Influence of UV nail lamps radiation on human keratinocytes viability

Ultraviolet nail lamps are becoming increasingly popular, however, the safety of their use remains controversial. The following article directly responds to recently published literature data and aims to determine the viability of human keratinocytes irradiated by a UV nail-drying machine. Cells wer...

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Bibliographic Details
Published in:	Scientific reports Vol. 13; no. 1; p. 22530
Main Authors:	Słabicka-Jakubczyk, Anna, Lewandowski, Miłosz, Pastuszak, Paulina, Barańska-Rybak, Wioletta, Górska-Ponikowska, Magdalena
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 18-12-2023 Nature Publishing Group Nature Portfolio
Subjects:	631/80 631/92 692/308 692/4017 692/700 Cell viability Drying Humanities and Social Sciences Humans Irradiation Keratinocytes Keratinocytes - radiation effects multidisciplinary Nails Radiation Science Science (multidisciplinary) Skin Neoplasms Sunscreen Sunscreening Agents - pharmacology Ultraviolet radiation Ultraviolet Rays - adverse effects
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Summary:	Ultraviolet nail lamps are becoming increasingly popular, however, the safety of their use remains controversial. The following article directly responds to recently published literature data and aims to determine the viability of human keratinocytes irradiated by a UV nail-drying machine. Cells were exposed to 365–405 nm wavelength UV light emitted by a nail drying machine in two time variants: 4 and 20 min, with and without sunscreen cream SPF50 protection, and compared to the untreated control. Compared to the control, cell viability after irradiation for 4 min decreased insignificantly ( p < 0.1), however for 20 min decreased by 35% ( p < 0.0001). Furthermore, cells with sunscreen protection compared to those without showed significantly increased viability, regardless of time-variant ( p < 0.0001). The study shows that 4-min irradiation does not significantly reduce the viability of human keratinocytes and the time of 20 min significantly alters the research results compared to 4 min, which corresponds to real conditions. The results suggest that typical manicure exposure time does not significantly affect keratinocyte viability, which could increase the risk of developing skin cancers. Despite the above results, it is recommended to use sunscreen protection on your hands during the procedure, which significantly increases the viability of keratinocytes during ultraviolet nail lamp radiation.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	2045-2322 2045-2322
DOI:	10.1038/s41598-023-49814-7