Crypt Cells From Luminal Insult by Mennillo, Elvira, Yang, Xiaojing, Paszek, Miles, Auwerx, Johan, Benner, Christopher, Chen, Shujuan

“…Colonic stem cells are essential for producing the mucosal lining, which in turn protects stem cells from insult by luminal factors. Discovery of genetic and…”
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NRF2-Independent Regulation of Intestinal Constitutive Androstane Receptor by the Pro-Oxidants Cadmium and Isothiocyanate in hUGT1 Mice by Paszek, Miles, Tukey, Robert H

“…Environmental toxicants such as heavy metals from contaminated water or soil and isothiocyanates (ITC) from dietary sources act as pro-oxidants by directly…”
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Investigating the DNA binding and transactivation activity of rdyCRX as a molecular basis for retinal dysplasia in Felis catus (943.1) by Paszek, Miles, Lipsett, Koren

“…In a pedigree developed from affected Abyssinian cats, an early onset rod‐cone dysplasia (Rdy) was identified and demonstrates an autosomal dominant…”
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Isothiocyanates Activate the Constitutive Androstane Receptor in an Oxidative Stress Dependent Manner in hUGT1 Mice by Paszek, Miles, Yoda, Emiko, Chen, Shujuan, Tukey, Robert H.

“…Our laboratory has previously developed a humanized UDP‐glucuronosyltransferase 1 (hUGT1) mouse model, creating an in vivo model to examine UGT1A metabolism…”
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2-OR: Exosomes from Adipose Tissue Macrophages Can Mediate Insulin-Sensitizing Effects of Rosiglitazone by ROHM, THERESA V., REIS, FELIPE C.G., ISAAC, ROI, PASZEK, MILES, BANDYOPADHYAY, GAUTAM, OLEFSKY, JERROLD M.

“…Background: The beneficial metabolic effects of the PPARγ agonist rosiglitazone (Rosi) are associated with anti-inflammatory changes in adipose tissue…”
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Oral arsenic administration to humanized UDP-glucuronosyltransferase 1 neonatal mice induces UGT1A1 through a dependence on Nrf2 and PXR by Yang, Xiaojing, Weber, André A., Mennillo, Elvira, Paszek, Miles, Wong, Samantha, Le, Sabrina, Teo, Jia Ying Ashley, Chang, Max, Benner, Christopher W., Tukey, Robert H., Chen, Shujuan

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Isothiocyanates induce UGT1A1 in humanized UGT1 mice in a CAR dependent fashion that is highly dependent upon oxidative stress by Yoda, Emiko, Paszek, Miles, Konopnicki, Camille, Fujiwara, Ryoichi, Chen, Shujuan, Tukey, Robert H.

“…Isothiocyanates, such as phenethyl isothiocyanate (PEITC), are formed following the consumption of cruciferous vegetables and generate reactive oxygen species…”
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Oral arsenic administration to humanizedUDP-glucuronosyltransferase1 neonatal mice induces UGT1A1 through a dependence on Nrf2 and PXR by Yang, Xiaojing, Weber, André A., Mennillo, Elvira, Paszek, Miles, Wong, Samantha, Le, Sabrina, Teo, Jia Ying Ashley, Chang, Max, Benner, Christopher W., Tukey, Robert H., Chen, Shujuan

“…Inorganic arsenic (iAs) is an environmental toxicant that can lead to severe health consequences, which can be exacerbated if exposure occurs early in…”
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NRF2-Independent Regulation of Drug Metabolism by CAR and Prooxidants by Paszek, Miles

“…Exposure to toxicants that create oxidative stress, such as isothiocyanates (ITCs) and heavy metals, initiate inductions of antioxidant response genes and…”
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Intestinal NCoR1, a regulator of epithelial cell maturation, controls neonatal hyperbilirubinemia by Chen, Shujuan, Lu, Wenqi, Yueh, Mei-Fei, Rettenmeier, Eva, Liu, Miao, Paszek, Miles, Auwerx, Johan, Yu, Ruth T., Evans, Ronald M., Wang, Kepeng, Karin, Michael, Tukey, Robert H.

“…Severe neonatal hyperbilirubinemia (SNH) and the onset of bilirubin encephalopathy and kernicterus result in part from delayed expression of…”
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NCoR1 Protects Mice From Dextran Sodium Sulfate–Induced Colitis by Guarding Colonic Crypt Cells From Luminal InsultSummary by Elvira Mennillo, Xiaojing Yang, Miles Paszek, Johan Auwerx, Christopher Benner, Shujuan Chen

“…Background & Aims: Colonic stem cells are essential for producing the mucosal lining, which in turn protects stem cells from insult by luminal factors…”
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