Search Results - "Passos, João F"

Mitochondrial dysfunction and cell senescence: deciphering a complex relationship by Chapman, James, Fielder, Edward, Passos, João F.

“…Cellular senescence and mitochondrial dysfunction have both been defined as classical hallmarks of the ageing process. Here, we review the intricate…”
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Cellular senescence: all roads lead to mitochondria by Martini, Hélène, Passos, João F.

“…Senescence is a multi‐functional cell fate, characterized by an irreversible cell‐cycle arrest and a pro‐inflammatory phenotype, commonly known as the…”
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Telomeres and Cell Senescence - Size Matters Not by Victorelli, Stella, Passos, João F.

“…Telomeres are protective structures present at the ends of linear chromosomes that are important in preventing genome instability. Telomeres shorten as a…”
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Expansion and Cell-Cycle Arrest: Common Denominators of Cellular Senescence by Ogrodnik, Mikolaj, Salmonowicz, Hanna, Jurk, Diana, Passos, João F.

“…Cellular senescence is a major driver of age-related diseases, and senotherapies are being tested in clinical trials. Despite its popularity, cellular…”
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Cellular senescence mediates fibrotic pulmonary disease by Schafer, Marissa J., White, Thomas A., Iijima, Koji, Haak, Andrew J., Ligresti, Giovanni, Atkinson, Elizabeth J., Oberg, Ann L., Birch, Jodie, Salmonowicz, Hanna, Zhu, Yi, Mazula, Daniel L., Brooks, Robert W., Fuhrmann-Stroissnigg, Heike, Pirtskhalava, Tamar, Prakash, Y. S., Tchkonia, Tamara, Robbins, Paul D., Aubry, Marie Christine, Passos, João F., Kirkland, James L., Tschumperlin, Daniel J., Kita, Hirohito, LeBrasseur, Nathan K.

“…Idiopathic pulmonary fibrosis (IPF) is a fatal disease characterized by interstitial remodelling, leading to compromised lung function. Cellular senescence…”
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Telomere dysfunction in ageing and age-related diseases by Rossiello, Francesca, Jurk, Diana, Passos, João F., d’Adda di Fagagna, Fabrizio

“…Ageing organisms accumulate senescent cells that are thought to contribute to body dysfunction. Telomere shortening and damage are recognized causes of…”
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Stress, cell senescence and organismal ageing by de Magalhães, João Pedro, Passos, João F.

“…•Cellular senescence is the irreversible arrest of normally dividing cells.•Telomere shortening is the mechanism driving senescence in human…”
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On the evolution of cellular senescence by Kowald, Axel, Passos, João F., Kirkwood, Thomas B. L.

“…The idea that senescent cells are causally involved in aging has gained strong support from findings that the removal of such cells alleviates many age‐related…”
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Mitochondria and cellular senescence: Implications for musculoskeletal ageing by Habiballa, Leena, Salmonowicz, Hanna, Passos, João F.

“…Musculoskeletal ageing and its associated diseases are major contributors to the loss of independence and reduced quality of life in older people. Several…”
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Mitochondria: Are they causal players in cellular senescence? by Correia-Melo, Clara, Passos, João F.

“…Cellular senescence entails an irreversible cell-cycle arrest characterised by drastic cytomorphological and metabolic changes. In recent years, the…”
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Senolytic Drugs: Reducing Senescent Cell Viability to Extend Health Span by Robbins, Paul D, Jurk, Diana, Khosla, Sundeep, Kirkland, James L, LeBrasseur, Nathan K, Miller, Jordan D, Passos, João F, Pignolo, Robert J, Tchkonia, Tamar, Niedernhofer, Laura J

“…Senescence is the consequence of a signaling mechanism activated in stressed cells to prevent proliferation of cells with damage. Senescent cells (Sncs) often…”
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A new gene set identifies senescent cells and predicts senescence-associated pathways across tissues by Saul, Dominik, Kosinsky, Robyn Laura, Atkinson, Elizabeth J., Doolittle, Madison L., Zhang, Xu, LeBrasseur, Nathan K., Pignolo, Robert J., Robbins, Paul D., Niedernhofer, Laura J., Ikeno, Yuji, Jurk, Diana, Passos, João F., Hickson, LaTonya J., Xue, Ailing, Monroe, David G., Tchkonia, Tamara, Kirkland, James L., Farr, Joshua N., Khosla, Sundeep

“…Although cellular senescence drives multiple age-related co-morbidities through the senescence-associated secretory phenotype, in vivo senescent cell…”
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Reducing Senescent Cell Burden in Aging and Disease by Pignolo, Robert J., Passos, João F., Khosla, Sundeep, Tchkonia, Tamara, Kirkland, James L.

“…Cellular senescence is a primary aging process and tumor suppressive mechanism characterized by irreversible growth arrest, apoptosis resistance, production of…”
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Cytoplasmic DNA: sources, sensing, and role in aging and disease by Miller, Karl N., Victorelli, Stella G., Salmonowicz, Hanna, Dasgupta, Nirmalya, Liu, Tianhui, Passos, João F., Adams, Peter D.

“…Endogenous cytoplasmic DNA (cytoDNA) species are emerging as key mediators of inflammation in diverse physiological and pathological contexts. Although the…”
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Pharmacological clearance of senescent cells improves survival and recovery in aged mice following acute myocardial infarction by Walaszczyk, Anna, Dookun, Emily, Redgrave, Rachael, Tual‐Chalot, Simon, Victorelli, Stella, Spyridopoulos, Ioakim, Owens, Andrew, Arthur, Helen M., Passos, João F., Richardson, Gavin D.

“…Cardiovascular disease is the leading cause of death in individuals over 60 years old. Aging is associated with an increased prevalence of coronary artery…”
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Cellular senescence drives age-dependent hepatic steatosis by Ogrodnik, Mikolaj, Miwa, Satomi, Tchkonia, Tamar, Tiniakos, Dina, Wilson, Caroline L., Lahat, Albert, Day, Christoper P., Burt, Alastair, Palmer, Allyson, Anstee, Quentin M., Grellscheid, Sushma Nagaraja, Hoeijmakers, Jan H J., Barnhoorn, Sander, Mann, Derek A., Bird, Thomas G., Vermeij, Wilbert P., Kirkland, James L., Passos, João F., von Zglinicki, Thomas, Jurk, Diana

“…The incidence of non-alcoholic fatty liver disease (NAFLD) increases with age. Cellular senescence refers to a state of irreversible cell-cycle arrest combined…”
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Cellular Senescence: Defining a Path Forward by Gorgoulis, Vassilis, Adams, Peter D., Alimonti, Andrea, Bennett, Dorothy C., Bischof, Oliver, Bishop, Cleo, Campisi, Judith, Collado, Manuel, Evangelou, Konstantinos, Ferbeyre, Gerardo, Gil, Jesús, Hara, Eiji, Krizhanovsky, Valery, Jurk, Diana, Maier, Andrea B., Narita, Masashi, Niedernhofer, Laura, Passos, João F., Robbins, Paul D., Schmitt, Clemens A., Sedivy, John, Vougas, Konstantinos, von Zglinicki, Thomas, Zhou, Daohong, Serrano, Manuel, Demaria, Marco

“…Cellular senescence is a cell state implicated in various physiological processes and a wide spectrum of age-related diseases. Recently, interest in…”
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Senescent cells evade immune clearance via HLA-E-mediated NK and CD8+ T cell inhibition by Pereira, Branca I., Devine, Oliver P., Vukmanovic-Stejic, Milica, Chambers, Emma S., Subramanian, Priya, Patel, Neil, Virasami, Alex, Sebire, Neil J., Kinsler, Veronica, Valdovinos, Alexis, LeSaux, Claude Jourdan, Passos, João F., Antoniou, Antony, Rustin, Malcom H. A., Campisi, Judith, Akbar, Arne N.

“…Senescent cells accumulate in human tissues during ageing and contribute to age-related pathologies. The mechanisms responsible for their accumulation are…”
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Mitochondrial inner membrane permeabilisation enables mtDNA release during apoptosis by Riley, Joel S, Quarato, Giovanni, Cloix, Catherine, Lopez, Jonathan, O'Prey, Jim, Pearson, Matthew, Chapman, James, Sesaki, Hiromi, Carlin, Leo M, Passos, João F, Wheeler, Ann P, Oberst, Andrew, Ryan, Kevin M, Tait, Stephen WG

“…During apoptosis, pro‐apoptotic BAX and BAK are activated, causing mitochondrial outer membrane permeabilisation (MOMP), caspase activation and cell death…”
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Mitochondria-to-nucleus retrograde signaling drives formation of cytoplasmic chromatin and inflammation in senescence by Vizioli, Maria Grazia, Liu, Tianhui, Miller, Karl N, Robertson, Neil A, Gilroy, Kathryn, Lagnado, Anthony B, Perez-Garcia, Arantxa, Kiourtis, Christos, Dasgupta, Nirmalya, Lei, Xue, Kruger, Patrick J, Nixon, Colin, Clark, William, Jurk, Diana, Bird, Thomas G, Passos, João F, Berger, Shelley L, Dou, Zhixun, Adams, Peter D

“…Cellular senescence is a potent tumor suppressor mechanism but also contributes to aging and aging-related diseases. Senescence is characterized by a stable…”
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