Oral Antihypertensive Regimens (Nifedipine-retard, Labetalol, and Methyldopa) for Management of Severe Hypertension in Pregnancy: An Open-Label, Randomized Controlled Trial

Oral Antihypertensive Regimens (Nifedipine-retard, Labetalol, and Methyldopa) for Management of Severe Hypertension in Pregnancy: An Open-Label, Randomized Controlled Trial

(Lancet. 2019;394:1011–1021) Hypertension complicates ∼10% of pregnancies, and is associated with adverse outcomes for the mother and child. Severe hypertension in pregnancy, defined as a systolic blood pressure ≥160 mm Hg or diastolic blood pressure ≥110mm Hg, is considered an obstetric emergency r...

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Bibliographic Details
Published in:Obstetric anesthesia digest Vol. 40; no. 3; pp. 150 - 151
Main Authors: Easterling, T., Mundle, S., Bracken, H., Parvekar, S., Mool, S., Magee, L.A., von Dadelszen, P., Shochet, T., Winikoff, B.
Format: Journal Article
Language:English
Published: Lippincott Williams & Wilkins 01-09-2020
Online Access:Get full text
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Summary:(Lancet. 2019;394:1011–1021) Hypertension complicates ∼10% of pregnancies, and is associated with adverse outcomes for the mother and child. Severe hypertension in pregnancy, defined as a systolic blood pressure ≥160 mm Hg or diastolic blood pressure ≥110mm Hg, is considered an obstetric emergency requiring urgent antihypertensive treatment to prevent cardiovascular or cerebrovascular events. There are currently insufficient data on medications used to treat severe hypertension in pregnancy. This study directly compared 3 oral drugs—labetalol, nifedipine, and methyldopa—for efficacy and safety when used for the treatment of severe hypertension in pregnancy.
ISSN:0275-665X
DOI:10.1097/01.aoa.0000693800.56482.14