Search Results - "Pasis, Angela"

Discovery of CDK4/6 bifunctional degraders for ER+/HER2- breast cancer by Majeski, Hannah, Okano, Akinori, Pasis, Angela, Carlson, Casey, Shakya, Arvind, Huang, Shenlin, Chourasia, Aparajita Hoskote, Fung, Leah M., Liu, Qiao

“…1083 Background: CDK4/6 inhibitors (CDK4/6i) such as palbociclib and ribociclib are used to treat ER+/HER2- breast cancer, but patients can develop resistance…”
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BTX-1188, a first-in-class dual degrader of GSPT1 and IKZF1/3, for treatment of acute myeloid leukemia (AML) and solid tumors by Chourasia, Aparajita Hoskote, Majeski, Hannah, Pasis, Angela, Erdman, Paul, Oke, Ashwini, Hecht, David, Lonergan, David, Mercurio, Frank, Chan, Kyle, Thai, Dung Luong, Fung, Leah

“…7025 Background: BTX-1188 is a first-in-class oral molecular glue that degrades GSPT1 and IKZF1/3 and is currently in phase 1 clinical trials for treatment of…”
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Abstract 1963: Targeting hematological malignancies with two functionally and mechanistically distinct classes of cereblon mediated protein homeostatic modulators by Chourasia, Aparajita Hoskote, Fung, Leah, Pasis, Angela, McElwee, Brooke, Schoolmeesters, Angela, Richard, Normand, Lam, Imelda, Torres, Eduardo, Erdman, Paul, Sullivan, Robert, Hecht, David, Chan, Kyle W., Mercurio, Frank, Stirling, David I.

“…Abstract BioTheryX's novel and unique Protein Homeostatic Modulators (PHMsTM) are small molecule “molecular glues” that promote ubiquitination of substrate…”
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Abstract 1553: Discovery of CDK4/6 bifunctional degraders for ER+/HER2- breast cancer andtriple negative breast cancer by Majeski, Hannah, Okano, Akinori, Pasis, Angela, Carlson, Casey, Liu, Qiao, Shakya, Arvind, Huang, Shenlin, Chourasia, Aparajita Hoskote, Fung, Leah

“…Abstract CDK4/6 inhibitors (CDK4/6i) such as palbociclib and ribociclib are used to treatER+/HER2- breast cancer, but patients can develop resistance via…”
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Abstract PO5-05-02: Discovery of BTX-9341, a bifunctional degrader of CDK4 and CDK6 for HR+/HER2- breast cancer by Majeski, Hannah, Okano, Akinori, Chahal, Kirti, Pasis, Angela, Carlson, Casey, Shakya, Arvind, Liu, Qiao, Huang, Shenlin, Chourasia, Aparajita Hoskote, Fung, Leah

“…Abstract CDK4/6 inhibitors (CDK4/6i) such as palbociclib, abemaciclib and ribociclib are used to treat HR+/HER2- breast cancer, but patients can develop…”
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Abstract 5702: BTX-9341, a bifunctional degrader of CDK4 and CDK6 for glioblastoma multiforme by Majeski, Hannah, Chahal, Kirti, Okano, Akinori, Pasis, Angela, Carlson, Casey, Shakya, Arvind, Liu, Qiao, Huang, Shenlin, Chourasia, Aparajita Hoskote, Fung, Leah

“…Abstract Glioblastoma multiforme (GBM) is an aggressive form of brain cancer with limited treatment options. GBM has a high frequency of dysregulation of the…”
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Abstract 6068: Discovery of BTX-9341, a bifunctional degrader of CDK4 and CDK6 for HR+/HER2- breast cancer by Majeski, Hannah, Okano, Akinori, Chahal, Kirti, Pasis, Angela, Carlson, Casey, Shakya, Arvind, Liu, Qiao, Huang, Shenlin, Chourasia, Aparajita Hoskote, Fung, Leah

“…Abstract CDK4/6 inhibitors (CDK4/6i) such as palbociclib, abemaciclib and ribociclib are used to treat HR+/HER2- breast cancer, but patients can develop…”
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Synthesis, SAR and biological evaluation of 1,6-disubstituted-1H-pyrazolo[3,4-d]pyrimidines as dual inhibitors of Aurora kinases and CDK1 by Le Brazidec, Jean-Yves, Pasis, Angela, Tam, Betty, Boykin, Christina, Black, Cheryl, Wang, Deping, Claassen, Gisela, Chong, Jer-Hong, Chao, Jianhua, Fan, Junhua, Nguyen, Khanh, Silvian, Laura, Ling, Leona, Zhang, Lin, Choi, Michael, Teng, Min, Pathan, Nuzhat, Zhao, Shuo, Li, Tony, Taveras, Art

“…Since the early 2000s, the Aurora kinases have become major targets of oncology drug discovery particularly Aurora-A and Aurora-B kinases (AKA/AKB) for which…”
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Structure-based design of 2,6,7-trisubstituted-7H-pyrrolo[2,3-d]pyrimidines as Aurora kinases inhibitors by Le Brazidec, Jean-Yves, Pasis, Angela, Tam, Betty, Boykin, Christina, Wang, Deping, Marcotte, Douglas J., Claassen, Gisela, Chong, Jer-Hong, Chao, Jianhua, Fan, Junhua, Nguyen, Khanh, Silvian, Laura, Ling, Leona, Zhang, Lin, Choi, Michael, Teng, Min, Pathan, Nuzhat, Zhao, Shuo, Li, Tony, Taveras, Art

“…This Letter reports the optimization of a pyrrolopyrimidine series as dual inhibitors of Aurora A/B kinases. This series derived from a pyrazolopyrimidine…”
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Abstract 2817: Preclinical studies of the PI3K/mTOR dual inhibitors in endometrial cancer cell lines by Yuan, Jing, Garza, Scott J., Cao, Joan, Fisher, Timothy S., Lee, Nathan V., Eisele, Koleen, Pasis, Angela, Hook, Kenneth, Christensen, James G., Kan, Julie L.

“…Abstract The PI3K pathway plays a pivotal role in many cellular functions that include regulation of cell proliferation, survival, growth, angiogenesis, and…”
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