Search Results - "Passarelli, Melissa K"

Peptide Fragmentation and Surface Structural Analysis by Means of ToF-SIMS Using Large Cluster Ion Sources by Yokoyama, Yuta, Aoyagi, Satoka, Fujii, Makiko, Matsuo, Jiro, Fletcher, John S, Lockyer, Nicholas P, Vickerman, John C, Passarelli, Melissa K, Havelund, Rasmus, Seah, Martin P

“…Peptide or protein structural analysis is crucial for the evaluation of biochips and biodevices, therefore an analytical technique with the ability to detect…”
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Lipid imaging with time-of-flight secondary ion mass spectrometry (ToF-SIMS) by Passarelli, Melissa K., Winograd, Nicholas

“…Fundamental advances in secondary ion mass spectrometry (SIMS) now allow for the examination and characterization of lipids directly from biological materials…”
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The 3D OrbiSIMS—label-free metabolic imaging with subcellular lateral resolution and high mass-resolving power by Passarelli, Melissa K, Pirkl, Alexander, Moellers, Rudolf, Grinfeld, Dmitry, Kollmer, Felix, Havelund, Rasmus, Newman, Carla F, Marshall, Peter S, Arlinghaus, Henrik, Alexander, Morgan R, West, Andy, Horning, Stevan, Niehuis, Ewald, Makarov, Alexander, Dollery, Colin T, Gilmore, Ian S

“…The high spatial resolution of secondary ion mass spectrometry and the high resolving power of the Orbitrap mass spectrometer are combined in a single imaging…”
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Single-cell imaging mass spectrometry by Passarelli, Melissa K, Ewing, Andrew G

“…•SIMS is the predominant imaging mass spectrometry (IMS) technique for single-cell MS imaging.•SIMS at subcellular spatial resolution has led to new biological…”
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C60-SIMS studies of glycerophospholipid in a LIPID MAPS model system: KDO2-Lipid A stimulated RAW 264.7 cells by Passarelli, Melissa K., Ewing, Andrew G., Winograd, Nicholas

“…Although secondary ion mass spectrometry (SIMS) has been successfully employed for mapping lipid distributions at the cellular level, the identification of…”
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Chemical intervention in plant sugar signalling increases yield and resilience by Griffiths, Cara A., Sagar, Ram, Geng, Yiqun, Primavesi, Lucia F., Patel, Mitul K., Passarelli, Melissa K., Gilmore, Ian S., Steven, Rory T., Bunch, Josephine, Paul, Matthew J., Davis, Benjamin G.

“…Treatment with signalling precursors of trehalose-6-phosphate allows light-triggered release of trehalose-6-phosphate in Arabidopsis thaliana and increases the…”
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Single-Cell Analysis: Visualizing Pharmaceutical and Metabolite Uptake in Cells with Label-Free 3D Mass Spectrometry Imaging by Passarelli, Melissa K, Newman, Carla F, Marshall, Peter S, West, Andrew, Gilmore, Ian S, Bunch, Josephine, Alexander, Morgan R, Dollery, Colin T

“…Detecting metabolites and parent compound within a cell type is now a priority for pharmaceutical development. In this context, three-dimensional secondary ion…”
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Chemical Analysis of Single Cells by Trouillon, Raphaël, Passarelli, Melissa K, Wang, Jun, Kurczy, Michael E, Ewing, Andrew G

“…In this Review, we provide an overview of methods developed for chemical analysis of single cells over the last two years. Many biological systems contain an…”
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Electrospun collagen-based nanofibres: A sustainable material for improved antibiotic utilisation in tissue engineering applications by Hall Barrientos, Ivan J., Paladino, Eleonora, Szabó, Peter, Brozio, Sarah, Hall, Peter J., Oseghale, Charles I., Passarelli, Melissa K., Moug, Susan J., Black, Richard A., Wilson, Clive G., Zelkó, Romana, Lamprou, Dimitrios A.

“…[Display omitted] For the creation of scaffolds in tissue engineering applications, it is essential to control the physical morphology of fibres and to choose…”
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Single-Cell Lipidomics: Characterizing and Imaging Lipids on the Surface of Individual Aplysia californica Neurons with Cluster Secondary Ion Mass Spectrometry by Passarelli, Melissa K, Ewing, Andrew G, Winograd, Nicholas

“…Neurons isolated from Aplysia californica, an organism with a well-defined neural network, were imaged with secondary ion mass spectrometry, C60-SIMS. A major…”
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Dibromocarbene Functionalization of Boron Nitride Nanosheets: Toward Band Gap Manipulation and Nanocomposite Applications by Sainsbury, Toby, O’Neill, Arlene, Passarelli, Melissa K, Seraffon, Maud, Gohil, Dipak, Gnaniah, Sam, Spencer, Steve J, Rae, Alasdair, Coleman, Jonathan N

“…We report the covalent functionalization of exfoliated boron nitride nanosheets (BNNSs) using dibromocarbene (DBC) species. The functionalization of BNNSs is…”
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Fabrication and characterisation of drug-loaded electrospun polymeric nanofibers for controlled release in hernia repair by Hall Barrientos, Ivan J., Paladino, Eleonora, Brozio, Sarah, Passarelli, Melissa K., Moug, Susan, Black, Richard A., Wilson, Clive G., Lamprou, Dimitrios A.

“…[Display omitted] The chemical distribution and mechanical effects of drug compounds in loaded electrospun scaffolds, a potential material for hernia repair…”
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OrbiSIMS Imaging Identifies Molecular Constituents of the Perialgal Vacuole Membrane of Paramecium bursaria with Symbiotic Chlorella variabilis by Aoyagi, Satoka, Kodama, Yuuki, Passarelli, Melissa K, Vorng, Jean-Luc, Kawashima, Tomoko, Yoshikiyo, Keisuke, Yamamoto, Tatsuyuki, Gilmore, Ian S

“…The protist (mostly single-celled organisms), Paramecium bursaria, forms an intracellular symbiotic relationship with the single-celled algae, Chlorella…”
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Correlative Hyperspectral Imaging Using a Dimensionality-Reduction-Based Image Fusion Method by Race, Alan M, Rae, Alasdair, Vorng, Jean-Luc, Havelund, Rasmus, Dexter, Alex, Kumar, Naresh, Steven, Rory T, Passarelli, Melissa K, Tyler, Bonnie J, Bunch, Josephine, Gilmore, Ian S

“…Chemical imaging techniques are increasingly being used in combination to achieve a greater understanding of a sample. This is especially true in the case of…”
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Intracellular Drug UptakeA Comparison of Single Cell Measurements Using ToF-SIMS Imaging and Quantification from Cell Populations with LC/MS/MS by Newman, Carla F, Havelund, Rasmus, Passarelli, Melissa K, Marshall, Peter S, Francis, Ian, West, Andy, Alexander, Morgan R, Gilmore, Ian S, Dollery, Colin T

“…ToF-SIMS is a label-free imaging method that has been shown to enable imaging of amiodarone in single rat macrophage (NR8383) cells. In this study, we show…”
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Development of an Organic Lateral Resolution Test Device for Imaging Mass Spectrometry by Passarelli, Melissa K, Wang, Jun, Mohammadi, Amir Saeid, Trouillon, Raphaël, Gilmore, Ian, Ewing, Andrew G

“…An organic lateral resolution test device has been developed to measure the performance of imaging mass spectrometry (IMS) systems. The device contains…”
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Following spatial Aβ aggregation dynamics in evolving Alzheimer's disease pathology by imaging stable isotope labeling kinetics by Michno, Wojciech, Stringer, Katie M, Enzlein, Thomas, Passarelli, Melissa K, Escrig, Stephane, Vitanova, Karina, Wood, Jack, Blennow, Kaj, Zetterberg, Henrik, Meibom, Anders, Hopf, Carsten, Edwards, Frances A, Hanrieder, Jörg

“…β-Amyloid (Aβ) plaque formation is the major pathological hallmark of Alzheimer's disease (AD) and constitutes a potentially critical, early inducer driving AD…”
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Semiempirical Rules To Determine Drug Sensitivity and Ionization Efficiency in Secondary Ion Mass Spectrometry Using a Model Tissue Sample by Vorng, Jean-Luc, Kotowska, Anna M, Passarelli, Melissa K, West, Andrew, Marshall, Peter S, Havelund, Rasmus, Seah, Martin P, Dollery, Colin T, Rakowska, Paulina D, Gilmore, Ian S

“…There is an increasing need in the pharmaceutical industry to reduce drug failure at late stage and thus reduce the cost of developing a new medicine. Since…”
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Single Cell Lipidomics: Characterizing and Imaging Lipids on the Surface of Individual Aplysia Californica Neurons with Cluster SIMS by Passarelli, Melissa K., Ewing, Andrew G., Winograd, Nicholas

“…Neurons isolated from Aplysia californica , an organism with a well-defined neural network, were imaged with secondary ion mass spectrometry, C 60 -SIMS. A…”
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C(60)-SIMS Studies of Glycerophospholipid in a LIPID MAPS Model System: KDO(2)-Lipid A Stimulated RAW 264.7 Cells by Passarelli, Melissa K, Ewing, Andrew G, Winograd, Nicholas

“…Although secondary ion mass spectrometry (SIMS) has been successfully employed for mapping lipid distributions at the cellular level, the identification of…”
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