Search Results - "Pasterkamp, Gerard"

Methods of accelerated atherosclerosis in diabetic patients by Pasterkamp, Gerard

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Low-density lipoproteins cause atherosclerotic cardiovascular disease: pathophysiological, genetic, and therapeutic insights: a consensus statement from the European Atherosclerosis Society Consensus Panel by Borén, Jan, Chapman, M John, Krauss, Ronald M, Packard, Chris J, Bentzon, Jacob F, Binder, Christoph J, Daemen, Mat J, Demer, Linda L, Hegele, Robert A, Nicholls, Stephen J, Nordestgaard, Børge G, Watts, Gerald F, Bruckert, Eric, Fazio, Sergio, Ference, Brian A, Graham, Ian, Horton, Jay D, Landmesser, Ulf, Laufs, Ulrich, Masana, Luis, Pasterkamp, Gerard, Raal, Frederick J, Ray, Kausik K, Schunkert, Heribert, Taskinen, Marja-Riitta, van de Sluis, Bart, Wiklund, Olov, Tokgozoglu, Lale, Catapano, Alberico L, Ginsberg, Henry N

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Microanatomy of the Human Atherosclerotic Plaque by Single-Cell Transcriptomics by Depuydt, Marie A.C., Prange, Koen H.M., Slenders, Lotte, Örd, Tiit, Elbersen, Danny, Boltjes, Arjan, de Jager, Saskia C.A., Asselbergs, Folkert W., de Borst, Gert J., Aavik, Einari, Lönnberg, Tapio, Lutgens, Esther, Glass, Christopher K., den Ruijter, Hester M., Kaikkonen, Minna U., Bot, Ilze, Slütter, Bram, van der Laan, Sander W., Yla-Herttuala, Seppo, Mokry, Michal, Kuiper, Johan, de Winther, Menno P.J., Pasterkamp, Gerard

“…RATIONALE:Atherosclerotic lesions are known for their cellular heterogeneity, yet the molecular complexity within the cells of human plaques has not been fully…”
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Stem Cell Pluripotency Genes Klf4 and Oct4 Regulate Complex SMC Phenotypic Changes Critical in Late-Stage Atherosclerotic Lesion Pathogenesis by Alencar, Gabriel F., Owsiany, Katherine M., Karnewar, Santosh, Sukhavasi, Katyayani, Mocci, Giuseppe, Nguyen, Anh T., Williams, Corey M., Shamsuzzaman, Sohel, Mokry, Michal, Henderson, Christopher A., Haskins, Ryan, Baylis, Richard A., Finn, Aloke V., McNamara, Coleen A., Zunder, Eli R., Venkata, Vamsidhar, Pasterkamp, Gerard, Björkegren, Johan, Bekiranov, Stefan, Owens, Gary K.

“…Rupture and erosion of advanced atherosclerotic lesions with a resultant myocardial infarction or stroke are the leading worldwide cause of death. However, we…”
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Exercise reduces inflammatory cell production and cardiovascular inflammation via instruction of hematopoietic progenitor cells by Frodermann, Vanessa, Rohde, David, Courties, Gabriel, Severe, Nicolas, Schloss, Maximilian J., Amatullah, Hajera, McAlpine, Cameron S., Cremer, Sebastian, Hoyer, Friedrich F., Ji, Fei, van Koeverden, Ian D., Herisson, Fanny, Honold, Lisa, Masson, Gustavo Santos, Zhang, Shuang, Grune, Jana, Iwamoto, Yoshiko, Schmidt, Stephen P., Wojtkiewicz, Gregory R., Lee, I-Hsiu, Gustafsson, Karin, Pasterkamp, Gerard, de Jager, Saskia C. A., Sadreyev, Ruslan I., MacFadyen, Jean, Libby, Peter, Ridker, Paul, Scadden, David T., Naxerova, Kamila, Jeffrey, Kate L., Swirski, Filip K., Nahrendorf, Matthias

“…A sedentary lifestyle, chronic inflammation and leukocytosis increase atherosclerosis; however, it remains unclear whether regular physical activity influences…”
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MicroRNA-100 Suppresses Chronic Vascular Inflammation by Stimulation of Endothelial Autophagy by Pankratz, Franziska, Hohnloser, Catherine, Bemtgen, Xavier, Jaenich, Caterina, Kreuzaler, Sheena, Hoefer, Imo, Pasterkamp, Gerard, Mastroianni, Justin, Zeiser, Robert, Smolka, Christian, Schneider, Laura, Martin, Julien, Juschkat, Maike, Helbing, Thomas, Moser, Martin, Bode, Christoph, Grundmann, Sebastian

“…RATIONALE:The interaction of circulating cells within the vascular wall is a critical event in chronic inflammatory processes, such as atherosclerosis, but the…”
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The transverse aortic constriction heart failure animal model: a systematic review and meta-analysis by Bosch, Lena, de Haan, Judith J., Bastemeijer, Marissa, van der Burg, Jennifer, van der Worp, Erik, Wesseling, Marian, Viola, Margarida, Odille, Clémene, el Azzouzi, Hamid, Pasterkamp, Gerard, Sluijter, Joost P.G., Wever, Kimberley E., de Jager, Saskia C.A.

“…The transverse aortic constriction (TAC) model is frequently used to study adverse cardiac remodeling upon pressure overload. We set out to define the most…”
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Sex-dependent gene co-expression in the human body by Hartman, Robin J. G., Mokry, Michal, Pasterkamp, Gerard, den Ruijter, Hester M.

“…Many pathophysiological mechanisms in human health and disease are dependent on sex. Systems biology approaches are successfully used to decipher human disease…”
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B Cell–Activating Factor Neutralization Aggravates Atherosclerosis by Tsiantoulas, Dimitrios, Sage, Andrew P, Göderle, Laura, Ozsvar-Kozma, Maria, Murphy, Deirdre, Porsch, Florentina, Pasterkamp, Gerard, Menche, Jörg, Schneider, Pascal, Mallat, Ziad, Binder, Christoph J

“…BACKGROUND:Atherosclerotic cardiovascular disease (heart attacks and strokes) is the major cause of death globally and is caused by the buildup of a plaque in…”
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Ceramides and phospholipids in plasma extracellular vesicles are associated with high risk of major cardiovascular events after carotid endarterectomy by Timmerman, Nathalie, Waissi, Farahnaz, Dekker, Mirthe, de Borst, Gert J., van Bennekom, Joelle, de Winter, Robbert J., Hilvo, Mika, Jylhä, Antti, Pasterkamp, Gerard, de Kleijn, Dominique P. V., Laaksonen, Reijo

“…Ceramides and phosphatidylcholines (PCs) are bioactive lipids and lipid bilayer membrane components. Distinct ceramides/PCs (ratios) predict cardiovascular…”
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Plasmin is a natural trigger for bradykinin production in patients with hereditary angioedema with factor XII mutations by de Maat, Steven, MSc, Björkqvist, Jenny, PhD, Suffritti, Chiara, PhD, Wiesenekker, Chantal P., MSc, Nagtegaal, Willem, Koekman, Arnold, BSc, van Dooremalen, Sanne, BSc, Pasterkamp, Gerard, PhD, de Groot, Philip G., PhD, Cicardi, Marco, PhD, Renné, Thomas, PhD, Maas, Coen, PhD

“…Background Patients with angioedema experience unpredictable attacks of tissue swelling in which bradykinin is implicated. Several distinct mutations in Factor…”
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Intrinsic transcriptomic sex differences in human endothelial cells at birth and in adults are associated with coronary artery disease targets by Hartman, Robin J. G., Kapteijn, Daniek M. C., Haitjema, Saskia, Bekker, Mireille N., Mokry, Michal, Pasterkamp, Gerard, Civelek, Mete, den Ruijter, Hester M.

“…Sex differences in endothelial cell (EC) biology may reflect intrinsic differences driven by chromosomes or sex steroid exposure and gender differences…”
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Genetic Regulation of Atherosclerosis-Relevant Phenotypes in Human Vascular Smooth Muscle Cells by Aherrahrou, Redouane, Guo, Liang, Nagraj, V. Peter, Aguhob, Aaron, Hinkle, Jameson, Chen, Lisa, Yuhl Soh, Joon, Lue, Dillon, Alencar, Gabriel F., Boltjes, Arjan, van der Laan, Sander W., Farber, Emily, Fuller, Daniela, Anane-Wae, Rita, Akingbesote, Ngozi, Manichaikul, Ani W., Ma, Lijiang, Kaikkonen, Minna U., Björkegren, Johan L.M., Önengüt-Gümüşcü, Suna, Pasterkamp, Gerard, Miller, Clint L., Owens, Gary K., Finn, Aloke, Navab, Mohamad, Fogelman, Alan M., Berliner, Judith A., Civelek, Mete

“…RATIONALE:Coronary artery disease (CAD) is a major cause of morbidity and mortality worldwide. Recent genome-wide association studies revealed 163 loci…”
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Protective role of chaperone-mediated autophagy against atherosclerosis by Madrigal-Matute, Julio, de Bruijn, Jenny, van Kuijk, Kim, Riascos-Bernal, Dario F, Diaz, Antonio, Tasset, Inmaculada, Martín-Segura, Adrián, Gijbels, Marion J J, Sander, Bianca, Kaushik, Susmita, Biessen, Erik A L, Tiano, Simoni, Bourdenx, Mathieu, Krause, Gregory J, McCracken, Ian, Baker, Andrew H, Jin, Han, Sibinga, Nicholas E S, Bravo-Cordero, Jose Javier, Macian, Fernando, Singh, Rajat, Rensen, Patrick C N, Berbée, Jimmy F P, Pasterkamp, Gerard, Sluimer, Judith C, Cuervo, Ana Maria

“…Chaperone-mediated autophagy (CMA) contributes to regulation of energy homeostasis by timely degradation of enzymes involved in glucose and lipid metabolism…”
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High levels of osteoprotegerin are associated with coronary artery calcification in patients suspected of a chronic coronary syndrome by Dekker, Mirthe, Waissi, Farahnaz, Silvis, Max J. M., Bennekom, Joelle V., Schoneveld, Arjan H., de Winter, Robbert J., Isgum, Ivana, Lessmann, Nikolas, Velthuis, Birgitta K., Pasterkamp, Gerard, Mosterd, Arend, Timmers, Leo, de Kleijn, Dominique P. V.

“…Plasma osteoprotegerin (OPG) and vascular smooth muscle cell (VSMC) derived extracellular vesicles (EVs) are important regulators in the process of vascular…”
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Plasma extracellular vesicle proteins are associated with stress-induced myocardial ischemia in women presenting with chest pain by Dekker, Mirthe, Waissi, Farahnaz, van Bennekom, Joelle, Silvis, Max J. M., Timmerman, Nathalie, Bank, Ingrid E. M., Walter, Joan E., Mueller, Christian, Schoneveld, A. H., Schiffelers, Raymond M., Pasterkamp, Gerard, Grobbee, Diederick E., de Winter, Robbert J., Mosterd, A., de Kleijn, Dominique P. V., Timmers, Leo

“…Diagnosing stable ischemic heart disease (IHD) is challenging, especially in females. Currently, no blood test is available. Plasma extracellular vesicles (EV)…”
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Myocardial Ischemia/Reperfusion Injury Is Mediated by Leukocytic Toll-Like Receptor-2 and Reduced by Systemic Administration of a Novel Anti-Toll-Like Receptor-2 Antibody by ARSLAN, Fatih, SMEETS, Mirjam B, DE KLEIJN, Dominique P. V, O'NEILL, Luke A. J, KEOGH, Brian, MCGUIRK, Peter, TIMMERS, Leo, TERSTEEG, Claudia, HOEFER, Imo E, DOEVENDANS, Pieter A, PASTERKAMP, Gerard

“…Reperfusion therapy for myocardial infarction is hampered by detrimental inflammatory responses partly via Toll-like receptor (TLR) activation. Targeting TLR…”
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Reassessing the Mechanisms of Acute Coronary Syndromes by Libby, Peter, Pasterkamp, Gerard, Crea, Filippo, Jang, Ik-Kyung

“…The mechanisms that underlie superficial erosion, a cause of coronary thrombosis distinct from plaque rupture, have garnered recent interest. In an era of…”
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AG-348 (Mitapivat), an allosteric activator of red blood cell pyruvate kinase, increases enzymatic activity, protein stability, and ATP levels over a broad range of PKLR genotypes by Rab, Minke A E, Van Oirschot, Brigitte A, Kosinski, Penelope A, Hixon, Jeffrey, Johnson, Kendall, Chubukov, Victor, Dang, Lenny, Pasterkamp, Gerard, Van Straaten, Stephanie, Van Solinge, Wouter W, Van Beers, Eduard J, Kung, Charles, Van Wijk, Richard

“…Pyruvate kinase (PK) deficiency is a rare hereditary disorder affecting red cell (RBC) glycolysis, causing changes in metabolism including a deficiency in ATP…”
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MicroRNA-100 Regulates Neovascularization by Suppression of Mammalian Target of Rapamycin in Endothelial and Vascular Smooth Muscle Cells by GRUNDMANN, Sebastian, HANS, Felix P, MOSER, Martin, KINNIRY, Sheena, HEINKE, Jennifer, HELBING, Thomas, BLUHM, Franziska, SLUIJTER, Joost P. G, HOEFER, Imo, PASTERKAMP, Gerard, BODE, Christoph

“…The adaptive growth of blood vessels is an important protective mechanism in cardiovascular disease. However, the underlying regulatory mechanisms of this…”
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