Search Results - "Pasillas, Martina P."

An environment-dependent transcriptional network specifies human microglia identity by Gosselin, David, Skola, Dylan, Coufal, Nicole G., Holtman, Inge R., Schlachetzki, Johannes C. M., Sajti, Eniko, Jaeger, Baptiste N., O’Connor, Carolyn, Fitzpatrick, Conor, Pasillas, Martina P., Pena, Monique, Adair, Amy, Gonda, David D., Levy, Michael L., Ransohoff, Richard M., Gage, Fred H., Glass, Christopher K.

“…Microglia play essential roles in central nervous system (CNS) homeostasis and influence diverse aspects of neuronal function. However, the transcriptional…”
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Niche-Specific Reprogramming of Epigenetic Landscapes Drives Myeloid Cell Diversity in Nonalcoholic Steatohepatitis by Seidman, Jason S., Troutman, Ty D., Sakai, Mashito, Gola, Anita, Spann, Nathanael J., Bennett, Hunter, Bruni, Cassi M., Ouyang, Zhengyu, Li, Rick Z., Sun, Xiaoli, Vu, BaoChau T., Pasillas, Martina P., Ego, Kaori M., Gosselin, David, Link, Verena M., Chong, Ling-Wa, Evans, Ronald M., Thompson, Bonne M., McDonald, Jeffrey G., Hosseini, Mojgan, Witztum, Joseph L., Germain, Ronald N., Glass, Christopher K.

“…Tissue-resident and recruited macrophages contribute to both host defense and pathology. Multiple macrophage phenotypes are represented in diseased tissues,…”
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Heterogeneity of HSCs in a Mouse Model of NASH by Rosenthal, Sara Brin, Liu, Xiao, Ganguly, Souradipta, Dhar, Debanjan, Pasillas, Martina P., Ricciardelli, Eugenia, Li, Rick Z., Troutman, Ty D., Kisseleva, Tatiana, Glass, Christopher K., Brenner, David A.

“…Background and Aims In clinical and experimental NASH, the origin of the scar‐forming myofibroblast is the HSC. We used foz/foz mice on a Western diet to…”
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Quantitative production of macrophages or neutrophils ex vivo using conditional Hoxb8 by Kamps, Mark P, Wang, Gang G, Calvo, Katherine R, Pasillas, Martina P, Sykes, David B, Häcker, Hans

“…Differentiation mechanisms and inflammatory functions of neutrophils and macrophages are usually studied by genetic and biochemical approaches that require…”
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Proteomic Analysis Reveals a Role for Bcl2-associated Athanogene 3 and Major Vault Protein in Resistance to Apoptosis in Senescent Cells by Regulating ERK1/2 Activation by Pasillas, Martina P., Shields, Sarah, Reilly, Rebecca, Strnadel, Jan, Behl, Christian, Park, Robin, Yates, John R., Klemke, Richard, Gonias, Steven L., Coppinger, Judith A.

“…Senescence is a prominent solid tumor response to therapy in which cells avoid apoptosis and instead enter into prolonged cell cycle arrest. We applied a…”
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NSD1 PHD domains bind methylated H3K4 and H3K9 using interactions disrupted by point mutations in human sotos syndrome by Pasillas, Martina P, Shah, Meera, Kamps, Mark P

“…Sotos syndrome is a human developmental and cognitive disorder caused by happloinsufficiency of transcription factor NSD1. Similar phenotypes arise from NSD1…”
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Persistent Transactivation by Meis1 Replaces Hox Function in Myeloid Leukemogenesis Models: Evidence for Co-Occupancy of Meis1-Pbx and Hox-Pbx Complexes on Promoters of Leukemia-Associated Genes by Wang, Gang G., Pasillas, Martina P., Kamps, Mark P.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Liver-Derived Signals Sequentially Reprogram Myeloid Enhancers to Initiate and Maintain Kupffer Cell Identity by Sakai, Mashito, Troutman, Ty D., Seidman, Jason S., Ouyang, Zhengyu, Spann, Nathanael J., Abe, Yohei, Ego, Kaori M., Bruni, Cassi M., Deng, Zihou, Schlachetzki, Johannes C.M., Nott, Alexi, Bennett, Hunter, Chang, Jonathan, Vu, BaoChau T., Pasillas, Martina P., Link, Verena M., Texari, Lorane, Heinz, Sven, Thompson, Bonne M., McDonald, Jeffrey G., Geissmann, Frederic, Glass, Christopher K.

“…Tissue environment plays a powerful role in establishing and maintaining the distinct phenotypes of resident macrophages, but the underlying molecular…”
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Brain cell type-specific enhancer-promoter interactome maps and disease - risk association by Nott, Alexi, Holtman, Inge R, Coufal, Nicole G, Schlachetzki, Johannes C M, Yu, Miao, Hu, Rong, Han, Claudia Z, Pena, Monique, Xiao, Jiayang, Wu, Yin, Keulen, Zahara, Pasillas, Martina P, O'Connor, Carolyn, Nickl, Christian K, Schafer, Simon T, Shen, Zeyang, Rissman, Robert A, Brewer, James B, Gosselin, David, Gonda, David D, Levy, Michael L, Rosenfeld, Michael G, McVicker, Graham, Gage, Fred H, Ren, Bing, Glass, Christopher K

“…Noncoding genetic variation is a major driver of phenotypic diversity, but functional interpretation is challenging. To better understand common genetic…”
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TREM2-independent microgliosis promotes tau-mediated neurodegeneration in the presence of ApoE4 by Gratuze, Maud, Schlachetzki, Johannes C.M., D’Oliveira Albanus, Ricardo, Jain, Nimansha, Novotny, Brenna, Brase, Logan, Rodriguez, Lea, Mansel, Clayton, Kipnis, Michal, O’Brien, Sydney, Pasillas, Martina P., Lee, Choonghee, Manis, Melissa, Colonna, Marco, Harari, Oscar, Glass, Christopher K., Ulrich, Jason D., Holtzman, David M.

“…In addition to tau and Aβ pathologies, inflammation plays an important role in Alzheimer’s disease (AD). Variants in APOE and TREM2 increase AD risk. ApoE4…”
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NUP98-NSD1 links H3K36 methylation to Hox-A gene activation and leukaemogenesis by Wang, Gang G, Kamps, Mark P, Cai, Ling, Pasillas, Martina P

“…Nuclear receptor-binding SET domain protein 1 (NSD1) prototype is a family of mammalian histone methyltransferases (NSD1, NSD2/MMSET/WHSC1, NSD3/WHSC1L1) that…”
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Discrimination of cell-intrinsic and environment-dependent effects of natural genetic variation on Kupffer cell epigenomes and transcriptomes by Bennett, Hunter, Troutman, Ty D., Zhou, Enchen, Spann, Nathanael J., Link, Verena M., Seidman, Jason S., Nickl, Christian K., Abe, Yohei, Sakai, Mashito, Pasillas, Martina P., Marlman, Justin M., Guzman, Carlos, Hosseini, Mojgan, Schnabl, Bernd, Glass, Christopher K.

“…Noncoding genetic variation drives phenotypic diversity, but underlying mechanisms and affected cell types are incompletely understood. Here, investigation of…”
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Somatic mosaicism reveals clonal distributions of neocortical development by Breuss, Martin W., Yang, Xiaoxu, Schlachetzki, Johannes C. M., Antaki, Danny, Lana, Addison J., Xu, Xin, Chung, Changuk, Chai, Guoliang, Stanley, Valentina, Song, Qiong, Newmeyer, Traci F., Nguyen, An, O’Brien, Sydney, Hoeksema, Marten A., Cao, Beibei, Nott, Alexi, McEvoy-Venneri, Jennifer, Pasillas, Martina P., Barton, Scott T., Copeland, Brett R., Nahas, Shareef, Van Der Kraan, Lucitia, Ding, Yan, Glass, Christopher K., Gleeson, Joseph G.

“…The structure of the human neocortex underlies species-specific traits and reflects intricate developmental programs. Here we sought to reconstruct processes…”
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Meis1a Suppresses Differentiation by G-CSF and Promotes Proliferation by SCF: Potential Mechanisms of Cooperativity with Hoxa9 in Myeloid Leukemia by Calvo, Katherine R., Knoepfler, Paul S., Sykes, David B., Pasillas, Martina P., Kamps, Mark P.

“…Hoxa9 and Meis1a are homeodomain transcription factors that heterodimerize on DNA and are down-regulated during normal myeloid differentiation. Hoxa9 and…”
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SALL1 enforces microglia-specific DNA binding and function of SMADs to establish microglia identity by Fixsen, Bethany R., Han, Claudia Z., Zhou, Yi, Spann, Nathanael J., Saisan, Payam, Shen, Zeyang, Balak, Christopher, Sakai, Mashito, Cobo, Isidoro, Holtman, Inge R., Warden, Anna S., Ramirez, Gabriela, Collier, Jana G., Pasillas, Martina P., Yu, Miao, Hu, Rong, Li, Bin, Belhocine, Sarah, Gosselin, David, Coufal, Nicole G., Ren, Bing, Glass, Christopher K.

“…Spalt-like transcription factor 1 (SALL1) is a critical regulator of organogenesis and microglia identity. Here we demonstrate that disruption of a conserved…”
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Human microglia maturation is underpinned by specific gene regulatory networks by Han, Claudia Z., Li, Rick Z., Hansen, Emily, Trescott, Samantha, Fixsen, Bethany R., Nguyen, Celina T., Mora, Cristina M., Spann, Nathanael J., Bennett, Hunter R., Poirion, Olivier, Buchanan, Justin, Warden, Anna S., Xia, Bing, Schlachetzki, Johannes C.M., Pasillas, Martina P., Preissl, Sebastian, Wang, Allen, O’Connor, Carolyn, Shriram, Shreya, Kim, Roy, Schafer, Danielle, Ramirez, Gabriela, Challacombe, Jean, Anavim, Samuel A., Johnson, Avalon, Gupta, Mihir, Glass, Ian A., Levy, Michael L., Haim, Sharona Ben, Gonda, David D., Laurent, Louise, Hughes, Jennifer F., Page, David C., Blurton-Jones, Mathew, Glass, Christopher K., Coufal, Nicole G.

“…Microglia phenotypes are highly regulated by the brain environment, but the transcriptional networks that specify the maturation of human microglia are poorly…”
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Novel Genes Critical for Hypoxic Preconditioning in Zebrafish Are Regulators of Insulin and Glucose Metabolism by Manchenkov, Tania, Pasillas, Martina P, Haddad, Gabriel G, Imam, Farhad B

“…Severe hypoxia is a common cause of major brain, heart, and kidney injury in adults, children, and newborns. However, mild hypoxia can be protective against…”
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Meis1 programs transcription of FLT3 and cancer stem cell character, using a mechanism that requires interaction with Pbx and a novel function of the Meis1 C-terminus by Wang, Gang G., Pasillas, Martina P., Kamps, Mark P.

“…Meis1 is a homeodomain transcription factor coexpressed with Hoxa9 in most human acute myeloid leukemias (AMLs). In mouse models of leukemia produced by Hoxa9,…”
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Nup98-HoxA9 immortalizes myeloid progenitors, enforces expression of Hoxa9, Hoxa7 and Meis1, and alters cytokine-specific responses in a manner similar to that induced by retroviral co-expression of Hoxa9 and Meis1 by CALVO, Katherine R, SYKES, David B, PASILLAS, Martina P, KAMPS, Mark P

“…The association between acute myeloid leukaemia (AML) and the aberrant expression of Hoxa9 is evidenced by (1) proviral activation of Hoxa9 and Meis1 in BXH-2…”
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Heterogeneity of hepatic stellate cells in a mouse model of non-alcoholic steatohepatitis (NASH) by Rosenthal, Sara Brin, Liu, Xiao, Ganguly, Souradipta, Dhar, Debanjan, Pasillas, Martina P., Ricciardelli, Eugenia, Li, Rick Z., Troutman, Ty D., Kisseleva, Tatiana, Glass, Christopher K., Brenner, David A.

“…In clinical and experimental non-alcoholic steatohepatitis (NASH), the origin of the scar-forming myofibroblast is the hepatic stellate cell (HSC). We used…”
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