Search Results - "Pastorek, Jaromír"

Hypoxia-induced carbonic anhydrase IX as a target for cancer therapy: From biology to clinical use by Pastorek, Jaromir, Pastorekova, Silvia

“…Abstract The tumor microenvironment includes a complicated network of physiological gradients contributing to plasticity of tumor cells and heterogeneity of…”
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Gastric hyperplasia in mice with targeted disruption of the carbonic anhydrase gene Car9 by Gut, Marta Ortova, Parkkila, Seppo, Vernerová, Zdeòka, Rohde, Elvira, Závada, Jan, Höcker, Michael, Pastorek, Jaromír, Karttunen, Tuomo, Gibadulinová, Adriana, Závadová, Zuzana, Knobeloch, Klaus–Peter, Wiedenmann, Bertram, Svoboda, Jan, Horak, Ivan, Pastoreková, Silvia

“…Background & Aims: Carbonic anhydrase (CA) IX is a highly active enzyme with adhesion capacity that is functionally implicated in acid-base balance and…”
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Carbonic anhydrase IX: regulation and role in cancer by Benej, Martin, Pastorekova, Silvia, Pastorek, Jaromir

“…Tumor microenvironment substantially influences the process of tumorigenesis. In many solid tumors, imbalance between the demand of rapidly proliferating…”
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Expression of carbonic anhydrase IX in breast is associated with malignant tissues and is related to overexpression of c-erbB2 by Bartošová, Mária, Parkkila, Seppo, Pohlodek, Kamil, Karttunen, Tuomo J., Galbavý, Štefan, Mucha, Vojtech, Harris, Adrian L., Pastorek, Jaromír, Pastoreková, Silvia

“…CA IX is a tumour‐associated carbonic anhydrase with proposed roles in pH modulation and intercellular communication. Its distribution was examined in normal,…”
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Crystal Structure of the Catalytic Domain of the Tumor-Associated Human Carbonic Anhydrase IX by Alterio, Vincenzo, Hilvo, Mika, Di Fiore, Anna, Supuran, Claudiu T., Pan, Peiwen, Parkkila, Seppo, Scaloni, Andrea, Pastorek, Jaromir, Pastorekova, Silvia, Pedone, Carlo, Scozzafava, Andrea, Monti, Simona Maria, De Simone, Giuseppina, Sly, William S.

“…Carbonic anhydrase (CA) IX is a plasma membrane-associated member of the α-CA enzyme family, which is involved in solid tumor acidification. It is a marker of…”
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Hypoxia activates the capacity of tumor-associated carbonic anhydrase IX to acidify extracellular pH by Švastová, Eliška, Hulı́ková, Alžbeta, Rafajová, Monika, Zat'ovičová, Miriam, Gibadulinová, Adriana, Casini, Angela, Cecchi, Alessandro, Scozzafava, Andrea, Supuran, Claudiu T., Pastorek, Jaromı́r, Pastoreková, Silvia

“…Acidic extracellular pH (pHe) is a typical attribute of a tumor microenviroment, which has an impact on cancer development and treatment outcome. It was…”
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Propranolol, Promising Chemosensitizer and Candidate for the Combined Therapy through Disruption of Tumor Microenvironment Homeostasis by Decreasing the Level of Carbonic Anhydrase IX by Puzderova, Barbora, Belvoncikova, Petra, Grossmannova, Katarina, Csaderova, Lucia, Labudova, Martina, Fecikova, Silvia, Pastorek, Jaromir, Barathova, Monika

“…Resistance to chemotherapy represents a persisting medical problem, ranking among main causes of chemotherapy failure and cancer mortality. There is a…”
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Monoclonal antibodies generated in carbonic anhydrase IX-deficient mice recognize different domains of tumour-associated hypoxia-induced carbonic anhydrase IX by Zat'ovičová, Miriam, Tarábková, Kvetoslava, Švastová, Eliška, Gibadulinová, Adriana, Mucha, Vojtech, Jakubı́čková, Lýdia, Biesová, Zuzana, Rafajová, Monika, Ortova Gut, Marta, Parkkila, Seppo, Parkkila, Anna-Kaisa, Waheed, Abdul, Sly, Willam S., Horak, Ivan, Pastorek, Jaromı́r, Pastoreková, Silvia

“…Transmembrane carbonic anhydrase IX (CA IX) is frequently expressed in human tumours in response to hypoxia and may serve as a tumour marker and therapeutic…”
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Impairment of Hypoxia-Induced CA IX by Beta-Blocker Propranolol-Impact on Progression and Metastatic Potential of Colorectal Cancer Cells by Barathova, Monika, Grossmannova, Katarina, Belvoncikova, Petra, Kubasova, Veronika, Simko, Veronika, Skubla, Rudolf, Csaderova, Lucia, Pastorek, Jaromir

“…The coexistence of cancer and other concomitant diseases is very frequent and has substantial implications for treatment decisions and outcomes. Beta-blockers,…”
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Impairment of carbonic anhydrase IX ectodomain cleavage reinforces tumorigenic and metastatic phenotype of cancer cells by Kajanova, Ivana, Zatovicova, Miriam, Jelenska, Lenka, Sedlakova, Olga, Barathova, Monika, Csaderova, Lucia, Debreova, Michaela, Lukacikova, Lubomira, Grossmannova, Katarina, Labudova, Martina, Golias, Tereza, Svastova, Eliska, Ludwig, Andreas, Muller, Petr, Vojtesek, Borivoj, Pastorek, Jaromir, Pastorekova, Silvia

“…Background Carbonic anhydrase IX (CA IX) is a hypoxia-induced enzyme regulating tumour pH and facilitating cell migration/invasion. It is primarily expressed…”
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Carbonic anhydrase inhibitors. Inhibition of the transmembrane isozyme XII with sulfonamides—a new target for the design of antitumor and antiglaucoma drugs? by Vullo, Daniela, Innocenti, Alessio, Nishimori, Isao, Pastorek, Jaromı́r, Scozzafava, Andrea, Pastoreková, Silvia, Supuran, Claudiu T.

“…[Display omitted] The inhibition of a newly cloned human carbonic anhydrase (CA, EC 4.2.1.1), isozyme XII (hCA XII), has been investigated with a series of…”
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Carbonic anhydrase enzymes Ⅱ, Ⅶ, Ⅸ and Ⅻ in colorectal carcinomas by Viikilä, Pia, Kivelä, Antti J, Mustonen, Harri, Koskensalo, Selja, Waheed, Abdul, Sly, William S, Pastorek, Jaromir, Pastorekova, Silvia, Parkkila, Seppo, Haglund, Caj

“…AIM To investigate expression of four alpha-carbonic anhydrases(CAs) in colorectal carcinomas(CRC) and compare the results with patients’ survival.METHODS…”
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Phosphorylation of Carbonic Anhydrase IX Controls Its Ability to Mediate Extracellular Acidification in Hypoxic Tumors by DITTE, Peter, DEQUIEDT, Franck, PASTOREK, Jaromir, SVASTOVA, Eliska, HULIKOVA, Alzbeta, OHRADANOVA-REPIC, Anna, ZATOVICOVA, Miriam, CSADEROVA, Lucia, KOPACEK, Juraj, SUPURAN, Claudiu T, PASTOREKOVA, Silvia

“…In the hypoxic regions of a tumor, carbonic anhydrase IX (CA IX) is an important transmembrane component of the pH regulatory machinery that participates in…”
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Hypoxia Marker Carbonic Anhydrase IX Is Present in Abdominal Aortic Aneurysm Tissue and Plasma by Grossmannova, Katarina, Barathova, Monika, Belvoncikova, Petra, Lauko, Viliam, Csaderova, Lucia, Tomka, Jan, Dulka, Tomas, Pastorek, Jaromir, Madaric, Juraj

“…Abdominal aortic aneurysms (AAA) are a significant cause of premature deaths worldwide. Since there is no specific treatment for reducing AAA progression, it…”
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Transcriptional regulation and functional implication of S100P in cancer by Gibadulinova, Adriana, Tothova, Veronika, Pastorek, Jaromir, Pastorekova, Silvia

“…S100P is an EF-hand calcium-binding protein that was originally identified in placenta and subsequently associated with cancer. It is a member of S100 family…”
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PIMT Binding to C-Terminal Ala459 of CAIX Is Involved in Inside-Out Signaling Necessary for Its Catalytic Activity by Simko, Veronika, Belvoncikova, Petra, Csaderova, Lucia, Labudova, Martina, Grossmannova, Katarina, Zatovicova, Miriam, Kajanova, Ivana, Skultety, Ludovit, Barathova, Monika, Pastorek, Jaromir

“…Human carbonic anhydrase IX (CAIX), a unique member of the α carbonic anhydrase family, is a transmembrane glycoprotein with high enzymatic activity by which…”
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Biochemical Characterization of CA IX, One of the Most Active Carbonic Anhydrase Isozymes by Hilvo, Mika, Baranauskiene, Lina, Salzano, Anna Maria, Scaloni, Andrea, Matulis, Daumantas, Innocenti, Alessio, Scozzafava, Andrea, Monti, Simona Maria, Di Fiore, Anna, De Simone, Giuseppina, Lindfors, Mikaela, Jänis, Janne, Valjakka, Jarkko, Pastoreková, Silvia, Pastorek, Jaromir, Kulomaa, Markku S., Nordlund, Henri R., Supuran, Claudiu T., Parkkila, Seppo

“…Carbonic anhydrase IX (CA IX) is an exceptional member of the CA protein family; in addition to its classical role in pH regulation, it has also been proposed…”
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Apoptosis-induced ectodomain shedding of hypoxia-regulated carbonic anhydrase IX from tumor cells: a double-edged response to chemotherapy by Vidlickova, Ivana, Dequiedt, Franck, Jelenska, Lenka, Sedlakova, Olga, Pastorek, Michal, Stuchlik, Stanislav, Pastorek, Jaromir, Zatovicova, Miriam, Pastorekova, Silvia

“…Carbonic anhydrase IX (CA IX) is a tumor-associated, highly active, transmembrane carbonic anhydrase isoform regulated by hypoxia and implicated in pH control…”
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Molecular mechanisms of carbonic anhydrase IX‐mediated pH regulation under hypoxia by Pastorekova, Silvia, Ratcliffe, Peter J., Pastorek, Jaromir

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Carbonic Anhydrase Inhibitors. Design of Fluorescent Sulfonamides as Probes of Tumor-Associated Carbonic Anhydrase IX That Inhibit Isozyme IX-Mediated Acidification of Hypoxic Tumors by Cecchi, Alessandro, Hulikova, Alzbeta, Pastorek, Jaromír, Pastoreková, Silvia, Scozzafava, Andrea, Winum, Jean-Yves, Montero, Jean-Louis, Supuran, Claudiu T

“…Sulfonamides inhibit the catalytic activity of carbonic anhydrases (CAs, EC 4.2.1.1), enzymes participating in the regulation of acid−base balance and ion…”
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