Search Results - "Pascale Bossard"

Lkb1 suppresses amino acid-driven gluconeogenesis in the liver by Just, Pierre-Alexandre, Charawi, Sara, Denis, Raphaël G. P., Savall, Mathilde, Traore, Massiré, Foretz, Marc, Bastu, Sultan, Magassa, Salimata, Senni, Nadia, Sohier, Pierre, Wursmer, Maud, Vasseur-Cognet, Mireille, Schmitt, Alain, Le Gall, Morgane, Leduc, Marjorie, Guillonneau, François, De Bandt, Jean-Pascal, Mayeux, Patrick, Romagnolo, Béatrice, Luquet, Serge, Bossard, Pascale, Perret, Christine

“…Excessive glucose production by the liver is a key factor in the hyperglycemia observed in type 2 diabetes mellitus (T2DM). Here, we highlight a novel role of…”
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SREBP transcription factors: master regulators of lipid homeostasis by Eberlé, Delphine, Hegarty, Bronwyn, Bossard, Pascale, Ferré, Pascal, Foufelle, Fabienne

“…Sterol regulatory element binding proteins (SREBPs) are a family of transcription factors that regulate lipid homeostasis by controlling the expression of a…”
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Hepatocellular Carcinomas With Mutational Activation of Beta-Catenin Require Choline and Can Be Detected by Positron Emission Tomography by Gougelet, Angélique, Sartor, Chiara, Senni, Nadia, Calderaro, Julien, Fartoux, Laetitia, Lequoy, Marie, Wendum, Dominique, Talbot, Jean-Noël, Prignon, Aurélie, Chalaye, Julia, Imbeaud, Sandrine, Zucman-Rossi, Jessica, Tordjmann, Thierry, Godard, Cécile, Bossard, Pascale, Rosmorduc, Olivier, Amaddeo, Giuliana, Colnot, Sabine

“…In one-third of hepatocellular carcinomas (HCCs), cancer cells have mutations that activate β-catenin pathway. These cells have alterations in glutamine, bile,…”
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Author Correction: Lkb1 suppresses amino acid-driven gluconeogenesis in the liver by Just, Pierre-Alexandre, Charawi, Sara, Denis, Raphaël G. P., Savall, Mathilde, Traore, Massiré, Foretz, Marc, Bastu, Sultan, Magassa, Salimata, Senni, Nadia, Sohier, Pierre, Wursmer, Maud, Vasseur-Cognet, Mireille, Schmitt, Alain, Le Gall, Morgane, Leduc, Marjorie, Guillonneau, François, De Bandt, Jean-Pascal, Mayeux, Patrick, Romagnolo, Béatrice, Luquet, Serge, Bossard, Pascale, Perret, Christine

“…A Correction to this paper has been published: https://doi.org/10.1038/s41467-021-22104-4…”
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Cooperation Between the NRF2 Pathway and Oncogenic β‐catenin During HCC Tumorigenesis by Savall, Mathilde, Senni, Nadia, Lagoutte, Isabelle, Sohier, Pierre, Dentin, Renaud, Romagnolo, Beatrice, Perret, Christine, Bossard, Pascale

“…CTNNB1 (catenin beta 1)–mutated hepatocellular carcinomas (HCCs) account for a large proportion of human HCCs. They display high levels of respiratory chain…”
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ARID1A loss in adult hepatocytes activates β-catenin-mediated erythropoietin transcription by Riou, Rozenn, Ladli, Meriem, Gerbal-Chaloin, Sabine, Bossard, Pascale, Gougelet, Angélique, Godard, Cécile, Loesch, Robin, Lagoutte, Isabelle, Lager, Franck, Calderaro, Julien, Dos Santos, Alexandre, Wang, Zhong, Verdier, Frédérique, Colnot, Sabine

“…Erythropoietin (EPO) is a key regulator of erythropoiesis. The embryonic liver is the main site of erythropoietin synthesis, after which the kidney takes over…”
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Hypothalamic ventromedial COUP-TFII protects against hypoglycemia-associated autonomic failure by Sabra-Makke, Lina, Maritan, Micol, Planchais, Julien, Boutant, Marie, Pégorier, Jean-Paul, Even, Patrick C., Vasseur-Cognet, Mireille, Bossard, Pascale

“…The nuclear receptor Chicken Ovalbumin Upstream Promoter–Transcription Factor II (COUP-TFII) is an important coordinator of glucose homeostasis through its…”
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GATA transcription factors as potentiators of gut endoderm differentiation by Bossard, P, Zaret, K S

“…Gene inactivation studies have shown that members of the GATA family of transcription factors are critical for endoderm differentiation in mice, flies and…”
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COUP-TFII controls mouse pancreatic β-cell mass through GLP-1-β-catenin signaling pathways by Boutant, Marie, Ramos, Oscar Henrique Pereira, Tourrel-Cuzin, Cécile, Movassat, Jamileh, Ilias, Anissa, Vallois, David, Planchais, Julien, Pégorier, Jean-Paul, Schuit, Frans, Petit, Patrice X, Bossard, Pascale, Maedler, Kathrin, Grapin-Botton, Anne, Vasseur-Cognet, Mireille

“…The control of the functional pancreatic β-cell mass serves the key homeostatic function of releasing the right amount of insulin to keep blood sugar in the…”
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The nutritional induction of COUP-TFII gene expression in ventromedial hypothalamic neurons is mediated by the melanocortin pathway by Sabra-Makke, Lina, Tourrel-Cuzin, Cécile, Denis, Raphaël G P, Moldes, Marthe, Pégorier, Jean-Paul, Luquet, Serge, Vasseur-Cognet, Mireille, Bossard, Pascale

“…The nuclear receptor chicken ovalbumin upstream promoter transcription factor II (COUP-TFII) is an important coordinator of glucose homeostasis. We report, for…”
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Differential Regulation of Sterol Regulatory Element-binding Protein 1c Transcriptional Activity by Insulin and Liver X Receptor during Liver Development by Bobard, Alexandre, Hainault, Isabelle, Ferré, Pascal, Foufelle, Fabienne, Bossard, Pascale

“…Sterol regulatory element-binding proteins (SREBPs) are transcription factors involved in the synthesis of cholesterol and fatty acids. In adults, the isoform…”
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Distinct roles of insulin and liver X receptor in the induction and cleavage of sterol regulatory elementbinding protein-1c by Hegarty, Bronwyn D., Bobard, Alexandre, Hainault, Isabelle, Ferré, Pascal, Bossard, Pascale, Foufelle, Fabienne

“…Sterol regulatory element-binding proteins (SREBPs) are transcription factors central to the regulation of lipid metabolism. The SREBPs are synthesized as…”
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AXIN deficiency in human and mouse hepatocytes induces hepatocellular carcinoma in the absence of β-catenin activation by Abitbol, Shirley, Dahmani, Rajae, Coulouarn, Cédric, Ragazzon, Bruno, Mlecnik, Bernhard, Senni, Nadia, Savall, Mathilde, Bossard, Pascale, Sohier, Pierre, Drouet, Valerie, Tournier, Emilie, Dumont, Florent, Sanson, Romain, Calderaro, Julien, Zucman-Rossi, Jessica, Vasseur-Cognet, Mireille, Just, Pierre-Alexandre, Terris, Benoît, Perret, Christine, Gilgenkrantz, Hélène

“…[Display omitted] •Most human AXIN1 mutated HCCs do not show a β-catenin activation program.•HCC induced by Axin1 deficiency in mice develop independently of…”
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ChREBP, but not LXRs, is required for the induction of glucose-regulated genes in mouse liver by Denechaud, Pierre-Damien, Bossard, Pascale, Lobaccaro, Jean-Marc A, Millatt, Lesley, Staels, Bart, Girard, Jean, Postic, Catherine

“…The transcription factor carbohydrate-responsive element-binding protein (ChREBP) has emerged as a central regulator of lipid synthesis in liver because it is…”
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Hepatocellular Carcinomas With Mutational Activation of Beta-Catenin Require Choline and Can Be Detected by Positron Emission Tomography by Gougelet, Angélique, Sartor, Chiara, Senni, Nadia, Calderaro, Julien, Fartoux, Laetitia, Lequoy, Marie, Wendum, Dominique, Talbot, Jean-Noël, Prignon, Aurelie, Chalaye, Julia, Imbeaud, Sandrine, Zucman-Rossi, Jessica, Tordjmann, Thierry, Godard, Cécile, Bossard, Pascale P., Rosmorduc, Olivier, Amaddeo, Giuliana, Colnot, Sabine

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Axin1 Protects Colon Carcinogenesis by an Immune-Mediated Effect by Sanson, Romain, Lazzara, Silvia Luna, Cune, David, Pitasi, Caterina Luana, Trentesaux, Coralie, Fraudeau, Marie, Letourneur, Franck, Saintpierre, Benjamin, Le Gall, Morgane, Bossard, Pascale, Terris, Benoit, Finetti, Pascal, Bertucci, François, Mamessier, Emilie, Romagnolo, Béatrice, Perret, Christine

“…Axin1 is a negative regulator of wingless-type MMTV integration site family, member 1 (Wnt)/β-catenin signaling with tumor-suppressor function. The Wnt pathway…”
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Lkb1 suppresses amino acid-driven gluconeogenesis in the liver. Correction by Just, Pierre-Alexandre, Charawi, Sara, Denis, Raphael G. P., Savall, Mathilde, Traore, Massire, Foretz, Marc, Bastu, Sultan, Magassa, Salimata, Senni, Nadia, Sohier, Pierre, Wursmer, Maud, Vasseur-Cognet, Mireille, Schmitt, Alain, Le Gall, Morgane, Leduc, Marjorie, Guillonneau, Francois, de Bandt, Jean-Pascal, Mayeux, Patrick, Romagnolo, Beatrice, Luquet, Serge, Bossard, Pascale, Perret, Christine

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Lkb1 suppresses amino acid-driven gluconeogenesis in the liver by Just, Pierre-Alexandre, Charawi, Sara, Denis, Raphaël, Savall, Mathilde, Traore, Massiré, Foretz, Marc, Bastu, Sultan, Magassa, Salimata, Senni, Nadia, Sohier, Pierre, Wursmer, Maud, Vasseur-Cognet, Mireille, Schmitt, Alain, Le Gall, Morgane, Leduc, Marjorie, Guillonneau, François, de Bandt, Jean-Pascal, Mayeux, Patrick, Romagnolo, Béatrice, Luquet, Serge, Bossard, Pascale, Perret, Christine

“…Abstract Excessive glucose production by the liver is a key factor in the hyperglycemia observed in type 2 diabetes mellitus (T2DM). Here, we highlight a novel…”
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Cooperation Between the NRF2 Pathway and Oncogenic β‐catenin During HCC Tumorigenesis by Bossard, Pascale, Savall, Mathilde, Senni, Nadia, Lagoutte, Isabelle, Sohier, Pierre, Dentin, Renaud, Romagnolo, Beatrice, Perret, Christine

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Cooperation Between the NRF2 Pathway and Oncogenic β‐catenin During HCC Tumorigenesis by Savall, Mathilde, Senni, Nadia, Lagoutte, Isabelle, Sohier, Pierre, Dentin, Renaud, Romagnolo, Beatrice, Perret, Christine, Bossard, Pascale

“…CTNNB1 (catenin beta 1)-mutated hepatocellular carcinomas (HCCs) account for a large proportion of human HCCs. They display high levels of respiratory chain…”
Get full text