Search Results - "Pasto, Anna"

Exosome-like Nanovectors for Drug Delivery in Cancer by Arrighetti, Noemi, Corbo, Claudia, Evangelopoulos, Michael, Pastò, Anna, Zuco, Valentina, Tasciotti, Ennio

“…Cancer treatment still represents a formidable challenge, despite substantial advancements in available therapies being made over the past decade. One major…”
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Autophagy inhibition reduces chemoresistance and tumorigenic potential of human ovarian cancer stem cells by Pagotto, Anna, Pilotto, Giorgia, Mazzoldi, Elena Laura, Nicoletto, Maria Ornella, Frezzini, Simona, Pastò, Anna, Amadori, Alberto

“…Epithelial ovarian cancer (EOC) is one of the most malignant gynecological tumors with a high mortality rate owing to tumor relapse after anticancer therapies…”
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A juxtacrine/paracrine loop between C-Kit and stem cell factor promotes cancer stem cell survival in epithelial ovarian cancer by Mazzoldi, Elena Laura, Pavan, Simona, Pilotto, Giorgia, Leone, Kevin, Pagotto, Anna, Frezzini, Simona, Nicoletto, Maria Ornella, Amadori, Alberto, Pastò, Anna

“…Receptors tyrosine kinase (RTK) enable normal and tumor cells to perceive and adapt to stimuli present in the microenvironment. These stimuli, also known as…”
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Macrophage-derived nanovesicles exert intrinsic anti-inflammatory properties and prolong survival in sepsis through a direct interaction with macrophages by Molinaro, Roberto, Pastò, Anna, Corbo, Claudia, Taraballi, Francesca, Giordano, Federica, Martinez, Jonathan O, Zhao, Picheng, Wang, Xin, Zinger, Assaf, Boada, Christian, Hartman, Kelly A, Tasciotti, Ennio

“…Despite numerous advances in medical treatment, sepsis remains one of the leading causes of death worldwide. Sepsis is characterized by the involvement of all…”
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Prolonged exposure to simulated microgravity promotes stemness impairing morphological, metabolic and migratory profile of pancreatic cancer cells: a comprehensive proteomic, lipidomic and transcriptomic analysis by Masini, Maria Angela, Bonetto, Valentina, Manfredi, Marcello, Pastò, Anna, Barberis, Elettra, Timo, Sara, Vanella, Virginia Vita, Robotti, Elisa, Masetto, Francesca, Andreoli, Francesca, Fiore, Alessandra, Tavella, Sara, Sica, Antonio, Donadelli, Massimo, Marengo, Emilio

“…Background The impact of the absence of gravity on cancer cells is of great interest, especially today that space is more accessible than ever. Despite…”
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Casein Kinase 1 Delta Regulates Cell Proliferation, Response to Chemotherapy and Migration in Human Ovarian Cancer Cells by Mazzoldi, Elena Laura, Pastò, Anna, Ceppelli, Elisa, Pilotto, Giorgia, Barbieri, Vito, Amadori, Alberto, Pavan, Simona

“…Casein kinase 1 delta (CK1δ) has a tumor-promoting role in different cancers and it is genetically amplified in a portion of human epithelial ovarian cancer…”
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Cell membrane protein functionalization of nanoparticles as a new tumor-targeting strategy by Pasto, Anna, Giordano, Federica, Evangelopoulos, Michael, Amadori, Alberto, Tasciotti, Ennio

“…Nanoparticles have seen considerable popularity as effective tools for drug delivery. However, non-specific targeting continues to remain a challenge…”
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VEGF-targeted therapy stably modulates the glycolytic phenotype of tumor cells by Curtarello, Matteo, Zulato, Elisabetta, Nardo, Giorgia, Valtorta, Silvia, Guzzo, Giulia, Rossi, Elisabetta, Esposito, Giovanni, Msaki, Aichi, Pastò, Anna, Rasola, Andrea, Persano, Luca, Ciccarese, Francesco, Bertorelle, Roberta, Todde, Sergio, Plebani, Mario, Schroer, Henrike, Walenta, Stefan, Mueller-Klieser, Wolfgang, Amadori, Alberto, Moresco, Rosa Maria, Indraccolo, Stefano

“…Anti-VEGF therapy perturbs tumor metabolism, severely impairing oxygen, glucose, and ATP levels. In this study, we investigated the effects of anti-VEGF…”
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Biomimetic Nanoparticles Potentiate the Anti-Inflammatory Properties of Dexamethasone and Reduce the Cytokine Storm Syndrome: An Additional Weapon against COVID-19? by Molinaro, Roberto, Pasto, Anna, Taraballi, Francesca, Giordano, Federica, Azzi, Jamil A., Tasciotti, Ennio, Corbo, Claudia

“…Recent studies on coronavirus infectious disease 2019 (COVID-19) pathophysiology indicated the cytokine release syndrome induced by the virus as the main cause…”
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Correlation of the treatment sensitivity of patient-derived organoids with treatment outcomes in patients with head and neck cancer (SOTO): protocol for a prospective observational study by Vasiliadou, Ifigenia, Cattaneo, Christiana, Chan, Phoebe Yuen Ka, Henley-Smith, Rhonda, Gregson-Williams, Harry, Collins, Lisette, Wojewodka, Gabriella, Guerrero-Urbano, Teresa, Jeannon, Jean-Pierre, Connor, Steve, Davis, Jessica, Pasto, Anna, Mustapha, Rami, Ng, Tony, Kong, Anthony

“…IntroductionOrganoids have been successfully used in several areas of cancer research and large living biobanks of patient-derived organoids (PDOs) have been…”
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Resistance to glucose starvation as metabolic trait of platinum-resistant human epithelial ovarian cancer cells by Pastò, Anna, Pagotto, Anna, Pilotto, Giorgia, De Paoli, Angela, De Salvo, Gian Luca, Baldoni, Alessandra, Nicoletto, Maria Ornella, Ricci, Francesca, Damia, Giovanna, Bellio, Chiara, Indraccolo, Stefano, Amadori, Alberto

“…Deregulated glucose metabolism is observed in cancer but whether this metabolic trait influences response to or is modulated by cytotoxic drugs is unknown. We…”
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Bioinspired Extracellular Vesicles: Lessons Learned From Nature for Biomedicine and Bioengineering by Zinger, Assaf, Brozovich, Ava, Pasto, Anna, Sushnitha, Manuela, Martinez, Jonathan O, Evangelopoulos, Michael, Boada, Christian, Tasciotti, Ennio, Taraballi, Francesca

“…Efficient communication is essential in all layers of the biological chain. Cells exchange information using a variety of signaling moieties, such as small…”
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Immunomodulatory biomimetic nanoparticles target articular cartilage trauma after systemic administration by Mancino, Chiara, Pasto, Anna, De Rosa, Enrica, Dolcetti, Luigi, Rasponi, Marco, McCulloch, Patrick, Taraballi, Francesca

“…Post-traumatic osteoarthritis (PTOA) is one of the leading causes of disability in developed countries and accounts for 12% of all osteoarthritis cases in the…”
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Comparison of the Genomic Profile of Cancer Stem Cells and Their Non-Stem Counterpart: The Case of Ovarian Cancer by Mazzoldi, Elena Laura, Pastò, Anna, Pilotto, Giorgia, Minuzzo, Sonia, Piga, Ilaria, Palumbo, Pietro, Carella, Massimo, Frezzini, Simona, Nicoletto, Maria Ornella, Amadori, Alberto, Indraccolo, Stefano

“…The classical cancer stem cell (CSC) model places CSCs at the apex of a hierarchical scale, suggesting different genetic alterations in non-CSCs compared to…”
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Influence of Innate Immunity on Cancer Cell Stemness by Pastò, Anna, Consonni, Francesca Maria, Sica, Antonio

“…Even if cancer stem cells (CSCs) represent only a small proportion of the tumor mass, they significantly account for tumor maintenance, resistance to…”
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Tumor-associated myeloid cells as guiding forces of cancer cell stemness by Sica, Antonio, Porta, Chiara, Amadori, Alberto, Pastò, Anna

“…Due to their ability to differentiate into various cell types and to support tissue regeneration, stem cells simultaneously became the holy grail of…”
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Cancer stem cells from epithelial ovarian cancer patients privilege oxidative phosphorylation, and resist glucose deprivation by Pastò, Anna, Bellio, Chiara, Pilotto, Giorgia, Ciminale, Vincenzo, Silic-Benussi, Micol, Guzzo, Giulia, Rasola, Andrea, Frasson, Chiara, Nardo, Giorgia, Zulato, Elisabetta, Nicoletto, Maria Ornella, Manicone, Mariangela, Indraccolo, Stefano, Amadori, Alberto

“…We investigated the metabolic profile of cancer stem cells (CSC) isolated from patients with epithelial ovarian cancer. CSC overexpressed genes associated with…”
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Nanotechnology in the Treatment of Inflammatory Bowel Disease by Giron, Fanny, Pastó, Anna, Tasciotti, Ennio, Abraham, Bincy P

“…Nanotechnology is an emerging field where nanometer particles can be used to deliver medications directly to the area of inflammation thus avoiding…”
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NOTCH3 Signaling Regulates MUSASHI-1 Expression in Metastatic Colorectal Cancer Cells by PASTO, Anna, SERAFIN, Valentina, PINAZZA, Marica, AGOSTINI, Marco, NITTI, Donato, AMADORI, Alberto, INDRACCOLO, Stefano, PILOTTO, Giorgia, LAGO, Claudia, BELLIO, Chiara, TRUSOLINO, Livio, BERTOTTI, Andrea, HOEY, Timothy, PLATEROTI, Michelina, ESPOSITO, Giovanni

“…MUSASHI-1 (MSI-1) is a well-established stem cell marker in both normal and malignant colon cells and it acts by positively regulating the NOTCH pathway…”
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Expression Profiling of Circulating Microvesicles Reveals Intercellular Transmission of Oncogenic Pathways by Milani, Gloria, Lana, Tobia, Bresolin, Silvia, Aveic, Sanja, Pastò, Anna, Frasson, Chiara, Te Kronnie, Geertruy

“…Circulating microvesicles have been described as important players in cell-to-cell communication carrying biological information under normal or pathologic…”
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