Search Results - "Parvizi, Gregory"
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Two abundant proteasome subtypes that uniquely process some antigens presented by HLA class I molecules
Published in Proceedings of the National Academy of Sciences - PNAS (26-10-2010)“…Most antigenic peptides presented by MHC class I molecules result from the degradation of intracellular proteins by the proteasome. In lymphoid tissues and…”
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Silencing of cancer-germline genes in human preimplantation embryos: Evidence for active de novo DNA methylation in stem cells
Published in Biochemical and biophysical research communications (06-01-2012)“…► Human cancer-germline (CG) genes, including MAGEA1, become repressed in blastocysts. ► Embryonal carcinoma (EC) stem cells exert active repression of the…”
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DNA Methylation‐Associated Repression of Cancer‐Germline Genes in Human Embryonic and Adult Stem Cells
Published in Stem cells (Dayton, Ohio) (01-04-2009)“…Cancer‐germline (CG) genes are a particular group of germline‐specific genes that rely primarily on DNA methylation for repression in somatic tissues. In a…”
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Epigenetic hierarchy within the MAGEA1 cancer-germline gene: promoter DNA methylation dictates local histone modifications
Published in PloS one (05-03-2013)“…Gene MAGEA1 belongs to a group of human germline-specific genes that rely on DNA methylation for repression in somatic tissues. Many of these genes, termed…”
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The unexpected structure of the designed protein Octarellin V.1 forms a challenge for protein structure prediction tools
Published in Journal of structural biology (01-07-2016)“…Despite impressive successes in protein design, designing a well-folded protein of more 100 amino acids de novo remains a formidable challenge. Exploiting the…”
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Epigenetic Hierarchy within the MAGEA1 Cancer-Germline Gene: Promoter DNA Methylation Dictates Local Histone Modifications. e58743
Published in PloS one (01-03-2013)“…Gene MAGEA1 belongs to a group of human germline-specific genes that rely on DNA methylation for repression in somatic tissues. Many of these genes, termed…”
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Roles and interactions among protease-activated receptors and P2ry12 in hemostasis and thrombosis
Published in Proceedings of the National Academy of Sciences - PNAS (26-10-2010)“…Toward understanding their redundancies and interactions in hemostasis and thrombosis, we examined the roles of thrombin receptors (protease-activated…”
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