Search Results - "Pastor‐Soler, Nuria"

Metformin improves relevant disease parameters in an autosomal dominant polycystic kidney disease mouse model by Pastor-Soler, Núria M, Li, Hui, Pham, Jessica, Rivera, Daniel, Ho, Pei-Yin, Mancino, Valeria, Saitta, Biagio, Hallows, Kenneth R

“…Autosomal dominant polycystic kidney disease (ADPKD), caused by mutations in the polycystin 1 ( ) or polycystin 2 genes, presents with progressive development…”
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Shear stress-dependent regulation of apical endocytosis in renal proximal tubule cells mediated by primary cilia by Raghavan, Venkatesan, Rbaibi, Youssef, Pastor-Soler, Núria M., Carattino, Marcelo D., Weisz, Ora A.

“…The kidney has an extraordinary ability to maintain stable fractional solute and fluid reabsorption over a wide range of glomerular filtration rates (GFRs)…”
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Activation of AMP‐activated protein kinase during sepsis/inflammation improves survival by preserving cellular metabolic fitness by Jin, Kui, Ma, Yujie, Manrique‐Caballero, Carlos L., Li, Hui, Emlet, David R., Li, Shengnan, Baty, Catherine J., Wen, Xiaoyan, Kim‐Campbell, Nahmah, Frank, Alicia, Menchikova, Elizabeth V., Pastor‐Soler, Nuria M., Hallows, Kenneth R., Jackson, Edwin K., Shiva, Sruti, Pinsky, Michael R., Zuckerbraun, Brian S., Kellum, John A., Gómez, Hernando

“…The purpose was to determine the role of AMPK activation in the renal metabolic response to sepsis, the development of sepsis‐induced acute kidney injury (AKI)…”
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Extracorporeal Therapy for Dabigatran Removal in the Treatment of Acute Bleeding: A Single Center Experience by Singh, Tripti, Maw, Thin Thin, Henry, Brian L, Pastor-Soler, Núria M, Unruh, Mark L, Hallows, Kenneth R, Nolin, Thomas D

“…Dabigatran is an oral direct thrombin inhibitor that is Food and Drug Administration-approved for prevention of stroke in patients with atrial fibrillation. No…”
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Role of the energy sensor AMP-activated protein kinase in renal physiology and disease by Hallows, Kenneth R, Mount, Peter F, Pastor-Soler, Núria M, Power, David A

“…The ultrasensitive energy sensor AMP-activated protein kinase (AMPK) orchestrates the regulation of energy-generating and energy-consuming pathways. AMPK is…”
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Alternatively spliced proline-rich cassettes link WNK1 to aldosterone action by Roy, Ankita, Al-Qusairi, Lama, Donnelly, Bridget F, Ronzaud, Caroline, Marciszyn, Allison L, Gong, Fan, Chang, Y P Christy, Butterworth, Michael B, Pastor-Soler, Núria M, Hallows, Kenneth R, Staub, Olivier, Subramanya, Arohan R

“…The thiazide-sensitive NaCl cotransporter (NCC) is important for renal salt handling and blood-pressure homeostasis. The canonical NCC-activating pathway…”
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Generation of patterned kidney organoids that recapitulate the adult kidney collecting duct system from expandable ureteric bud progenitors by Zeng, Zipeng, Huang, Biao, Parvez, Riana K., Li, Yidan, Chen, Jyunhao, Vonk, Ariel C., Thornton, Matthew E., Patel, Tadrushi, Rutledge, Elisabeth A., Kim, Albert D., Yu, Jingying, Grubbs, Brendan H., McMahon, Jill A., Pastor-Soler, Nuria M., Hallows, Kenneth R., McMahon, Andrew P., Li, Zhongwei

“…Current kidney organoids model development and diseases of the nephron but not the contiguous epithelial network of the kidney’s collecting duct (CD) system…”
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AMP-activated protein kinase inhibits alkaline pH- and PKA-induced apical vacuolar H+-ATPase accumulation in epididymal clear cells by Hallows, Kenneth R, Alzamora, Rodrigo, Li, Hui, Gong, Fan, Smolak, Christy, Neumann, Dietbert, Pastor-Soler, Núria M

“…Acidic luminal pH and low [HCO(3)(-)] maintain sperm quiescent during maturation in the epididymis. The vacuolar H(+)-ATPase (V-ATPase) in clear cells is a…”
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PKA Regulates Vacuolar H+-ATPase Localization and Activity via Direct Phosphorylation of the A Subunit in Kidney Cells by Alzamora, Rodrigo, Thali, Ramon F., Gong, Fan, Smolak, Christy, Li, Hui, Baty, Catherine J., Bertrand, Carol A., Auchli, Yolanda, Brunisholz, René A., Neumann, Dietbert, Hallows, Kenneth R., Pastor-Soler, Núria M.

“…The vacuolar H+-ATPase (V-ATPase) is a major contributor to luminal acidification in epithelia of Wolffian duct origin. In both kidney-intercalated cells and…”
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Alkaline pH- and cAMP-induced V-ATPase membrane accumulation is mediated by protein kinase A in epididymal clear cells by Pastor-Soler, Núria M, Hallows, Kenneth R, Smolak, Christy, Gong, Fan, Brown, Dennis, Breton, Sylvie

“…In the epididymis, low luminal bicarbonate and acidic pH maintain sperm quiescent during maturation and storage. The vacuolar H(+)-ATPase (V-ATPase) in…”
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AMP-activated protein kinase regulates the vacuolar H+-ATPase via direct phosphorylation of the A subunit (ATP6V1A) in the kidney by Alzamora, Rodrigo, Al-Bataineh, Mohammad M, Liu, Wen, Gong, Fan, Li, Hui, Thali, Ramon F, Joho-Auchli, Yolanda, Brunisholz, René A, Satlin, Lisa M, Neumann, Dietbert, Hallows, Kenneth R, Pastor-Soler, Núria M

“…The vacuolar H(+)-ATPase (V-ATPase) in intercalated cells contributes to luminal acidification in the kidney collecting duct and nonvolatile acid excretion. We…”
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Regulation of proximal tubule vacuolar H(+)-ATPase by PKA and AMP-activated protein kinase by Al-bataineh, Mohammad M, Gong, Fan, Marciszyn, Allison L, Myerburg, Michael M, Pastor-Soler, Núria M

“…The vacuolar H(+)-ATPase (V-ATPase) mediates ATP-driven H(+) transport across membranes. This pump is present at the apical membrane of kidney proximal tubule…”
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Muc1 enhances the β-catenin protective pathway during ischemia-reperfusion injury by Al-Bataineh, Mohammad M, Kinlough, Carol L, Poland, Paul A, Pastor-Soler, Núria M, Sutton, Timothy A, Mang, Henry E, Bastacky, Sheldon I, Gendler, Sandra J, Madsen, Cathy S, Singh, Sucha, Monga, Satdarshan P, Hughey, Rebecca P

“…The hypoxia-inducible factor (HIF)-1 and β-catenin protective pathways represent the two most significant cellular responses that are activated in response to…”
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Activation of the metabolic sensor AMP-activated protein kinase inhibits aquaporin-2 function in kidney principal cells by Al-Bataineh, Mohammad M, Li, Hui, Ohmi, Kazuhiro, Gong, Fan, Marciszyn, Allison L, Naveed, Sajid, Zhu, Xiaoqing, Neumann, Dietbert, Wu, Qi, Cheng, Lei, Fenton, Robert A, Pastor-Soler, Núria M, Hallows, Kenneth R

“…Aquaporin-2 (AQP2) is essential to maintain body water homeostasis. AQP2 traffics from intracellular vesicles to the apical membrane of kidney collecting duct…”
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Regulation of the creatine transporter by AMP-activated protein kinase in kidney epithelial cells by Li, Hui, Thali, Ramon F, Smolak, Christy, Gong, Fan, Alzamora, Rodrigo, Wallimann, Theo, Scholz, Roland, Pastor-Soler, Núria M, Neumann, Dietbert, Hallows, Kenneth R

“…The metabolic sensor AMP-activated protein kinase (AMPK) regulates several transport proteins, potentially coupling transport activity to cellular stress and…”
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SGLT1, a novel cardiac glucose transporter, mediates increased glucose uptake in PRKAG2 cardiomyopathy by Banerjee, Sanjay K, Wang, David W, Alzamora, Rodrigo, Huang, Xueyin N, Pastor-Soler, Núria M, Hallows, Kenneth R, McGaffin, Kenneth R, Ahmad, Ferhaan

“…Abstract Human mutations in the gene PRKAG2 encoding the γ2 subunit of AMP-activated protein kinase (AMPK) cause a glycogen storage cardiomyopathy. Transgenic…”
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Aurora kinase A activates the vacuolar H+-ATPase (V-ATPase) in kidney carcinoma cells by Al-Bataineh, Mohammad M, Alzamora, Rodrigo, Ohmi, Kazuhiro, Ho, Pei-Yin, Marciszyn, Allison L, Gong, Fan, Li, Hui, Hallows, Kenneth R, Pastor-Soler, Núria M

“…Extracellular proton-secreting transport systems that contribute to extracellular pH include the vacuolar H(+)-ATPase (V-ATPase). This pump, which mediates…”
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Epithelial transport during septic acute kidney injury by Morrell, Eric D, Kellum, John A, Hallows, Kenneth R, Pastor-Soler, Núria M

“…A goal for scientists studying septic acute kidney injury (AKI) should be to formulate a conceptual model of disease that is able to coherently reconcile the…”
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Aquaporin 9 expression in the developing rat epididymis is modulated by steroid hormones by Pastor-Soler, Núria M, Fisher, Jane S, Sharpe, Richard, Hill, Eric, Van Hoek, Alfred, Brown, Dennis, Breton, Sylvie

“…Fluid and solute transport across the epithelium of the male excurrent duct is important for sperm maturation and storage. Aquaporin 9 (AQP9), which allows…”
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AMP-activated protein kinase inhibits KCNQ1 channels through regulation of the ubiquitin ligase Nedd4-2 in renal epithelial cells by Alzamora, Rodrigo, Gong, Fan, Rondanino, Christine, Lee, Jeffrey K, Smolak, Christy, Pastor-Soler, Núria M, Hallows, Kenneth R

“…The KCNQ1 K(+) channel plays a key role in the regulation of several physiological functions, including cardiac excitability, cardiovascular tone, and body…”
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