Search Results - "Pasquevich, Karina"

Safety and immunogenicity of a SARS-CoV-2 Gamma variant RBD-based protein adjuvanted vaccine used as booster in healthy adults by Pasquevich, Karina A., Coria, Lorena M., Ceballos, Ana, Mazzitelli, Bianca, Rodriguez, Juan Manuel, Demaría, Agostina, Pueblas Castro, Celeste, Bruno, Laura, Saposnik, Lucas, Salvatori, Melina, Varese, Augusto, González, Soledad, González Martínez, Veronica V., Geffner, Jorge, Álvarez, Diego, Feleder, Ethel, Halabe, Karina, Perez Lera, Pablo E., de Oca, Federico Montes, Vega, Julio C., Lombardo, Mónica, Yerino, Gustavo A., Fló, Juan, Cassataro, Juliana

“…A Gamma Variant RBD-based aluminum hydroxide adjuvanted vaccine called ARVAC CG was selected for a first in human clinical trial. Healthy male and female…”
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Systemic bacterial infections affect dendritic cell development and function by Bieber, Kristin, Günter, Manina, Pasquevich, Karina A., Autenrieth, Stella E.

“…Dendritic cells (DCs) are critical in host defense against infection. DC depletion is an early event in the course of sepsis that may impair the host defense…”
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An oral vaccine based on U-Omp19 induces protection against B. abortus mucosal challenge by inducing an adaptive IL-17 immune response in mice by Pasquevich, Karina A, Ibañez, Andrés E, Coria, Lorena M, García Samartino, Clara, Estein, Silvia M, Zwerdling, Astrid, Barrionuevo, Paula, Oliveira, Fernanda S, Seither, Christine, Warzecha, Heribert, Oliveira, Sergio C, Giambartolomei, Guillermo H, Cassataro, Juliana

“…As Brucella infections occur mainly through mucosal surfaces, the development of mucosal administered vaccines could be radical for the control of brucellosis…”
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U-Omp19 from Brucella abortus increases dmLT immunogenicity and improves protection against Escherichia coli heat-labile toxin (LT) oral challenge by Coria, Lorena M., Martinez, Franco L., Bruno, Laura A., Pasquevich, Karina A., Cassataro, Juliana

“…•Oral co-administration of dmLT with U-Omp19 increases dmLT immunogenicity.•U-Omp19 oral co-delivery with dmLT induces anti-LT antibody responses.•U-Omp19…”
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A Gamma-adapted subunit vaccine induces broadly neutralizing antibodies against SARS-CoV-2 variants and protects mice from infection by Coria, Lorena M., Rodriguez, Juan Manuel, Demaria, Agostina, Bruno, Laura A., Medrano, Mayra Rios, Castro, Celeste Pueblas, Castro, Eliana F., Del Priore, Sabrina A., Hernando Insua, Andres C., Kaufmann, Ingrid G., Saposnik, Lucas M., Stone, William B., Prado, Lineia, Notaro, Ulises S., Amweg, Ayelen N., Diaz, Pablo U., Avaro, Martin, Ortega, Hugo, Ceballos, Ana, Krum, Valeria, Zurvarra, Francisco M., Sidabra, Johanna E., Drehe, Ignacio, Baqué, Jonathan A., Li Causi, Mariana, De Nichilo, Analia V., Payes, Cristian J., Southard, Teresa, Vega, Julio C., Auguste, Albert J., Álvarez, Diego E., Flo, Juan M., Pasquevich, Karina A., Cassataro, Juliana

“…In the context of continuous emergence of SARS-CoV-2 variants of concern (VOCs), one strategy to prevent the severe outcomes of COVID-19 is developing safe and…”
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Oral co-administration of a bacterial protease inhibitor in the vaccine formulation increases antigen delivery at the intestinal epithelial barrier by Coria, Lorena M., Risso, Gabriela S., Guaimas, Francisco F., Ferrero, Mariana C., Bruno, Laura, Pasquevich, Karina A., Cassataro, Juliana

“…The study of capture and processing of antigens (Ags) by intestinal epithelial cells is very important for development of new oral administration systems…”
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A Novel Bacterial Protease Inhibitor Adjuvant in RBD-Based COVID-19 Vaccine Formulations Containing Alum Increases Neutralizing Antibodies, Specific Germinal Center B Cells and Confers Protection Against SARS-CoV-2 Infection in Mice by Coria, Lorena M, Saposnik, Lucas M, Pueblas Castro, Celeste, Castro, Eliana F, Bruno, Laura A, Stone, William B, Pérez, Paula S, Darriba, Maria Laura, Chemes, Lucia B, Alcain, Julieta, Mazzitelli, Ignacio, Varese, Augusto, Salvatori, Melina, Auguste, Albert J, Álvarez, Diego E, Pasquevich, Karina A, Cassataro, Juliana

“…In this work, we evaluated recombinant receptor binding domain (RBD)-based vaccine formulation prototypes with potential for further clinical development. We…”
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Immunization with Recombinant Brucella Species Outer Membrane Protein Omp16 or Omp19 in Adjuvant Induces Specific CD4⁺ and CD8⁺ T Cells as Well as Systemic and Oral Protection against Brucella abortus Infection by Pasquevich, Karina A, Estein, Silvia M, Samartino, Clara García, Zwerdling, Astrid, Coria, Lorena M, Barrionuevo, Paula, Fossati, Carlos A, Giambartolomei, Guillermo H, Cassataro, Juliana

“…Available vaccines against Brucella spp. are live attenuated Brucella strains. In order to engineer a better vaccine to be used in animals and humans, our…”
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Depletion of dendritic cells enhances innate anti-bacterial host defense through modulation of phagocyte homeostasis by Autenrieth, Stella E, Warnke, Philipp, Wabnitz, Guido H, Lucero Estrada, Cecilia, Pasquevich, Karina A, Drechsler, Doreen, Günter, Manina, Hochweller, Kristin, Novakovic, Ana, Beer-Hammer, Sandra, Samstag, Yvonne, Hämmerling, Günter J, Garbi, Natalio, Autenrieth, Ingo B

“…Dendritic cells (DCs) as professional antigen-presenting cells play an important role in the initiation and modulation of the adaptive immune response…”
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Omp19 Enables Brucella abortus to Evade the Antimicrobial Activity From Host's Proteolytic Defense System by Pasquevich, Karina A, Carabajal, Marianela V, Guaimas, Francisco F, Bruno, Laura, Roset, Mara S, Coria, Lorena M, Rey Serrantes, Diego A, Comerci, Diego J, Cassataro, Juliana

“…Pathogenic microorganisms confront several proteolytic events in the molecular interplay with their host, highlighting that proteolysis and its regulation play…”
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A Brucella spp. Protease Inhibitor Limits Antigen Lysosomal Proteolysis, Increases Cross-Presentation, and Enhances CD8+ T Cell Responses by Coria, Lorena M, Ibañez, Andrés E, Tkach, Mercedes, Sabbione, Florencia, Bruno, Laura, Carabajal, Marianela V, Berguer, Paula M, Barrionuevo, Paula, Schillaci, Roxana, Trevani, Analía S, Giambartolomei, Guillermo H, Pasquevich, Karina A, Cassataro, Juliana

“…In this study, we demonstrate that the unlipidated (U) outer membrane protein (Omp) 19 from Brucella spp. is a competitive inhibitor of human cathepsin L…”
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RomA, A Periplasmic Protein Involved in the Synthesis of the Lipopolysaccharide, Tunes Down the Inflammatory Response Triggered by Brucella by Valguarnera, Ezequiel, Spera, Juan M, Czibener, Cecilia, Fulgenzi, Fabiana R, Casabuono, Adriana C, Altabe, Silvia G, Pasquevich, Karina A, Guaimas, Francisco, Cassataro, Juliana, Couto, Alicia S, Ugalde, Juan E

“…Abstract Brucellaceae are stealthy pathogens with the ability to survive and replicate in the host in the context of a strong immune response. This capacity…”
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Unlipidated outer membrane protein Omp16 (U-Omp16) from Brucella spp. as nasal adjuvant induces a Th1 immune response and modulates the Th2 allergic response to cow's milk proteins by Ibañez, Andrés E, Smaldini, Paola, Coria, Lorena M, Delpino, María V, Pacífico, Lucila G G, Oliveira, Sergio C, Risso, Gabriela S, Pasquevich, Karina A, Fossati, Carlos Alberto, Giambartolomei, Guillermo H, Docena, Guillermo H, Cassataro, Juliana

“…The discovery of novel mucosal adjuvants will help to develop new formulations to control infectious and allergic diseases. In this work we demonstrate that…”
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Innate immune system favors emergency monopoiesis at the expense of DC‐differentiation to control systemic bacterial infection in mice by Pasquevich, Karina A., Bieber, Kristin, Günter, Manina, Grauer, Matthias, Pötz, Oliver, Schleicher, Ulrike, Biedermann, Tilo, Beer‐Hammer, Sandra, Bühring, Hans‐Jörg, Rammensee, Hans‐Georg, Zender, Lars, Autenrieth, Ingo B., Lengerke, Claudia, Autenrieth, Stella E.

“…DCs are professional APCs playing a crucial role in the initiation of T‐cell responses to combat infection. However, systemic bacterial infection with various…”
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The protein moiety of Brucella abortus outer membrane protein 16 is a new bacterial pathogen-associated molecular pattern that activates dendritic cells in vivo, induces a Th1 immune response, and is a promising self-adjuvanting vaccine against systemic and oral acquired brucellosis by Pasquevich, Karina A, García Samartino, Clara, Coria, Lorena M, Estein, Silvia M, Zwerdling, Astrid, Ibañez, Andrés E, Barrionuevo, Paula, Oliveira, Fernanda Souza de, Carvalho, Natalia Barbosa, Borkowski, Julia, Oliveira, Sergio Costa, Warzecha, Heribert, Giambartolomei, Guillermo H, Cassataro, Juliana

“…Knowing the inherent stimulatory properties of the lipid moiety of bacterial lipoproteins, we first hypothesized that Brucella abortus outer membrane protein…”
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U-Omp19 from Brucella abortus Is a Useful Adjuvant for Vaccine Formulations against Salmonella Infection in Mice by Risso, Gabriela S, Carabajal, Marianela V, Bruno, Laura A, Ibañez, Andrés E, Coria, Lorena M, Pasquevich, Karina A, Lee, Seung-Joo, McSorley, Stephen J, Briones, Gabriel, Cassataro, Juliana

“…Most pathogens infect through mucosal surfaces, and parenteral immunization typically fails to induce effective immune responses at these sites. Development of…”
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A bacterial protease inhibitor protects antigens delivered in oral vaccines from digestion while triggering specific mucosal immune responses by Ibañez, Andrés Esteban, Coria, Lorena Mirta, Carabajal, Marianela Verónica, Delpino, María Victoria, Risso, Gabriela Sofía, Cobiello, Paula Gonzalez, Rinaldi, Jimena, Barrionuevo, Paula, Bruno, Laura, Frank, Fernanda, Klinke, Sebastián, Goldbaum, Fernando Alberto, Briones, Gabriel, Giambartolomei, Guillermo Hernán, Pasquevich, Karina Alejandra, Cassataro, Juliana

“…We report here that a bacterial protease inhibitor from Brucella spp. called U-Omp19 behaves as an ideal constituent for a vaccine formulation against…”
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Brucella abortus Induces the Secretion of Proinflammatory Mediators from Glial Cells Leading to Astrocyte Apoptosis by García Samartino, Clara, Delpino, M. Victoria, Pott Godoy, Clara, Di Genaro, María Silvia, Pasquevich, Karina A, Zwerdling, Astrid, Barrionuevo, Paula, Mathieu, Patricia, Cassataro, Juliana, Pitossi, Fernando, Giambartolomei, Guillermo H

“…Central nervous system (CNS) invasion by bacteria of the genus Brucella results in an inflammatory disorder called neurobrucellosis. In this study we present…”
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A disordered region retains the full protease inhibitor activity and the capacity to induce CD8+ T cells in vivo of the oral vaccine adjuvant U-Omp19 by Laura Darriba, M., Castro, Celeste Pueblas, Coria, Lorena M., Bruno, Laura, Laura Cerutti, M., Otero, Lisandro H., Chemes, Lucía B., Rasia, Rodolfo M., Klinke, Sebastián, Cassataro, Juliana, Pasquevich, Karina A.

“…[Display omitted] U-Omp19 is a bacterial protease inhibitor from Brucella abortus that inhibits gastrointestinal and lysosomal proteases, enhancing the…”
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Brucella abortus Omp19 recombinant protein subcutaneously co-delivered with an antigen enhances antigen-specific T helper 1 memory responses and induces protection against parasite challenge by Coria, Lorena M, Ibañez, Andrés E, Pasquevich, Karina A, Cobiello, Paula L. González, Frank, Fernanda M, Giambartolomei, Guillermo H, Cassataro, Juliana

“…Abstract The discovery of effective adjuvants for many vaccines especially those with limited commercial appeal, such as vaccines to poverty-related diseases,…”
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