Search Results - "Pashos, E"

The plasma proteome of tangier disease patients reveals perturbations of diabetic and inflammatory pathways by McParland, J, Pashos, E, Rader, D, Cuchel, M

Get full text

Lack of MTTP Activity in Pluripotent Stem Cell-Derived Hepatocytes and Cardiomyocytes Abolishes apoB Secretion and Increases Cell Stress by Liu, Ying, Conlon, Donna M., Bi, Xin, Slovik, Katherine J., Shi, Jianting, Edelstein, Hailey I., Millar, John S., Javaheri, Ali, Cuchel, Marina, Pashos, Evanthia E., Iqbal, Jahangir, Hussain, M. Mahmood, Hegele, Robert A., Yang, Wenli, Duncan, Stephen A., Rader, Daniel J., Morrisey, Edward E.

“…Abetalipoproteinemia (ABL) is an inherited disorder of lipoprotein metabolism resulting from mutations in microsomal triglyceride transfer protein (MTTP). In…”
Get full text

ATP-Binding Cassette Transporter A1 Deficiency in Human Induced Pluripotent Stem Cell-Derived Hepatocytes Abrogates HDL Biogenesis and Enhances Triglyceride Secretion by Bi, Xin, Pashos, Evanthia E., Cuchel, Marina, Lyssenko, Nicholas N., Hernandez, Mayda, Picataggi, Antonino, McParland, James, Yang, Wenli, Liu, Ying, Yan, Ruilan, Yu, Christopher, DerOhannessian, Stephanie L., Phillips, Michael C., Morrisey, Edward E., Duncan, Stephen A., Rader, Daniel J.

“…Despite the recognized role of the ATP-binding Cassette Transporter A1 (ABCA1) in high-density lipoprotein (HDL) metabolism, our understanding of ABCA1…”
Get full text

Tangier disease ipsc-derived hepatocytes recapitulate HDL biogenesis defects and display elevated triglyceride secretion by Pashos, E, Lyssenko, N.N, Picataggi, A, Hernandez, M, Liu, Y, Yan, R, Yang, W, Morrisey, E.E, Duncan, S.A, Rader, D.J

Get full text

Outcomes of Periacetabular Osteotomy for Borderline Acetabular Dysplasia by Nepple, Jeffrey J., Parilla, Frank W., Pashos, Gail E., Clohisy, John C.

“…The optimal surgical treatment (hip arthroscopy compared with periacetabular osteotomy [PAO]) for borderline acetabular dysplasia (lateral center-edge angle…”
Get full text

Fifteen-Year Results of Total Hip Arthroplasty With Cobalt-Chromium Femoral Heads on Highly Cross-Linked Polyethylene in Patients 50 Years and Less by Rames, Richard D., Stambough, Jeffrey B., Pashos, Gail E., Maloney, William J., Martell, John M., Clohisy, John C.

“…Highly cross-linked polyethylene (HXLPE) is the most commonly used bearing surface in total hip arthroplasty (THA) because of its superior wear properties, but…”
Get full text

Ten Year Outcomes of Contemporary Total Hip Arthroplasty in Adolescent and Young Adult Patients are Favorable by Parilla, Frank W., Anthony, Chris A., Bartosiak, Kimberly A., Pashos, Gail E., Thapa, Susan, Clohisy, John C.

“…The purpose of this study was to assess 10-year patient-reported outcome measures, complications, polyethylene wear-rates, and implant survivorships in…”
Get full text

Large, Diverse Population Cohorts of hiPSCs and Derived Hepatocyte-like Cells Reveal Functional Genetic Variation at Blood Lipid-Associated Loci by Pashos, Evanthia E., Park, YoSon, Wang, Xiao, Raghavan, Avanthi, Yang, Wenli, Abbey, Deepti, Peters, Derek T., Arbelaez, Juan, Hernandez, Mayda, Kuperwasser, Nicolas, Li, Wenjun, Lian, Zhaorui, Liu, Ying, Lv, Wenjian, Lytle-Gabbin, Stacey L., Marchadier, Dawn H., Rogov, Peter, Shi, Jianting, Slovik, Katherine J., Stylianou, Ioannis M., Wang, Li, Yan, Ruilan, Zhang, Xiaolan, Kathiresan, Sekar, Duncan, Stephen A., Mikkelsen, Tarjei S., Morrisey, Edward E., Rader, Daniel J., Brown, Christopher D., Musunuru, Kiran

“…Genome-wide association studies have struggled to identify functional genes and variants underlying complex phenotypes. We recruited a multi-ethnic cohort of…”
Get full text

Interrogation of the Atherosclerosis-Associated SORT1 (Sortilin 1) Locus With Primary Human Hepatocytes, Induced Pluripotent Stem Cell-Hepatocytes, and Locus-Humanized Mice by Wang, Xiao, Raghavan, Avanthi, Peters, Derek T, Pashos, Evanthia E, Rader, Daniel J, Musunuru, Kiran

“…OBJECTIVE—The noncoding single-nucleotide polymorphism rs12740374 has been hypothesized to be the causal variant responsible for liver-specific modulation of…”
Get full text

Mean 16-Year Results of Total Hip Arthroplasty With Alumina Ceramic Femoral Heads on Highly Cross-Linked Polyethylene in Patients 50 Years or Less by Youngman, Tyler R., Verhotz, Daniel R., Layon, Daniel R., Parilla, Frank W., Pashos, Gail E., Thornton, Tanner, Bendich, Ilya, Clohisy, John C.

“…Highly cross-linked polyethylene (HXLPE) is a widely used bearing surface in total hip arthroplasty (THA); long-term results in young patients are limited. We…”
Get full text

Functional Analysis and Transcriptomic Profiling of iPSC-Derived Macrophages and Their Application in Modeling Mendelian Disease by Zhang, Hanrui, Xue, Chenyi, Shah, Rhia, Bermingham, Kate, Hinkle, Christine C, Li, Wenjun, Rodrigues, Amrith, Tabita-Martinez, Jennifer, Millar, John S, Cuchel, Marina, Pashos, Evanthia E, Liu, Ying, Yan, Ruilan, Yang, Wenli, Gosai, Sager J, VanDorn, Daniel, Chou, Stella T, Gregory, Brian D, Morrisey, Edward E, Li, Mingyao, Rader, Daniel J, Reilly, Muredach P

“…RATIONALE:An efficient and reproducible source of genotype-specific human macrophages is essential for study of human macrophage biology and related diseases…”
Get full text

Long-Term Follow-Up of Conventional Polyethylene in Total Hip Arthroplasty in Young Patients: Heightened Wear-Related Complications Are Observed at the Beginning of the Third Decade by Parilla, Frank W., Ince, Deniz C., Pashos, Gail E., Maloney, William J., Clohisy, John C.

“…Conventional polyethylene (CPE) was used widely in the past as a bearing surface in total hip arthroplasty (THA). As CPE THAs age and the revision burden…”
Get full text

Pluripotency Redux — Advances in Stem-Cell Research by Gearhart, John, Pashos, Evanthia E, Prasad, Megana K

“…Deciphering the molecular basis of pluripotency will facilitate the development of procedures for efficiently deriving patient-specific stem cells. Dr. John…”
Get full text

Excellent 20-Year Results of Total Hip Arthroplasty With Highly Cross-Linked Polyethylene on Cobalt-Chromium Femoral Heads in Patients ≤50 Years by Parilla, Frank W, Youngman, Tyler R, Layon, Daniel R, Ince, Deniz C, Pashos, Gail E, Maloney, William J, Clohisy, John C

“…Highly cross-linked polyethylene (HXLPE) acetabular bearing surfaces have appeared to offer excellent wear resistance, low incidence of wear-related…”
Get full text

Incidence and Characteristics of Osteolysis in HXLPE THA at 16-Year Follow up in Patients 50 Years and Less by Rames, Richard D., Hillen, Travis J., Pashos, Gail E., Maloney, William J., Clohisy, John C.

“…Young patients present a challenge for total hip arthroplasty (THA) survivorship. Highly cross-linked polyethylene (HXLPE) liners have decreased the prevalence…”
Get full text

Total Hip Arthroplasty in Patients With Osteoarthritis Associated With Legg-Calve-Perthes Disease: Perioperative Complications and Patient-Reported Outcomes by Anthony, Chris A., Wasko, Marcin K., Pashos, Gail E., Barrack, Robert L., Nunley, Ryan M., Clohisy, John C.

“…Complications and patient-reported outcomes (PROs) of total hip arthroplasty (THA) in patients with Legg-Calve-Perthes disease (LCPD) have demonstrated…”
Get full text

Conventional Polyethylene in Total Hip Arthroplasty in Young Patients: Survivorship, Wear Analysis, and Clinical Outcomes Between 15 and 20 Years by Stambough, Jeffrey B., Rames, Richard D., Pashos, Gail E., Maloney, William J., Martell, John M., Clohisy, John C.

“…Total hip arthroplasty (THA) remains a successful procedure for most patients. However, there is a paucity of information regarding the long-term performance…”
Get full text

Outcomes of Revision Total Hip Arthroplasty in Patients 60 Years and Younger by Parilla, Frank W, Hannon, Charles P, Pashos, Gail E, Gresham, Karla J, Clohisy, John C

“…The annual volume of patients requiring revision total hip arthroplasty prior to age 60 is projected to increase considerably. Despite this, outcome data for…”
Get full text

Severe Hip Dysplasia in Skeletally Mature Patients With Spastic Cerebral Palsy: The Technique and Early Outcome of Comprehensive Surgical Correction (Including the Bernese PAO) by Miller, Mark L., Clohisy, John C., Pashos, Gail E., Berglund, Lisa M., Schoenecker, Perry L.

“…BACKGROUND:Treatment of symptomatic hip dysplasia in skeletally mature patients with spastic cerebral palsy (CP) can be challenging. This study examines our…”
Get full text

Comparison of modern periacetabular osteotomy for hip dysplasia with total hip arthroplasty for hip osteoarthritis—10-year outcomes are comparable in young adult patients by Parilla, Frank W, Freiman, Serena, Pashos, Gail E, Thapa, Susan, Clohisy, John C

“…ABSTRACT Young adult patients with symptomatic acetabular dysplasia and marginal secondary osteoarthritis can be faced with the decision to either undergo…”
Get full text