Search Results - "Pasternak, J Alex"

Metabolism of activated T lymphocytes by Maciolek, Jason A, Alex Pasternak, J, Wilson, Heather L

“…Graphical abstract…”
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Effects of porcine reproductive and respiratory syndrome virus (PRRSV) on thyroid hormone metabolism in the late gestation fetus by Ison, Erin K, Hopf-Jannasch, Amber S, Harding, John C. S, Alex Pasternak, J

“…Abstract Porcine reproductive and respiratory syndrome virus (PRRSV) in late gestation causes a profound suppression of circulating maternal and fetal thyroid…”
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Fetal cytokine response to porcine reproductive and respiratory syndrome virus-2 infection by Alex Pasternak, J., MacPhee, Daniel J., Harding, John C.S.

“…•Fetal immune response during maternal PRRSV infection is largely restricted to infected fetuses.•Over expression of CCL5 is associated with disease…”
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Late gestation fetal hypothyroidism alters cell cycle regulation across multiple organ systems by Smith, Alyssa A, Vesey, Alexa, Helfrich, Caden, Pasternak, J Alex

“…Hypothyroidism is a common endocrine disruption observed in utero that adversely affects fetal growth and maturation leading to long-term impacts on health;…”
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Maternal and fetal thyroid dysfunction following porcine reproductive and respiratory syndrome virus2 infection by Pasternak, J Alex, MacPhee, Daniel J, Harding, John C S

“…To better understand the host response to porcine reproductive and respiratory virus-2 (PRRSV2) we evaluated circulating thyroid hormone and associated gene…”
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Porcine reproductive and respiratory virus 2 infection of the fetus results in multi-organ cell cycle suppression by Mulligan, Margaret K, Kleiman, Jocelyn E, Caldemeyer, Andrew C, Harding, John C S, Pasternak, J Alex

“…Porcine reproductive and respiratory syndrome virus (PRRSV) infection during late gestation negatively affects fetal development. The objective of this study…”
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In vivo synthesis of bacterial amyloid curli contributes to joint inflammation during S. Typhimurium infection by Miller, Amanda L, Pasternak, J. Alex, Medeiros, Nicole J, Nicastro, Lauren K, Tursi, Sarah A, Hansen, Elizabeth G, Krochak, Ryan, Sokaribo, Akosiererem S, MacKenzie, Keith D, Palmer, Melissa B, Herman, Dakoda J, Watson, Nikole L, Zhang, Yi, Wilson, Heather L, Wilson, R. Paul, White, Aaron P, Tükel, Çagla, Knodler, Leigh, Tsolis, Renée M

“…Reactive arthritis, an autoimmune disorder, occurs following gastrointestinal infection with invasive enteric pathogens, such as Salmonella enterica. Curli, an…”
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A DIO2 missense mutation and its impact on fetal response to PRRSV infection by Ko, Haesu, Pasternak, J Alex, Mulligan, Margaret K, Hamonic, Glenn, Ramesh, Naresh, MacPhee, Daniel J, Plastow, Graham S, Harding, John C S

“…Porcine reproductive and respiratory syndrome virus 2 (PRRSV-2) infection during late gestation substantially lowers fetal viability and survival. In a…”
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Impact of methimazole-induced hypothyroidism on postnatal swine by Fazioli, James C, Mulligan, Margaret K, Ison, Erin K, Pasternak, J Alex

“…Thyroid hormones regulate metabolic rate, nutrient utilization, growth, and development. Swine are susceptible to thyroid suppression in response to disease or…”
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Expression of pattern recognition receptors in porcine uterine epithelial cells in vivo and in culture by Hamonic, Glenn, Pasternak, J. Alex, Forsberg, Nikki M., Käser, Tobias, Wilson, Heather L.

“…•A number of pattern recognition receptors are expressed by porcine uterine epithelial cells.•TLR3 and TLR9 localize to the apical cell membrane and TLR4…”
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Fetal hypoxia and apoptosis following maternal porcine reproductive and respiratory syndrome virus (PRRSV) infection by Malgarin, Carolina M, Moser, Fiona, Pasternak, J Alex, Hamonic, Glenn, Detmer, Susan E, MacPhee, Daniel J, Harding, John C S

“…Mechanisms of fetal death following maternal PRRSV2 infection remain uncharacterized, although hypoxia from umbilical cord lesions and/or placental detachment…”
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Assessment of Immunological Response and Impacts on Fertility Following Intrauterine Vaccination Delivered to Swine in an Artificial Insemination Dose by Hamonic, Glenn, Pasternak, J Alex, Ng, Siew Hon, Fourie, Kezia R, Simko, Olena M, Deluco, Brodie, Wilson, Heather L

“…To protect the health of sows and gilts, significant investments are directed toward the development of vaccines against infectious agents that impact…”
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A Modular, Tn7-Based System for Making Bioluminescent or Fluorescent Salmonella and Escherichia coli Strains by Shivak, Dylan J, MacKenzie, Keith D, Watson, Nikole L, Pasternak, J Alex, Jones, Brian D, Wang, Yejun, DeVinney, Rebekah, Wilson, Heather L, Surette, Michael G, White, Aaron P

“…Our goal was to develop a robust tagging method that can be used to track bacterial strains in vivo To address this challenge, we adapted two existing systems:…”
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Molecular and Physiological Effects on the Small Intestine of Weaner Pigs Following Feeding with Deoxynivalenol-Contaminated Feed by Pasternak, J Alex, Aiyer, Vaishnavi Iyer Aka, Hamonic, Glenn, Beaulieu, A Denise, Columbus, Daniel A, Wilson, Heather L

“…We intended to assess how exposure of piglets to deoxynivalenol (DON)-contaminated feed impacted their growth, immune response and gut development. Piglets…”
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Claudin-4 Undergoes Age-Dependent Change in Cellular Localization on Pig Jejunal Villous Epithelial Cells, Independent of Bacterial Colonization by Wilson, Heather L., Van Kessel, Andrew G., Kent-Dennis, Coral, Pasternak, J. Alex

“…Newborn piglets are immunologically naïve and must receive passive immunity via colostrum within 24 hours to survive. Mechanisms by which the newborn piglet…”
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Recognizing conserved non-canonical localization patterns of toll-like receptors in tissues and across species by Hamonic, Glenn, Pasternak, J. Alex, Wilson, Heather L.

“…Toll-like receptors (TLR) 1, 2, 4, 5 and 6 were originally characterized as exclusively expressed on the cell surface and TLR 3, 7, 8 and 9 were said to be…”
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Compensatory mechanisms in response to induced hypothyroidism in the late gestation pig fetus by Ison, Erin K., Kent-Dennis, Coral E., Fazioli, James, Mulligan, Margaret K., Pham, Audrey, Pasternak, J. Alex

“…To understand the effect of fetal thyroid gland disruption on development in swine, we evaluated thyroid hormone levels, growth and developmental…”
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Pig preovulatory oocytes modulate cumulus cell protein and gene expression in vitro by Paradis, Francois, Moore, Harry S., Pasternak, J. Alex, Novak, Susan, Dyck, Michael K., Dixon, Walter T., Foxcroft, George R.

“…This study investigated the changes in protein and gene expression in oocytectomized cumulus cells (OOX) of medium-sized follicles from gilts, cultured with or…”
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Immunoproteomic analysis of Lawsonia intracellularis identifies candidate neutralizing antibody targets for use in subunit vaccine development by Obradovic, Milan, Pasternak, J. Alex, Hon Ng, Siew, Allan, Brenda, Brownlie, Robert, Wilson, Heather L.

“…•We used proteomic analysis to identify immunogenic Lawsonia intracellularis proteins.•Four immunogenic bacterial proteins predicted to be expressed on the…”
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Effect of porcine reproductive and respiratory syndrome virus 2 on tight junction gene expression at the maternal-fetal interface by Guidoni, Pauline B., Pasternak, J. Alex, Hamonic, Glenn, MacPhee, Daniel J., Harding, John C.S.

“…Understanding why intrauterine growth restricted (IUGR) fetuses are more resilient to transplacental porcine reproductive and respiratory syndrome virus-2…”
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