Role of E-cadherin and β-catenin in head and neck squamous cell carcinoma

Aim of the study : to present and summarize current data on the prognostic value of E-cadherin and β-catenin markers for head and neck squamous cell carcinoma, as well as to substantiate the potential benefit from implementing research results into clinical practice within the framework of a persona...

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Bibliographic Details
Published in:	Sibirskiĭ onkologicheskiĭ zhurnal Vol. 22; no. 6; pp. 130 - 137
Main Authors:	Petrova, A. A., Samoylova, S. I., Magomedkerimova, L. V., Parts, S. A., Reshetov, I. V.
Format:	Journal Article
Language:	English Russian
Published:	Russian Academy of Sciences, Tomsk National Research Medical Center 03-01-2024
Subjects:	carcinoma e-cadherin epithelial-mesenchymal transition head and neck organs prognostic factor squamous cell carcinoma β-catenin
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Summary:	Aim of the study : to present and summarize current data on the prognostic value of E-cadherin and β-catenin markers for head and neck squamous cell carcinoma, as well as to substantiate the potential benefit from implementing research results into clinical practice within the framework of a personalized approach to the treatment of head and neck squamous cell carcinoma. Material and Methods . We performed a literature search and review in Pubmed, Scopus, Google Scholar and RSCI databases regarding the association of the level of E-cadherin and β-catenin markers with disease prognosis, aggressiveness of tumor behavior and response to treatment. Results . Detailed information on the functions and mechanisms of E-cadherin and β-catenin proteins were presented and pathogenetic pathways involved in epithelial-mesenchymal transition were described. The results of studies on the association of β-catenin and E-cadherin expression levels with the prognosis of head and neck squamous cell carcinoma are collected and summarized. High expression levels of β-catenin and E-cadherin are associated with lymph node metastasis, poor prognosis and poor response to treatment. Conclusion . The expression levels of β-catenin and E-cadherin correlate with tumor invasion and lymph node metastasis, thus suggesting that β-catenin and E-cadherin can be used as potential markers of prognosis and treatment response in patients with head and neck squamous cell carcinoma. Further studies are needed to evaluate the co-expression of E-cadherin, β-catenin and other squamous cell carcinoma-associated markers, their impact on prognosis and treatment response, as well as their prognostic value.
ISSN:	1814-4861 2312-3168
DOI:	10.21294/1814-4861-2023-22-6-130-137