Search Results - "Paschalis, Alec"

Prostate-specific Membrane Antigen Heterogeneity and DNA Repair Defects in Prostate Cancer by Paschalis, Alec, Sheehan, Beshara, Riisnaes, Ruth, Rodrigues, Daniel Nava, Gurel, Bora, Bertan, Claudia, Ferreira, Ana, Lambros, Maryou B.K., Seed, George, Yuan, Wei, Dolling, David, Welti, Jon C., Neeb, Antje, Sumanasuriya, Semini, Rescigno, Pasquale, Bianchini, Diletta, Tunariu, Nina, Carreira, Suzanne, Sharp, Adam, Oyen, Wim, de Bono, Johann S.

“…Prostate-specific membrane antigen (PSMA; folate hydrolase) prostate cancer (PC) expression has theranostic utility. To elucidate PC PSMA expression and…”
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Targeting Bromodomain and Extra-Terminal (BET) Family Proteins in Castration-Resistant Prostate Cancer (CRPC) by Welti, Jonathan, Sharp, Adam, Yuan, Wei, Dolling, David, Nava Rodrigues, Daniel, Figueiredo, Ines, Gil, Veronica, Neeb, Antje, Clarke, Matthew, Seed, George, Crespo, Mateus, Sumanasuriya, Semini, Ning, Jian, Knight, Eleanor, Francis, Jeffrey C, Hughes, Ashley, Halsey, Wendy S, Paschalis, Alec, Mani, Ram S, Raj, Ganesh V, Plymate, Stephen R, Carreira, Suzanne, Boysen, Gunther, Chinnaiyan, Arul M, Swain, Amanda, de Bono, Johann S

“…Persistent androgen receptor (AR) signaling drives castration-resistant prostate cancer (CRPC) and confers resistance to AR-targeting therapies. Novel…”
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Characterizing CDK12-Mutated Prostate Cancers by Rescigno, Pasquale, Gurel, Bora, Pereira, Rita, Crespo, Mateus, Rekowski, Jan, Rediti, Mattia, Barrero, Maialen, Mateo, Joaquin, Bianchini, Diletta, Messina, Carlo, Fenor de la Maza, Maria D, Chandran, Khobe, Carmichael, Juliet, Guo, Christina, Paschalis, Alec, Sharp, Adam, Seed, George, Figueiredo, Ines, Lambros, Maryou, Miranda, Susana, Ferreira, Ana, Bertan, Claudia, Riisnaes, Ruth, Porta, Nuria, Yuan, Wei, Carreira, Suzanne, de Bono, Johann S

“…Cyclin-dependent kinase 12 (CDK12) aberrations have been reported as a biomarker of response to immunotherapy for metastatic castration-resistant prostate…”
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HER3 Is an Actionable Target in Advanced Prostate Cancer by Gil, Veronica, Miranda, Susana, Riisnaes, Ruth, Gurel, Bora, D'Ambrosio, Mariantonietta, Vasciaveo, Alessandro, Crespo, Mateus, Ferreira, Ana, Brina, Daniela, Troiani, Martina, Sharp, Adam, Sheehan, Beshara, Christova, Rossitza, Seed, George, Figueiredo, Ines, Lambros, Maryou, Dolling, David, Rekowski, Jan, Alajati, Abdullah, Clarke, Matthew, Pereira, Rita, Flohr, Penny, Fowler, Gemma, Boysen, Gunther, Sumanasuriya, Semini, Bianchini, Diletta, Rescigno, Pasquale, Aversa, Caterina, Tunariu, Nina, Guo, Christina, Paschalis, Alec, Bertan, Claudia, Buroni, Lorenzo, Ning, Jian, Carreira, Suzanne, Workman, Paul, Swain, Amanda, Califano, Andrea, Shen, Michael M, Alimonti, Andrea, Neeb, Antje, Welti, Jonathan, Yuan, Wei, de Bono, Johann

“…It has been recognized for decades that ERBB signaling is important in prostate cancer, but targeting ERBB receptors as a therapeutic strategy for prostate…”
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RB/E2F1 as a Master Regulator of Cancer Cell Metabolism in Advanced Disease by Mandigo, Amy C, Yuan, Wei, Xu, Kexin, Gallagher, Peter, Pang, Angel, Guan, Yi Fang, Shafi, Ayesha A, Thangavel, Chellappagounder, Sheehan, Beshara, Bogdan, Denisa, Paschalis, Alec, McCann, Jennifer J, Laufer, Talya S, Gordon, Nicolas, Vasilevskaya, Irina A, Dylgjeri, Emanuela, Chand, Saswati N, Schiewer, Matthew J, Domingo-Domenech, Josep, Den, Robert B, Holst, Jeff, McCue, Peter A, de Bono, Johann S, McNair, Christopher, Knudsen, Karen E

“…Loss of the retinoblastoma (RB) tumor suppressor protein is a critical step in reprogramming biological networks that drive cancer progression, although…”
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The catalytic subunit of DNA-PK regulates transcription and splicing of AR in advanced prostate cancer by Adamson, Beth, Brittain, Nicholas, Walker, Laura, Duncan, Ruaridh, Luzzi, Sara, Rescigno, Pasquale, Smith, Graham, McGill, Suzanne, Burchmore, Richard Js, Willmore, Elaine, Hickson, Ian, Robson, Craig N, Bogdan, Denisa, Jimenez-Vacas, Juan M, Paschalis, Alec, Welti, Jonathan, Yuan, Wei, McCracken, Stuart R, Heer, Rakesh, Sharp, Adam, de Bono, Johann S, Gaughan, Luke

“…Aberrant androgen receptor (AR) signaling drives prostate cancer (PC), and it is a key therapeutic target. Although initially effective, the generation of…”
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β1-Adrenoceptor distribution in the rat brain: An immunohistochemical study by PASCHALIS, Alec, CHURCHILL, Linda, MARINA, Nephtali, KASYMOV, Vitaliy, GOURINE, Alexander, ACKLAND, Gareth

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Prostate Cancer 2020: “The Times They Are a’Changing” by Paschalis, Alec, de Bono, Johann S.

“…Prostate cancer (PC) care is rapidly evolving, with improved treatment options and outcomes. Trials recently published in the New England Journal of Medicine…”
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A New Old Target: Androgen Receptor Signaling and Advanced Prostate Cancer by Westaby, Daniel, Fenor de La Maza, Maria de Los Dolores, Paschalis, Alec, Jimenez-Vacas, Juan M, Welti, Jon, de Bono, Johann, Sharp, Adam

“…Owing to the development of multiple novel therapies, there has been major progress in the treatment of advanced prostate cancer over the last two decades;…”
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Alternative splicing in prostate cancer by Paschalis, Alec, Sharp, Adam, Welti, Jonathan C., Neeb, Antje, Raj, Ganesh V., Luo, Jun, Plymate, Stephen R., de Bono, Johann. S.

“…Androgen receptor (AR) splice variants (AR-Vs) have been implicated in the development and progression of metastatic prostate cancer. AR-Vs are truncated…”
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Biomarkers Associating with PARP Inhibitor Benefit in Prostate Cancer in the TOPARP-B Trial by Carreira, Suzanne, Porta, Nuria, Arce-Gallego, Sara, Seed, George, Llop-Guevara, Alba, Bianchini, Diletta, Rescigno, Pasquale, Paschalis, Alec, Bertan, Claudia, Baker, Chloe, Goodall, Jane, Miranda, Susana, Riisnaes, Ruth, Figueiredo, Ines, Ferreira, Ana, Pereira, Rita, Crespo, Mateus, Gurel, Bora, Nava Rodrigues, Daniel, Pettitt, Stephen J, Yuan, Wei, Serra, Violeta, Rekowski, Jan, Lord, Christopher J, Hall, Emma, Mateo, Joaquin, de Bono, Johann S

“…PARP inhibitors are approved for treating advanced prostate cancers (APC) with various defective DNA repair genes; however, further studies to clinically…”
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Advanced Prostate Cancer with ATM Loss: PARP and ATR Inhibitors by Neeb, Antje, Herranz, Nicolás, Arce-Gallego, Sara, Miranda, Susana, Buroni, Lorenzo, Yuan, Wei, Athie, Alejandro, Casals, Teresa, Carmichael, Juliet, Rodrigues, Daniel Nava, Gurel, Bora, Rescigno, Pasquale, Rekowski, Jan, Welti, Jon, Riisnaes, Ruth, Gil, Veronica, Ning, Jian, Wagner, Verena, Casanova-Salas, Irene, Cordoba, Sarai, Castro, Natalia, Fenor de la Maza, Maria Dolores, Seed, George, Chandran, Khobe, Ferreira, Ana, Figueiredo, Ines, Bertan, Claudia, Bianchini, Diletta, Aversa, Caterina, Paschalis, Alec, Gonzalez, Macarena, Morales-Barrera, Rafael, Suarez, Cristina, Carles, Joan, Swain, Amanda, Sharp, Adam, Gil, Jesus, Serra, Violeta, Lord, Christopher, Carreira, Suzanne, Mateo, Joaquin, de Bono, Johann S.

“…Deleterious ATM alterations are found in metastatic prostate cancer (PC); PARP inhibition has antitumour activity against this subset, but only some ATM loss…”
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Genomic Analysis of Three Metastatic Prostate Cancer Patients with Exceptional Responses to Carboplatin Indicating Different Types of DNA Repair Deficiency by Zafeiriou, Zafeiris, Bianchini, Diletta, Chandler, Robert, Rescigno, Pasquale, Yuan, Wei, Carreira, Suzanne, Barrero, Maialen, Petremolo, Antonella, Miranda, Susana, Riisnaes, Ruth, Rodrigues, Daniel Nava, Gurel, Bora, Sumanasuriya, Semini, Paschalis, Alec, Sharp, Adam, Mateo, Joaquin, Tunariu, Nina, Chinnaiyan, Arul M., Pritchard, Colin C., Kelly, Kevin, de Bono, Johann S.

“…Platinum-based regimens have not been proved to increase survival from advanced prostate cancer (PCa). Incontrovertible evidence that a proportion of prostate…”
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Prostate-specific Membrane Antigen Biology in Lethal Prostate Cancer and its Therapeutic Implications by Sheehan, Beshara, Guo, Christina, Neeb, Antje, Paschalis, Alec, Sandhu, Shahneen, de Bono, Johann S

“…Prostate-specific membrane antigen (PSMA) is a promising, novel theranostic target in advanced prostate cancer (PCa). Multiple PSMA-targeted therapies are…”
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Prostate-Specific Membrane Antigen Expression and Response to DNA Damaging Agents in Prostate Cancer by Sheehan, Beshara, Neeb, Antje, Buroni, Lorenzo, Paschalis, Alec, Riisnaes, Ruth, Gurel, Bora, Gil, Veronica, Miranda, Susana, Crespo, Mateus, Guo, Christina, Jiménez Vacas, Juan, Figueiredo, Ines, Ferreira, Ana, Welti, Jon, Yuan, Wei, Carreira, Suzanne, Sharp, Adam, de Bono, Johann

“…Prostate-specific membrane antigen (PSMA) targeting therapies such as Lutetium-177 (177Lu)-PSMA-617 are affecting outcomes from metastatic castration-resistant…”
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Clinical Utility of Circulating Tumour Cell Androgen Receptor Splice Variant-7 Status in Metastatic Castration-resistant Prostate Cancer by Sharp, Adam, Welti, Jon C., Lambros, Maryou B.K., Dolling, David, Rodrigues, Daniel Nava, Pope, Lorna, Aversa, Caterina, Figueiredo, Ines, Fraser, Jennifer, Ahmad, Zai, Lu, Changxue, Rescigno, Pasquale, Kolinsky, Michael, Bertan, Claudia, Seed, George, Riisnaes, Ruth, Miranda, Susana, Crespo, Mateus, Pereira, Rita, Ferreira, Ana, Fowler, Gemma, Ebbs, Berni, Flohr, Penny, Neeb, Antje, Bianchini, Diletta, Petremolo, Antonella, Sumanasuriya, Semini, Paschalis, Alec, Mateo, Joaquin, Tunariu, Nina, Yuan, Wei, Carreira, Suzanne, Plymate, Stephen R., Luo, Jun, de Bono, Johann S.

“…Detection of androgen receptor splice variant-7 (AR-V7) mRNA in circulating tumour cells (CTCs) is associated with worse outcome in metastatic…”
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The landscape of RNA polymerase II-associated chromatin interactions in prostate cancer by Ramanand, Susmita G, Chen, Yong, Yuan, Jiapei, Daescu, Kelly, Lambros, Maryou Bk, Houlahan, Kathleen E, Carreira, Suzanne, Yuan, Wei, Baek, GuemHee, Sharp, Adam, Paschalis, Alec, Kanchwala, Mohammed, Gao, Yunpeng, Aslam, Adam, Safdar, Nida, Zhan, Xiaowei, Raj, Ganesh V, Xing, Chao, Boutros, Paul C, de Bono, Johann, Zhang, Michael Q, Mani, Ram S

“…Transcriptional dysregulation is a hallmark of prostate cancer (PCa). We mapped the RNA polymerase II-associated (RNA Pol II-associated) chromatin interactions…”
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Critical role of antioxidant programs in enzalutamide-resistant prostate cancer by Blatt, Eliot B., Parra, Karla, Neeb, Antje, Buroni, Lorenzo, Bogdan, Denisa, Yuan, Wei, Gao, Yunpeng, Gilbreath, Collin, Paschalis, Alec, Carreira, Suzanne, DeBerardinis, Ralph J., Mani, Ram S., de Bono, Johann S., Raj, Ganesh V.

“…Therapy resistance to second-generation androgen receptor (AR) antagonists, such as enzalutamide, is common in patients with advanced prostate cancer (PCa). To…”
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Targeting myeloid chemotaxis to reverse prostate cancer therapy resistance by Guo, Christina, Sharp, Adam, Gurel, Bora, Crespo, Mateus, Figueiredo, Ines, Jain, Suneil, Vogl, Ursula, Rekowski, Jan, Rouhifard, Mahtab, Gallagher, Lewis, Yuan, Wei, Carreira, Suzanne, Chandran, Khobe, Paschalis, Alec, Colombo, Ilaria, Stathis, Anastasios, Bertan, Claudia, Seed, George, Goodall, Jane, Raynaud, Florence, Ruddle, Ruth, Swales, Karen E., Malia, Jason, Bogdan, Denisa, Tiu, Crescens, Caldwell, Reece, Aversa, Caterina, Ferreira, Ana, Neeb, Antje, Tunariu, Nina, Westaby, Daniel, Carmichael, Juliet, Fenor de la Maza, Maria Dolores, Yap, Christina, Matthews, Ruth, Badham, Hannah, Prout, Toby, Turner, Alison, Parmar, Mona, Tovey, Holly, Riisnaes, Ruth, Flohr, Penny, Gil, Jesus, Waugh, David, Decordova, Shaun, Schlag, Anna, Calì, Bianca, Alimonti, Andrea, de Bono, Johann S.

“…Inflammation is a hallmark of cancer 1 . In patients with cancer, peripheral blood myeloid expansion, indicated by a high neutrophil-to-lymphocyte ratio,…”
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A Transgender Patient with Prostate Cancer: Lessons Learnt by Chandran, Khobe, Grochot, Rafael, de Los Dolores Fenor De La Maza, Maria, Yuan, Wei, Gurel, Bora, Miranda, Susana, Paschalis, Alec, Riisnaes, Ruth, Figueiredo, Ines, Bogdan, Denisa, Sharp, Adam, Carreira, Suzanne, de Bono, Johann S.

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