Search Results - "Pasquale, Eric Di"
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MT5-MMP promotes neuroinflammation, neuronal excitability and Aβ production in primary neuron/astrocyte cultures from the 5xFAD mouse model of Alzheimer's disease
Published in Journal of neuroinflammation (11-03-2022)“…Membrane-type matrix metalloproteinase 5 (MT5-MMP) deficiency in the 5xFAD mouse model of Alzheimer's disease (AD) reduces brain neuroinflammation and…”
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2
Hydrolytic Fate of 3/15-Acetyldeoxynivalenol in Humans: Specific Deacetylation by the Small Intestine and Liver Revealed Using in Vitro and ex Vivo Approaches
Published in Toxins (28-07-2016)“…In addition to deoxynivalenol (DON), acetylated derivatives, i.e., 3-acetyl and 15-acetyldexynivalenol (or 3/15ADON), are present in cereals leading to…”
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3
Temporin-SHa and Its Analogs as Potential Candidates for the Treatment of Helicobacter pylori
Published in Biomolecules (Basel, Switzerland) (11-10-2019)“…is one of the most prevalent pathogens colonizing 50% of the world's population and causing gastritis and gastric cancer. Even with triple and quadruple…”
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4
The unusual structure of Ruminococcin C1 antimicrobial peptide confers clinical properties
Published in Proceedings of the National Academy of Sciences - PNAS (11-08-2020)“…The emergence of superbugs developing resistance to antibiotics and the resurgence of microbial infections have led scientists to start an antimicrobial arms…”
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5
Deoxynivalenol inhibits the expression of trefoil factors (TFF) by intestinal human and porcine goblet cells
Published in Archives of toxicology (01-04-2019)“…Trefoil factors (TFFs) are bioactive peptides expressed by several epithelia, including the intestine, where they regulate key functions such as tissue…”
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6
Blockage of bacterial FimH prevents mucosal inflammation associated with Crohn’s disease
Published in Microbiome (23-08-2021)“…Background An Escherichia coli (E. coli) pathotype with invasive properties, first reported by Darfeuille-Michaud and termed adherent-invasive E. coli (AIEC),…”
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7
The insertion and transport of anandamide in synthetic lipid membranes are both cholesterol-dependent
Published in PloS one (30-03-2009)“…Anandamide is a lipid neurotransmitter which belongs to a class of molecules termed the endocannabinoids involved in multiple physiological functions…”
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Investigating Host Microbiota Relationships Through Functional Metagenomics
Published in Frontiers in microbiology (2019)“…The human Intestinal mucus is formed by glycoproteins, the O- and N-linked glycans which constitute a crucial source of carbon for commensal gut bacteria,…”
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9
Cellular and synaptic effect of substance P on neonatal phrenic motoneurons
Published in The European journal of neuroscience (01-01-2000)“…Experiments were carried out on the in vitro brainstem–spinal cord preparation of the newborn rat to analyse the effects of substance P (SP) on phrenic…”
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10
Deoxynivalenol inhibits the expression by goblet cells of intestinal mucins through a PKR and MAP kinase dependent repression of the resistin‐like molecule β
Published in Molecular nutrition & food research (01-06-2015)“…SCOPE: The food‐associated mycotoxin deoxynivalenol (DON) is known to affect intestinal functions. However, its effect on intestinal mucus is poorly…”
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11
The Food-Associated Ribotoxin Deoxynivalenol Modulates Inducible NO Synthase in Human Intestinal Cell Model
Published in Toxicological Sciences (01-06-2015)“…The intestinal epithelium possesses active immune functions including the production of proinflammatory cytokines and antimicrobial molecules such as nitric…”
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12
Identification of a muropeptide precursor transporter from gut microbiota and its role in preventing intestinal inflammation
Published in Proceedings of the National Academy of Sciences - PNAS (26-12-2023)“…The gut microbiota is a considerable source of biologically active compounds that can promote intestinal homeostasis and improve immune responses. Here, we…”
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13
MT5-MMP promotes neuroinflammation, neuronal excitability and Aβ production in primary neuron/astrocyte cultures from the 5xFAD mouse model of Alzheimer’s disease
Published in Journal of neuroinflammation (01-12-2022)“…Abstract Background Membrane-type matrix metalloproteinase 5 (MT5-MMP) deficiency in the 5xFAD mouse model of Alzheimer's disease (AD) reduces brain…”
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14
MT5-MMP promotes neuroinflammation, neuronal excitability and A[beta] production in primary neuron/astrocyte cultures from the 5xFAD mouse model of Alzheimer's disease
Published in Journal of neuroinflammation (11-03-2022)“…Background Membrane-type matrix metalloproteinase 5 (MT5-MMP) deficiency in the 5xFAD mouse model of Alzheimer's disease (AD) reduces brain neuroinflammation…”
Get full text
Journal Article -
15
The unusual structure of Ruminococcin C1 antimicrobialpeptide confers clinical properties
Published in Proceedings of the National Academy of Sciences - PNAS (11-08-2020)“…The emergence of superbugs developing resistance to antibiotics and the resurgence of microbial infections have led scientists to start an antimicrobial arms…”
Get full text
Journal Article -
16
Altered Ion Channel Formation by the Parkinson's-Disease-Linked E46K Mutant of α-Synuclein Is Corrected by GM3 but Not by GM1 Gangliosides
Published in Journal of molecular biology (19-03-2010)“…α-Synuclein (α-syn) is an amyloidogenic protein that plays a key role in the pathogenesis of Parkinson's disease (PD). The ability of α-syn oligomers to form…”
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17
Effects of ethanol on respiratory activity in the neonatal rat brainstem-spinal cord preparation
Published in Brain research (16-10-1995)“…Ethanol (1–12 mM) added to the superfusion medium of the isolated brainstem-spinal cords of newborn rats did not affect phrenic activity but significantly…”
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18
The food-associated fungal neurotoxin ochratoxin A inhibits the absorption of glutamate by astrocytes through a decrease in cell surface expression of the excitatory amino-acid transporters GLAST and GLT-1
Published in Neurotoxicology (Park Forest South) (01-09-2010)“…The food-associated mycotoxin ochratoxin A (OTA) has been demonstrated to be deleterious to numerous cell types including brain cells. Although OTA has been…”
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Biophysical studies of the interaction of squalamine and other cationic amphiphilic molecules with bacterial and eukaryotic membranes: importance of the distribution coefficient in membrane selectivity
Published in Chemistry and physics of lipids (01-02-2010)“…The interaction of squalamine (SQ) with eukaryotic and prokaryotic membranes was studied and compared with the interaction of two other cationic amphipathic…”
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20
Increased Excitability and Inward Rectification in Layer V Cortical Pyramidal Neurons in the Epileptic Mutant Mouse Stargazer
Published in Journal of neurophysiology (01-02-1997)“…Eric Di Pasquale , Karl D. Keegan , and Jeffrey L. Noebels Developmental Neurogenetics Laboratory, Department of Neurology, Section of Neurophysiology, Baylor…”
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