Cholecalciferol 20 000 IU Once Weekly in HIV-Positive Patients with Low Vitamin D Levels: Result from a Cohort Study

Purpose: To evaluate efficacy and safety of 20 000 IU cholecalciferol weekly in HIV-infected patients. Methods: Longitudinal data for 243 HIV-infected patients with paired 25-OH-vitamin D3 values for the same month in 2 consecutive years were stratified by the initiation of supplementation in this r...

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Published in:	Journal of the International Association of Providers of AIDS Care Vol. 16; no. 4; pp. 315 - 320
Main Authors:	Noe, Sebastian, Heldwein, Silke, Pascucchi, Rita, Oldenbüttel, Celia, Wiese, C., von Krosigk, Ariane, Jägel-Guedes, Eva, Jäger, Hans, Mayer, Wolfgang, Spinner, Christoph D., Wolf, Eva
Format:	Journal Article
Language:	English
Published:	Los Angeles, CA SAGE Publications 01-07-2017 SAGE PUBLICATIONS, INC SAGE Publishing
Subjects:	Adult Alkaline Phosphatase - blood Calcium - blood Cholecalciferol - administration & dosage Cohort analysis Female Health risk assessment HIV HIV Seropositivity - complications Human immunodeficiency virus Humans Hypocalcemia - etiology Longitudinal Studies Male Middle Aged Patients Retrospective Studies Vitamin D Vitamin D - blood Vitamin D Deficiency - complications Vitamin D Deficiency - drug therapy Vitamins - administration & dosage supplementation cholecalciferol HIV weekly
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Summary:	Purpose: To evaluate efficacy and safety of 20 000 IU cholecalciferol weekly in HIV-infected patients. Methods: Longitudinal data for 243 HIV-infected patients with paired 25-OH-vitamin D3 values for the same month in 2 consecutive years were stratified by the initiation of supplementation in this retrospective study. Results: After 1 year of administration of cholecalciferol 20 000 IU weekly, about 78% of patients with initial vitamin D level <20 µg/L achieved vitamin D levels >20 µg/L and 42% achieved levels >30 µg/L. Supplemented patients with baseline vitamin D levels <20 µg/L showed a significant risk reduction for hypocalcemia (P = .006; risk difference: 20.8%) and a significantly lower increase in alkaline phosphatase (AP) compared to those in the nonsubstituted group. Conclusion: The dose of 20 000 IU of cholecalciferol once weekly was found to be safe and effective. Normalization of vitamin D levels within 1 year was observed in 42% to 75% of the patients.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	2325-9582 2325-9574 2325-9582
DOI:	10.1177/2325957417702487