Search Results - "Pasek, Mildred"
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Rituximab for steroid-refractory chronic graft-versus-host disease
Published in Blood (15-07-2006)“…B cells may be implicated in the pathophysiology of chronic graft-versus-host disease (GVHD), as evidenced by antibody production against sex-mismatched, Y…”
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Biologic activity of irradiated, autologous, GM-CSF-secreting leukemia cell vaccines early after allogeneic stem cell transplantation
Published in Proceedings of the National Academy of Sciences - PNAS (15-09-2009)“…Through an immune-mediated graft-versus-leukemia effect, allogeneic hematopoietic stem cell transplantation (HSCT) affords durable clinical benefits for many…”
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3
CTLA4 blockade with ipilimumab to treat relapse of malignancy after allogeneic hematopoietic cell transplantation
Published in Blood (12-02-2009)“…Relapse of malignancy after allogeneic hematopoietic cell transplantation (allo-HCT) remains a therapeutic challenge. Blockade of the CTLA4 molecule can…”
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4
Autologous CLL cell vaccination early after transplant induces leukemia-specific T cells
Published in The Journal of clinical investigation (01-09-2013)“…Patients with advanced hematologic malignancies remain at risk for relapse following reduced-intensity conditioning (RIC) allogeneic hematopoietic stem cell…”
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Autologous Whole Tumor Cell Vaccination Early After Allogeneic Stem Cell Transplantation Elicits Anti-Tumor T Cell Responses in Patients with Advanced Chronic Lymphocytic Leukemia (CLL)
Published in Blood (16-11-2012)“…Abstract 1892▪▪This icon denotes a clinically relevant abstract Patients with advanced hematological malignancies remain at high risk for eventual disease…”
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GM-CSF Secreting Leukemia Cell Vaccination after Allogeneic Reduced Intensity Hematopoietic Stem Cell Transplantation for Advanced Myeloid Malignancies
Published in Blood (16-11-2008)“…Studies have shown that leukemia specific donor immune responses can be elicited by cancer vaccination after allogeneic SCT. Given the likelihood of disease…”
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GM-CSF Secreting Leukemia Cell Vaccinations after Allogeneic Reduced-Intensity Peripheral Blood Stem Cell Transplantation (SCT) for Advanced Myelodysplastic Syndrome (MDS) or Refractory Acute Myeloid Leukemia (AML)
Published in Blood (16-11-2006)“…Disease relapse is a frequent cause of treatment failure in patients undergoing reduced intensity allogeneic stem cell transplantation for advanced MDS and…”
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Clinical Trial of Therapeutic Blockade of CTLA4 with Ipilimumab in Patients with Relapse of Malignancy Following Allogeneic Hematopoietic Transplantation
Published in Blood (16-11-2007)“…Relapse/progression of malignancy (RM) is an important cause of treatment failure and death following allogeneic hematopoietic stem cell transplantation…”
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Phase I Study of Ipilimumab (Neutralizing Monoclonal Anti-CTLA4 Antibody) To Treat Relapse of Malignancy after Allogeneic Hematopoietic Stem Cell Transplantation: Evidence of Tumor Regression without Induction of GVHD
Published in Blood (16-11-2006)“…Failure of adoptive cellular immunotherapy is an important cause of relapse of malignancy (RM) and death following allogeneic hematopoietic stem cell…”
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Phase I Study of a Neutralizing Monoclonal Anti-CTLA4 Antibody (MDX-010) in Patients with Relapse of Malignancy after Allogeneic Hematopoietic Stem Cell Transplantation
Published in Blood (16-11-2005)“…Relapse of malignancy is an important cause of treatment failure after allogeneic hematopoietic stem cell transplantation (allo-HCT). Malignant cells may evade…”
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Rituximab Therapy for Steroid-Refractory Chronic GVHD: Safety and Efficacy Analysis
Published in Blood (16-11-2004)“…The mechanism of tissue injury in chronic GVHD (cGVHD) is unknown, but donor-derived T cells are thought to be the primary effectors. We demonstrated that…”
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