Search Results - "Pasinetti, G"

Identification of potential CSF biomarkers in ALS by PASINETTI, G. M, UNGAR, L. H, MARCUS, S, HO, L, LANGEE, D. J, YEMUL, S, DENG, H, YUAN, X, BROWN, R. H, CUDKOWICZ, M. E, NEWHALL, K, PESKIND, E

“…The clinical diagnosis of ALS is based entirely on clinical features. Identification of biomarkers for ALS would be important for diagnosis and might also…”
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Randomized pilot study of nimesulide treatment in Alzheimer's disease by AISEN, P. S, SCHMEIDLER, J, PASINETTI, G. M

“…Nonsteroidal anti-inflammatory drugs (NSAID) may be useful in the treatment of AD. Clinical and laboratory experience with nimesulide, an NSAID with…”
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The Palaeobiology of Two Crown Group Cnidarians: Haootia quadriformis and Mamsetia manunis gen. et sp. nov. from the Ediacaran of Newfoundland, Canada by McIlroy, D, Pasinetti, G, Pérez-Pinedo, D, McKean, C, Dufour, S C, Matthews, J J, Menon, L R, Nicholls, R, Taylor, R S

“…The Ediacaran of eastern Newfoundland preserves the world's oldest known eumetazoan body fossils, as well as the earliest known record of fossilized muscular…”
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Cyclooxygenase-2 expression is increased in frontal cortex of Alzheimer's disease brain by Pasinetti, G.M, Aisen, P.S

“…Many epidemiological studies suggest that use of non-steroidal anti-inflammatory drugs delays or slows the clinical expression of Alzheimer's disease, [13]but…”
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Granins as disease-biomarkers: translational potential for psychiatric and neurological disorders by Bartolomucci, A, Pasinetti, G.M, Salton, S.R.J

“…Abstract The identification of biomarkers represents a fundamental medical advance that can lead to an improved understanding of disease pathogenesis, and…”
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Rheotropic Epifaunal Growth, Not Felling by Density Currents, Is Responsible for Many Ediacaran Fossil Orientations at Mistaken Point by McIlroy, D., Pérez-Pinedo, D., Pasinetti, G., McKean, C., Taylor, R. S., Hiscott, R. N.

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P2.192 Molecular diagnostics of parkinsonism in asymptomatic subjects at high risk for disease onset and progression by Pasinetti, G

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A therapeutic role for cyclooxygenase‐2 inhibitors in a transgenic mouse model of amyotrophic lateral sclerosis by Pompl, P. N., Ho, L., Bianchi, M., McManus, T., Qin, W., Pasinetti, G. M.

“…ABSTRACT Recent studies indicate that the proinflammatory enzyme cyclooxygenase (COX)‐2, an enzyme involved in inflammatory cascades but also normal neuronal…”
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Potentiation of Excitotoxicity in Transgenic Mice Overexpressing Neuronal Cyclooxygenase-2 by Kelley, Kevin A., Ho, Lap, Winger, David, Freire-Moar, Jose, Borelli, Cy Blanco, Aisen, Paul S., Pasinetti, Giulio Maria

“…In this study we describe the generation of a transgenic mouse model with neuronal overexpression of the human cyclooxygenase-2, h(COX)-2, to explore its role…”
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Cyclooxygenase and Alzheimer's disease: implications for preventive initiatives to slow the progression of clinical dementia by Pasinetti, Giulio Maria

“…Industry and academia are devoting a tremendous amount of resources to the testing of anti-inflammatory drugs for the treatment of Alzheimer's disease (AD)…”
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Use of cDNA microarray in the search for molecular markers involved in the onset of Alzheimer's disease dementia by Pasinetti, Giulio Maria

“…Alzheimer's disease (AD) is the most common form of dementia, affecting as many as 4 million older persons and results from abnormal changes in the brain that…”
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Inhibition of cyclooxygenase as potential novel therapeutic strategy in N141I presenilin-2 familial Alzheimer's disease by Qin, W, Peng, Y, Ksiezak-Reding, H, Ho, L, Stetka, B, Lovati, E, Pasinetti, G M

“…The present study was designed to further explore the potential cause/effect relationship between the expression of both the N141I presenilin (PS)2 mutant…”
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Maturational Regulation and Regional Induction of Cyclooxygenase-2 in Rat Brain: Implications for Alzheimer's Disease by Tocco, G., Freire-Moar, J., Schreiber, S.S., Sakhi, S.H., Aisen, P.S., Pasinetti, G.M.

“…We explored the constitutive expression, maturational regulation, and relation to kainic-acid-induced apoptosis of cyclooxygenase (COX)-2 mRNA in rat brain. In…”
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Phosphorylation of tau at THR212 and SER214 in human neuronal and glial cultures: The role of AKT by Kyoung Pyo, H, Lovati, E, Pasinetti, G.M, Ksiezak-Reding, H

“…We have reported recently that the microtubule-associated protein tau is phosphorylated in vitro by Akt, an important kinase in anti-apoptotic signaling…”
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Protein Kinase C Anchoring Deficit in Postmortem Brains of Alzheimer's Disease Patients by Battaini, Fiorenzo, Pascale, Alessia, Lucchi, Laura, Pasinetti, Giulio M., Govoni, Stefano

“…Protein kinase C (PKC) has been implicated in the pathophysiology of Alzheimer's disease (AD). The levels of particular isoforms and the activation of PKC are…”
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Clusterin (apoJ) Alters the Aggregation of Amyloid β-Peptide (Aβ 1-42) and Forms Slowly Sedimenting Aβ Complexes That Cause Oxidative Stress by Oda, Tomiichiro, Wals, Pat, Osterburg, Heinz H., Johnson, Steven A., Pasinetti, Giulio M., Morgan, Todd E., Rozovsky, Irina, Stine, W.Blaine, Snyder, Seth W., Holzman, Thomas F., Krafft, Grant A., Finch, Caleb E.

“…Clusterin (apoJ), a multifunctional apolipoprotein made by cells in the brain and many other locations, is associated with aggregated amyloid β-peptide (Aβ) in…”
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Complement anaphylatoxin C5a neuroprotects through mitogen‐activated protein kinase‐dependent inhibition of caspase 3 by Mukherjee, Piali, Pasinetti, Giulio Maria

“…We previously reported that pretreatment of murine cortico‐hippocampal neuronal cultures with the complement‐derived anaphylatoxin C5a, protects against…”
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Expression of C5a receptor in mouse brain: role in signal transduction and neurodegeneration by Osaka, H., McGinty, A., Höpken, U.E., Lu, B., Gerard, C., Pasinetti, G.M.

“…In this study we explored the potential role of the complement derived anaphylatoxin C5a and the expression of its receptor in mouse brain. Using in situ…”
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Cyclooxygenase-2 Promotes Amyloid Plaque Deposition in a Mouse Model of Alzheimer's Disease Neuropathology by Xiang, Zhongmin, Ho, Lap, Yemul, Shrishailam, Zhao, Zhong, Qing, Wein, Pompl, Patrick, Kelley, Kevin, Dang, Anju, Qing, Weiping, Teplow, David, Pasinetti, Giulio Maria

“…Several epidemiologic studies have reported that cyclooxygenase (COX) inhibitors prevent/delay the onset of Alzheimer's disease (AD). Recent experimental…”
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Cyclooxygenase and inflammation in Alzheimer's disease: Experimental approaches and clinical interventions by Pasinetti, Giulio Maria

“…Many epidemiological studies suggest that use of non‐steroidal anti‐inflammatory drugs (NSAIDs) delay or slow the clinical expression of Alzheimer's disease…”
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