Comparative analysis of the development mechanisms of cryoglobulinemic vasculitis and Sjögren's syndrome

Cryoglobulinemic vasculitis is a disease characterized by damage of small vessels and in some cases can be a manifestation of mixed cryoglobulinemia. Mixed cryoglobulinemia is a condition in which immunoglobulins in the blood serum form precipitates at temperatures below 37 °C and dissolve again whe...

Full description

Saved in:

Bibliographic Details
Published in:	Arkhiv patologii Vol. 86; no. 1; p. 52
Main Authors:	Ponomarev, A B, Pashayeva, K R, Feyziyeva, N Yu
Format:	Journal Article
Language:	English Russian
Published:	Russia (Federation) 2024
Subjects:	Cryoglobulinemia - complications Hepatitis C Humans Sjogren's Syndrome - complications Vasculitis cryoglobulinemic vasculitis hepatitis C virus comparative analysis Sjögren’s syndrome
Online Access:	Get more information
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Cryoglobulinemic vasculitis is a disease characterized by damage of small vessels and in some cases can be a manifestation of mixed cryoglobulinemia. Mixed cryoglobulinemia is a condition in which immunoglobulins in the blood serum form precipitates at temperatures below 37 °C and dissolve again when it rises. Currently, hepatitis C (HCV) is considered the most common etiological factor of mixed cryoglobulinemia. In addition, mixed cryoglobulinemia may be associated with other infectious agents, as well as autoimmune and lymphoproliferative diseases. In the absence of such association, we can talk about essential mixed cryoglobulinemia. To understand how different nosologies in their clinical and morphological picture lead to the development of mixed cryoglobulinemia, it is necessary to carefully analyze the mechanisms of the development of some of them, namely, HCV-associated cryoglobulinemic vasculitis and Sjögren's syndrome. It is noteworthy that mixed cryoglobulinemia in relation to Sjögren's syndrome can be perceived both as its consequence and as a manifestation of the underlying disease. Such an ambiguous nature of mixed cryoglobulinemia makes it currently impossible to select clear diagnostic criteria. For this reason, it is necessary to carry out a comparison between different immunopathogenesis of mixed cryoglobulinemia in order to identify the features that form its classical manifestations.
ISSN:	0004-1955
DOI:	10.17116/patol20248601152