Search Results - "Pasche, Boris C"

Diagnosis of thyroid cancer using deep convolutional neural network models applied to sonographic images: a retrospective, multicohort, diagnostic study by Li, Xiangchun, Zhang, Sheng, Zhang, Qiang, Wei, Xi, Pan, Yi, Zhao, Jing, Xin, Xiaojie, Qin, Chunxin, Wang, Xiaoqing, Li, Jianxin, Yang, Fan, Zhao, Yanhui, Yang, Meng, Wang, Qinghua, Zheng, Zhiming, Zheng, Xiangqian, Yang, Xiangming, Whitlow, Christopher T, Gurcan, Metin Nafi, Zhang, Lun, Wang, Xudong, Pasche, Boris C, Gao, Ming, Zhang, Wei, Chen, Kexin

“…The incidence of thyroid cancer is rising steadily because of overdiagnosis and overtreatment conferred by widespread use of sensitive imaging techniques for…”
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IGFBP2 promotes tumor progression by inducing alternative polarization of macrophages in pancreatic ductal adenocarcinoma through the STAT3 pathway by Sun, Longhao, Zhang, Xuebin, Song, Qianqian, Liu, Liang, Forbes, Elizabeth, Tian, Weijun, Zhang, Zhixiang, Kang, Ya'an, Wang, Huamin, Fleming, Jason B., Pasche, Boris C., Zhang, Wei

“…Tumor-associated macrophages (TAMs) represent the M2-like phenotype with potent immunosuppressive activity, and play a pro-tumor role in pancreatic ductal…”
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Regorafenib dose-optimisation in patients with refractory metastatic colorectal cancer (ReDOS): a randomised, multicentre, open-label, phase 2 study by Bekaii-Saab, Tanios S, Prof, Ou, Fang-Shu, PhD, Ahn, Daniel H, DO, Boland, Patrick M, MD, Ciombor, Kristen K, MD, Heying, Erica N, BS, Dockter, Travis J, MS, Jacobs, Nisha L, MD, Pasche, Boris C, Prof, Cleary, James M, MD, Meyers, Jeffrey P, BS, Desnoyers, Rodwige J, MD, McCune, Jeannine S, Prof, Pedersen, Katrina, MD, Barzi, Afsaneh, MD, Chiorean, E Gabriela, Prof, Sloan, Jeffrey, Prof, Lacouture, Mario E, Prof, Lenz, Heinz-Josef, Prof, Grothey, Axel, MD

“…SummaryBackgroundRegorafenib confers an overall survival benefit in patients with refractory metastatic colorectal cancer; however, the adverse event profile…”
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Truncated Glioma-Associated Oncogene Homolog 1 (tGLI1) Mediates Mesenchymal Glioblastoma via Transcriptional Activation of CD44 by Rimkus, Tadas K, Carpenter, Richard L, Sirkisoon, Sherona, Zhu, Dongqin, Pasche, Boris C, Chan, Michael D, Lesser, Glenn J, Tatter, Stephen B, Watabe, Kounosuke, Debinski, Waldemar, Lo, Hui-Wen

“…The molecular pathways driving mesenchymal glioblastoma (GBM) are still not well understood. We report here that truncated glioma-associated oncogene homolog 1…”
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Combined inhibition of AKT and HSF1 suppresses breast cancer stem cells and tumor growth by Carpenter, Richard L, Sirkisoon, Sherona, Zhu, Dongqin, Rimkus, Tadas, Harrison, Alexandria, Anderson, Ashley, Paw, Ivy, Qasem, Shadi, Xing, Fei, Liu, Yin, Chan, Michael, Metheny-Barlow, Linda, Pasche, Boris C, Debinski, Waldemar, Watabe, Kounosuke, Lo, Hui-Wen

“…Breast cancer is the most common cancer in women and the second leading cause of cancer deaths in women. Over 90% of breast cancer deaths are attributable to…”
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Adaptation of a Personalized Electronic Care Planning Tool for Cancer Follow-up Care: Formative Study by Sohl, Stephanie J, Duncan, Pamela W, Thakur, Elyse, Puccinelli-Ortega, Nicole, Salsman, John M, Russell, Greg, Pasche, Boris C, Wentworth, Stacy, Miller, Jr, David P, Wagner, Lynne I, Topaloglu, Umit

“…Most patients diagnosed with colorectal cancer will survive for at least 5 years; thus, engaging patients to optimize their health will likely improve…”
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Loss of XIST in Breast Cancer Activates MSN-c-Met and Reprograms Microglia via Exosomal miRNA to Promote Brain Metastasis by Xing, Fei, Liu, Yin, Wu, Shih-Ying, Wu, Kerui, Sharma, Sambad, Mo, Yin-Yuan, Feng, Jiamei, Sanders, Stephanie, Jin, Guangxu, Singh, Ravi, Vidi, Pierre-Alexandre, Tyagi, Abhishek, Chan, Michael D, Ruiz, Jimmy, Debinski, Waldemar, Pasche, Boris C, Lo, Hui-Wen, Metheny-Barlow, Linda J, D'Agostino, Jr, Ralph B, Watabe, Kounosuke

“…Up to 30% of patients with metastatic breast cancer eventually develop brain metastasis, yet the pathologic mechanism behind this development remains poorly…”
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TGFβ in Pancreas and Colorectal Cancer: Opportunities to Overcome Therapeutic Resistance by Johansen, Allan M, Forsythe, Steven D, McGrath, Callum T, Barker, Grayson, Jimenez, Hugo, Paluri, Ravi K, Pasche, Boris C

“…TGFβ is a pleiotropic signaling pathway that plays a pivotal role in regulating a multitude of cellular functions. TGFβ has a dual role in cell regulation…”
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Recruitment of KMT2C/MLL3 to DNA Damage Sites Mediates DNA Damage Responses and Regulates PARP Inhibitor Sensitivity in Cancer by Chang, Antao, Liu, Liang, Ashby, Justin M, Wu, Dan, Chen, Yanan, O'Neill, Stacey S, Huang, Shan, Wang, Juan, Wang, Guanwen, Cheng, Dongmei, Tan, Xiaoming, Petty, W J, Pasche, Boris C, Xiang, Rong, Zhang, Wei, Sun, Peiqing

“…When recruited to promoters, histone 3 lysine 4 (H3K4) methyltransferases KMT2 (KMT2A-D) activate transcription by opening chromatin through H3K4 methylation…”
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Editor's Note: Truncated Glioma-Associated Oncogene Homolog 1 (tGLI1) Mediates Mesenchymal Glioblastoma via Transcriptional Activation of CD44 by Rimkus, Tadas K, Carpenter, Richard L, Sirkisoon, Sherona, Zhu, Dongqin, Pasche, Boris C, Chan, Michael D, Lesser, Glenn J, Tatter, Stephen B, Watabe, Kounosuke, Debinski, Waldemar, Lo, Hui-Wen

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RCC1 regulation of subcellular protein localization via Ran GTPase drives pancreatic ductal adenocarcinoma growth by Bannoura, Sahar F., Aboukameel, Amro, Khan, Husain Yar, Uddin, Md Hafiz, Jang, Hyejeong, Beal, Eliza W, Thangasamy, Amalraj, Shi, Yang, Kim, Seongho, Wagner, Kay-Uwe, Beydoun, Rafic, El-Rayes, Bassel F., Philip, Philip A., Mohammad, Ramzi M., Saif, Muhammad Wasif, Al-Hallak, Mohammed Najeeb, Pasche, Boris C., Azmi, Asfar S.

“…Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal malignancy, with limited therapeutic options. Here, we evaluated the role of regulator of chromosome…”
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Feasibility of Systems Support Mapping to guide patient-driven health self-management in colorectal cancer survivors by Sohl, Stephanie J., Befus, Deanna, Tooze, Janet A., Levine, Beverly, Golden, Shannon L., Puccinelli-Ortega, Nicole, Pasche, Boris C., Weaver, Kathryn E., Lich, Kristen Hassmiller

“…To evaluate feasibility of System Support Mapping (MAP), a systems thinking activity that involves creating a diagram of existing self-management activities…”
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Targeting guanine nucleotide exchange factors for novel cancer drug discovery by Bannoura, Sahar F, Khan, Husain Yar, Uddin, Md Hafiz, Mohammad, Ramzi M, Pasche, Boris C, Azmi, Asfar S

“…Guanine nucleotide exchange factors (GEFs) regulate the activation of small GTPases (G proteins) of the Ras superfamily proteins controlling cellular…”
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Improved Antitumor Activity of the Fluoropyrimidine Polymer CF10 in Preclinical Colorectal Cancer Models through Distinct Mechanistic and Pharmacologic Properties by Gmeiner, William H, Dominijanni, Anthony, Haber, Alex O, Ghiraldeli, Lais P, Caudell, David L, D'Agostino, Jr, Ralph, Pasche, Boris C, Smith, Thomas L, Deng, Zhiyong, Kiren, Sezgin, Mani, Chinnadurai, Palle, Komaraiah, Brody, Jonathan R

“…Chemotherapy regimens that include 5-fluorouracil (5-FU) are central to colorectal cancer treatment; however, risk/benefit concerns limit 5-FU's use,…”
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Oncology Navigation Decreases Time to Treatment in Patients with Pancreatic Malignancy by Enomoto, Laura M., Fenstermaker, Joyce, Desnoyers, Rodwige J., Pasche, Boris C., Blackstock, A. William, Howerton, Russell M., Clark, Clancy J., Levine, Edward A., Shen, Perry

“…Background Care of pancreatic cancer patients has become increasingly complex, which has led to delays in the initiation of therapy. Nurse navigators have been…”
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Correction: Loss of XIST in Breast Cancer Activates MSN-c-Met and Reprograms Microglia via Exosomal miRNA to Promote Brain Metastasis by Xing, Fei, Liu, Yin, Wu, Shih-Ying, Wu, Kerui, Sharma, Sambad, Mo, Yin-Yuan, Feng, Jiamei, Sanders, Stephanie, Jin, Guangxu, Singh, Ravi, Vidi, Pierre-Alexandre, Tyagi, Abhishek, Chan, Michael D., Ruiz, Jimmy, Debinski, Waldemar, Pasche, Boris C., Lo, Hui-Wen, Metheny-Barlow, Linda J., D'Agostino, Ralph B., Watabe, Kounosuke

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hDirect-MAP: projection-free single-cell modeling of response to checkpoint immunotherapy by Lu, Yong, Xue, Gang, Zheng, Ningbo, Han, Kun, Yang, Wenzhong, Wang, Rui-Sheng, Wu, Lingyun, Miller, Lance D, Pardee, Timothy, Triozzi, Pierre L, Lo, Hui-Wen, Watabe, Kounosuke, Wong, Stephen T C, Pasche, Boris C, Zhang, Wei, Jin, Guangxu

“…Abstract There is a lack of robust generalizable predictive biomarkers of response to immune checkpoint blockade in multiple types of cancer. We develop…”
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A transformer-based deep-learning approach for classifying brain metastases into primary organ sites using clinical whole-brain MRI images by Lyu, Qing, Namjoshi, Sanjeev V., McTyre, Emory, Topaloglu, Umit, Barcus, Richard, Chan, Michael D., Cramer, Christina K., Debinski, Waldemar, Gurcan, Metin N., Lesser, Glenn J., Lin, Hui-Kuan, Munden, Reginald F., Pasche, Boris C., Sai, Kiran K.S., Strowd, Roy E., Tatter, Stephen B., Watabe, Kounosuke, Zhang, Wei, Wang, Ge, Whitlow, Christopher T.

“…Treatment decisions for brain metastatic disease rely on knowledge of the primary organ site and are currently made with biopsy and histology. Here, we develop…”
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Tumour-specific amplitude-modulated radiofrequency electromagnetic fields induce differentiation of hepatocellular carcinoma via targeting Cav3.2 T-type voltage-gated calcium channels and Ca2+ influx by Jimenez, Hugo, Wang, Minghui, Zimmerman, Jacquelyn W., Pennison, Michael J., Sharma, Sambad, Surratt, Trevor, Xu, Zhi-Xiang, Brezovich, Ivan, Absher, Devin, Myers, Richard M., DeYoung, Barry, Caudell, David L., Chen, Dongquan, Lo, Hui-Wen, Lin, Hui-Kuan, Godwin, Dwayne W., Olivier, Michael, Ghanekar, Anand, Chen, Kui, Miller, Lance D., Gong, Yijian, Capstick, Myles, D'Agostino, Ralph B., Munden, Reginald, Merle, Philippe, Barbault, Alexandre, Blackstock, Arthur W., Bonkovsky, Herbert L., Yang, Guang-Yu, Jin, Guangxu, Liu, Liang, Zhang, Wei, Watabe, Kounosuke, Blackman, Carl F., Pasche, Boris C.

“…Administration of amplitude modulated 27·12 MHz radiofrequency electromagnetic fields (AM RF EMF) by means of a spoon-shaped applicator placed on the patient's…”
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Abstract 116: IGFBP2 promotes tumor progression by inducing alternative polarization of macrophages in pancreatic ductal adenocarcinoma by Sun, Longhao, Liu, Liang, Tian, Weijun, Zhang, Zhixiang, Kang, Ya'an, Wang, Huamin, Fleming, Jason B., Pasche, Boris C., Zhang, Wei

“…Abstract Pancreatic ductal adenocarcinoma (PDAC) is the most lethal and aggressive malignancy. Tumor-associated macrophages (TAMs) mainly represent the M2-like…”
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