Search Results - "Paschalis, P."

Advanced Glycation Endproducts and Bone Material Properties in Type 1 Diabetic Mice by Rubin, Mishaela R, Paschalis, Eleftherios P, Poundarik, Atharva, Sroga, Gyna E, McMahon, Donald J, Gamsjaeger, Sonja, Klaushofer, Klaus, Vashishth, Deepak

“…Fractures, particularly at the lower extremities and hip, are a complication of diabetes. In both type 1 (T1D) and type 2 diabetes (T2D), fracture risk is…”
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Bone mineralization density distribution in health and disease by Roschger, P, Paschalis, E.P, Fratzl, P, Klaushofer, K

“…Abstract Human cortical and trabecular bones are formed by individual osteons and bone packets, respectively, which are produced at different time points…”
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Raman analysis of proteoglycans simultaneously in bone and cartilage by Gamsjaeger, Sonja, Klaushofer, Klaus, Paschalis, Eleftherios P.

“…Bone and cartilage are connective tissues with distinct organic matrix (collagen and non‐collagenous proteins) composition facilitating their biological…”
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Vitamin C epigenetically controls osteogenesis and bone mineralization by Thaler, Roman, Khani, Farzaneh, Sturmlechner, Ines, Dehghani, Sharareh S., Denbeigh, Janet M., Zhou, Xianhu, Pichurin, Oksana, Dudakovic, Amel, Jerez, Sofia S., Zhong, Jian, Lee, Jeong-Heon, Natarajan, Ramesh, Kalajzic, Ivo, Jiang, Yong-hui, Deyle, David R., Paschalis, Eleftherios P., Misof, Barbara M., Ordog, Tamas, van Wijnen, Andre J.

“…Vitamin C deficiency disrupts the integrity of connective tissues including bone. For decades this function has been primarily attributed to Vitamin C as a…”
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Solar cycle variation of the ionization by cosmic rays in the atmosphere at the mid-latitude region of Athens by Makrantoni, P., Mavromichalaki, H., Paschalis, P.

“…In this study, the ionization rate in the atmosphere induced by solar and galactic cosmic rays is calculated for the region of Athens (Greece) during the time…”
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Homocysteine Suppresses the Expression of the Collagen Cross-linker Lysyl Oxidase Involving IL-6, Fli1, and Epigenetic DNA Methylation by Thaler, Roman, Agsten, Marlies, Spitzer, Silvia, Paschalis, Eleftherios P., Karlic, Heidrun, Klaushofer, Klaus, Varga, Franz

“…Elevated homocysteine (Hcys) serum levels represent a risk factor for several chronic pathologies, including cardiovascular disease, atherosclerosis, and…”
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Interplay between mineral crystallinity and mineral accumulation in health and postmenopausal osteoporosis by Gamsjaeger, S., Fratzl, P., Paschalis, E.P.

“…Osteoporosis is characterized by an imbalance between bone formation and resorption rates, resulting in bone loss. For ethical reasons, effects of…”
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Bone Fragility and Collagen Cross‐Links by Paschalis, Eleftherios P, Shane, Elizabeth, Lyritis, George, Skarantavos, Grigoris, Mendelsohn, Richard, Boskey, Adele L

“…Infrared imaging analysis of iliac crest biopsy specimens from patients with osteoporotic and multiple spontaneous fractures shows significant differences in…”
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Spectroscopic characterization of collagen cross-links in bone by Paschalis, E. P., Verdelis, K., Doty, S. B., Boskey, A. L., Mendelsohn, R., Yamauchi, M.

“…Collagen is the most abundant protein of the organic matrix in mineralizing tissues. One of its most critical properties is its cross-linking pattern. The…”
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Fourier Transform Infrared Spectroscopic Characterization of Mineralizing Type I Collagen Enzymatic Trivalent Cross-Links by Paschalis, E. P., Gamsjaeger, S., Tatakis, D. N., Hassler, N., Robins, S. P., Klaushofer, K.

“…The most abundant protein of bone’s organic matrix is collagen. One of its most important properties is its cross-linking pattern, which is responsible for the…”
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The First Ground-Level Enhancement of Solar Cycle 24 on 17 May 2012 and Its Real-Time Detection by Papaioannou, A., Souvatzoglou, G., Paschalis, P., Gerontidou, M., Mavromichalaki, H.

“…Ground-level enhancements (GLEs) are defined as sudden increases in the recorded intensity of cosmic-ray particles, usually by neutron monitors (NMs). In this…”
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Sclerostin Deficiency Is Linked to Altered Bone Composition by Hassler, Norbert, Roschger, Andreas, Gamsjaeger, Sonja, Kramer, Ina, Lueger, Sonja, van Lierop, Antoon, Roschger, Paul, Klaushofer, Klaus, Paschalis, Eleftherios P, Kneissel, Michaela, Papapoulos, Socrates

“…ABSTRACT High bone mass in animals and humans with sclerostin deficiency is associated with increased bone strength, which is not the case for all disorders…”
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Complementary information on in vitro conversion of amorphous (precursor) calcium phosphate to hydroxyapatite from Raman microspectroscopy and wide-angle X-ray scattering by Kazanci, M, Fratzl, P, Klaushofer, K, Paschalis, E P

“…In addition to mechanical functions, bones have an essential role in metabolic activity as mineral reservoirs that are able to absorb and release ions…”
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Bone material properties in premenopausal women with idiopathic osteoporosis by Misof, Barbara M, Gamsjaeger, Sonja, Cohen, Adi, Hofstetter, Birgit, Roschger, Paul, Stein, Emily, Nickolas, Thomas L, Rogers, Halley F, Dempster, David, Zhou, Hua, Recker, Robert, Lappe, Joan, McMahon, Donald, Paschalis, Eleftherios P, Fratzl, Peter, Shane, Elizabeth, Klaushofer, Klaus

“…Idiopathic osteoporosis (IOP) in premenopausal women is characterized by fragility fractures at low or normal bone mineral density (BMD) in otherwise healthy…”
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Phenotypic Spectrum in Osteogenesis Imperfecta Due to Mutations in TMEM38B: Unraveling a Complex Cellular Defect by Webb, Emma A., Balasubramanian, Meena, Fratzl-Zelman, Nadja, Cabral, Wayne A., Titheradge, Hannah, Alsaedi, Atif, Saraff, Vrinda, Vogt, Julie, Cole, Trevor, Stewart, Susan, Crabtree, Nicola J., Sargent, Brandi M., Gamsjaeger, Sonja, Paschalis, Eleftherios P., Roschger, Paul, Klaushofer, Klaus, Shaw, Nick J., Marini, Joan C., Högler, Wolfgang

“…Abstract Context: Recessive mutations in TMEM38B cause type XIV osteogenesis imperfecta (OI) by dysregulating intracellular calcium flux. Objectives: Clinical…”
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Cortical bone composition and orientation as a function of animal and tissue age in mice by Raman spectroscopy by Gamsjaeger, Sonja, Masic, A, Roschger, P, Kazanci, M, Dunlop, J.W.C, Klaushofer, K, Paschalis, E.P, Fratzl, P

“…Abstract Important aspects of bone tissue quality include the physicochemical properties of its main constituents, the organic matrix and the mineral crystals…”
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Fourier transform infrared analysis and bone by Paschalis, E. P

“…In a paper presented at the Third Meeting on Bone Quality, Jun 2008, Paschalis discussed Fourier transform infrared analysis and bone. FTIR microspectroscopy…”
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Optimization of neutron monitor data correction algorithms by Paschalis, P., Mavromichalaki, H.

“…Nowadays, several neutron monitor stations worldwide, broadcast their cosmic ray data in real time, in order for the scientific community to be able to use…”
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Bone material properties in actively bone‐forming trabeculae in postmenopausal women with osteoporosis after three years of treatment with once‐yearly Zoledronic acid by Gamsjaeger, Sonja, Buchinger, Birgit, Zwettler, Elizabeth, Recker, Robert, Black, Dennis, Gasser, Juerg A, Eriksen, Erik F, Klaushofer, Klaus, Paschalis, Eleftherios P

“…Zoledronic acid (ZOL), a third‐generation aminobisphosphonate, showed pronounced antifracture efficacy in a phase III clinical trial [Health Outcomes and…”
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Pediatric reference Raman data for material characteristics of iliac trabecular bone by Gamsjaeger, S, Hofstetter, B, Fratzl-Zelman, N, Roschger, P, Roschger, A, Fratzl, P, Brozek, W, Masic, A, Misof, B.M, Glorieux, F.H, Klaushofer, K, Rauch, F, Paschalis, E.P

“…Abstract Bone material characteristics are important contributors in the determination of bone strength. Raman spectroscopic analysis provides information on…”
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