Search Results - "Pasunooti, Kalyan"

Simultaneous Targeting of NPC1 and VDAC1 by Itraconazole Leads to Synergistic Inhibition of mTOR Signaling and Angiogenesis by Head, Sarah A, Shi, Wei Q, Yang, Eun Ju, Nacev, Benjamin A, Hong, Sam Y, Pasunooti, Kalyan K, Li, Ruo-Jing, Shim, Joong Sup, Liu, Jun O

“…The antifungal drug itraconazole was recently found to exhibit potent antiangiogenic activity and has since been repurposed as an investigational anticancer…”
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Antifungal drug itraconazole targets VDAC1 to modulate the AMPK/mTOR signaling axis in endothelial cells by Head, Sarah A., Shi, Wei, Zhao, Liang, Gorshkov, Kirill, Pasunooti, Kalyan, Chen, Yue, Deng, Zhiyou, Li, Ruo-jing, Shim, Joong Sup, Tan, Wenzhi, Hartung, Thomas, Zhang, Jin, Zhao, Yingming, Colombini, Marco, Liu, Jun O.

“…Itraconazole, a clinically used antifungal drug, was found to possess potent antiangiogenic and anticancer activity that is unique among the azole antifungals…”
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Effect of remimazolam tosilate on the incidence of hypoxemia in elderly patients undergoing gastrointestinal endoscopy: A bi-center, prospective, randomized controlled study by Liu, Fang, Cheng, Xiaoyan, Wang, Yingjie, Li, Kai, Peng, Tianliang, Fang, Ningning, Pasunooti, Kalyan K, Jun, Seungho, Yang, Xiaomei, Wu, Jianbo

“…Remimazolam tosilate is a new ultra-short-acting benzodiazepine sedative medicine. In this study, we evaluated the effect of remimazolam tosilate on the…”
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Divergence of Antiangiogenic Activity and Hepatotoxicity of Different Stereoisomers of Itraconazole by Shim, Joong Sup, Li, Ruo-Jing, Bumpus, Namandje N, Head, Sarah A, Kumar Pasunooti, Kalyan, Yang, Eun Ju, Lv, Junfang, Shi, Wei, Liu, Jun O

“…Itraconazole is a triazole antifungal drug that has recently been found to inhibit angiogenesis. Itraconazole is a relatively well-tolerated drug but shows…”
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Structure-activity relationship study of itraconazole, a broad-range inhibitor of picornavirus replication that targets oxysterol-binding protein (OSBP) by Bauer, Lisa, Ferla, Salvatore, Head, Sarah A., Bhat, Shridhar, Pasunooti, Kalyan K., Shi, Wei Q., Albulescu, Lucian, Liu, Jun O., Brancale, Andrea, van Kuppeveld, Frank J.M., Strating, Jeroen R.P.M.

“…Itraconazole (ITZ) is a well-known, FDA-approved antifungal drug that is also in clinical trials for its anticancer activity. ITZ exerts its anticancer…”
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N-Linked Glycosyl Auxiliary-Mediated Native Chemical Ligation on Aspartic Acid: Application towards N-Glycopeptide Synthesis by Chai, Hua, Le Mai Hoang, Kim, Vu, Minh Duy, Pasunooti, Kalyan, Liu, Chuan-Fa, Liu, Xue-Wei

“…A practical approach towards N‐glycopeptide synthesis using an auxiliary‐mediated dual native chemical ligation (NCL) has been developed. The first NCL…”
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Design, Synthesis, Molecular Docking Study and Biological Evaluation of Novel γ-Carboline Derivatives of Latrepirdine (Dimebon) as Potent Anticancer Agents by Voggu, Ramakrishna, Karmakar, Arundhati, Puli, Venkat Swamy, Damerla, V Surendra Babu, Mogili, Padma, Amaladass, P, Chidara, Sridhar, Pasunooti, Kalyan Kumar, Gupta, Sarika

“…A series of novel γ-Carboline derivatives were designed and synthesized using the Suzuki coupling reaction to identify the leads for the activity against…”
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Benzofuran-based estrogen receptor α modulators as anti-cancer therapeutics: in silico and experimental studies by Leow, Min Li, Chin, Hui Li Christina, Yu, Peggy Shuang, Pasunooti, Kalyan Kumar, Tay, Raymond Xu Zhan, Zhang, Dawei, Yoon, Ho Sup, Liu, Xue-Wei

“…In the search for new estrogen receptor alpha (ERα) modulators, a trial molecular screening was conducted and 5,6-dihydroxybenzofuran was identified as a…”
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Total chemical and semisynthetic approaches for the preparation of ubiquitinated proteins and their applications by Bi, Xiaobao, Pasunooti, Kalyan Kumar, Liu, Chuan-Fa

“…Protein ubiquitination is an important post-translational modification（PTM） in eukaryotic organisms that regulates a variety of cellular processes, such as…”
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Editorial: Design of novel inhibitors for ischemia/reperfusion injury targeting ferroptosis by Wang, Xuyang, Deng, Qiming, Hou, Jingchen, Pasunooti, Kalyan Kumar, Bermea, Kevin, Li, Kai, Ramirez-Correa, Genaro A, Yang, Xiaomei, Wu, Jianbo

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Discovery of tetrahydro γ-carboline based novel glucose uptake agent for the treatment of diabetes and Alzheimer’s diseases by Voggu, Ramakrishna, Devi Balakrishnan, Durga, Shukla, Priyanka, Swamy Puli, Venkat, Surendra Babu Damerla, V., Rajan, Sreekanth, Chidara, Sridhar, Mogili, Padma, Kumar Pasunooti, Kalyan, Gupta, Sarika

“…[Display omitted] •Tetrahydro γ-Carbolines show potential in treating both T2DM and Alzheimer’s disease.•Compound 11a enhances glucose uptake in adipocytes,…”
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Total Synthesis of Sialic Acid by a Sequential Rhodium-Catalyzed Aziridination and Barbier Allylation of D-Glycal by Lorpitthaya, Rujee, Suryawanshi, Sharad B., Wang, Siming, Pasunooti, Kalyan Kumar, Cai, Shuting, Ma, Jimei, Liu, Xue-Wei

“…Acid test: Sialic acid Neu5Ac was synthesized in a regio and stereoselective manner from a glycal (see scheme) via a [1,2,3]‐oxathiazocane‐2,2‐dioxide…”
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Synthesis of 4-mercapto- l-lysine derivatives: Potential building blocks for sequential native chemical ligation by Pasunooti, Kalyan Kumar, Yang, Renliang, Vedachalam, Seenuvasan, Gorityala, Bala Kishan, Liu, Chuan-Fa, Liu, Xue-Wei

“…A general and diastereoselective synthesis of (2 S, 4 S)-4-mercapto- l-lysine derivative was described. The key features of this synthesis include Zn-mediated…”
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A general and mild copper-catalyzed three-component synthesis of protected homoallyl amines by Pasunooti, Kalyan Kumar, Leow, Min Li, Vedachalam, Seenuvasan, Gorityala, Bala Kishan, Liu, Xue-Wei

“…A mild and highly efficient copper-catalyzed, one-pot, three-component reaction is developed for the synthesis of homoallyl amines. Reaction of an aldehyde, a…”
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Facile synthesis and characterization of new polymerizable conjugated 2,5-di(selenophen-2-yl)pyrroles and 2,5-difuranylpyrroles by Amaladass, Pitchamuthu, Pasunooti, Kalyan Kumar, Png, Zihuan, Liu, Xue-Wei

“…A facile synthesis of novel π-conjugated 2,5-di(selenophen-2-yl)pyrroles (SeNSe) and 2,5-difuranylpyrroles (ONO) via Paal–Knorr reaction as the key step is…”
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Auxiliary-Directed Pd-Catalyzed γ‑C(sp3)–H Bond Activation of α‑Aminobutanoic Acid Derivatives by Pasunooti, Kalyan Kumar, Banerjee, Biplab, Yap, Terence, Jiang, Yaojia, Liu, Chuan-Fa

“…New bidentate auxiliaries derived from the isoxazole-3-carboxamide and oxazole-4-carboxamide moieties were used for Pd-catalyzed C­(sp3)–H bond activation. The…”
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Amidative Cyclization of Alkynyl Esters to Access Pyrazin-1(2H)‑ones: Application to the Synthesis of Peramine and Dibromophakellin by Gangnale, Laxmikant D., Miriyala, Satya Ravi Teja, Pasunooti, Kalyan Kumar, Reddy, D. Srinivasa

“…Herein, we report an efficient 1,5,7-Triazabicyclo[4.4.0]­dec-5-ene (TBD)-catalyzed tandem intermolecular amidation and regioselective intramolecular 6-exo-dig…”
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Dual Native Chemical Ligation at Lysine by Yang, Renliang, Pasunooti, Kalyan Kumar, Li, Fupeng, Liu, Xue-Wei, Liu, Chuan-Fa

“…A thiol group introduced on the γ-carbon of lysine mediates robust native chemical ligation at both the α- and ε-amines in two consecutive steps…”
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5‑Methylisoxazole-3-carboxamide-Directed Palladium-Catalyzed γ‑C(sp3)–H Acetoxylation and Application to the Synthesis of γ‑Mercapto Amino Acids for Native Chemical Ligation by Pasunooti, Kalyan Kumar, Yang, Renliang, Banerjee, Biplab, Yap, Terence, Liu, Chuan-Fa

“…Palladium-catalyzed acetoxylation of the primary γ-C­(sp3)–H bonds in the amino acids Val, Thr, and Ile was achieved using a newly discovered…”
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A microwave-assisted, copper-catalyzed three-component synthesis of dihydropyrimidinones under mild conditions by Pasunooti, Kalyan Kumar, Chai, Hua, Jensen, Chantel Nixon, Gorityala, Bala Kishan, Wang, Siming, Liu, Xue-Wei

“…The synthesis of dihydropyrimidinones via a clean multi-component Biginelli reaction under microwave irradiation is reported. The copper-catalyzed process…”
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