Search Results - "Partridge, Janet F."

Histone H3 mutations—a special role for H3.3 in tumorigenesis? by Kallappagoudar, Satish, Yadav, Rajesh K., Lowe, Brandon R., Partridge, Janet F.

“…Brain tumors are the most common solid tumors in children. Pediatric high-grade glioma (HGG) accounts for ∼8–12 % of these brain tumors and is a devastating…”
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Characterization of Dicer-Deficient Murine Embryonic Stem Cells by Murchison, Elizabeth P, Partridge, Janet F, Tam, Oliver H, Cheloufi, Sihem, Hannon, Gregory J

“…Dicer is an RNase III-family nuclease that initiates RNA interference (RNAi) and related phenomena by generation of the small RNAs that determine the…”
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SHREC Silences Heterochromatin via Distinct Remodeling and Deacetylation Modules by Job, Godwin, Brugger, Christiane, Xu, Tao, Lowe, Brandon R., Pfister, Yvan, Qu, Chunxu, Shanker, Sreenath, Baños Sanz, José I., Partridge, Janet F., Schalch, Thomas

“…Nucleosome remodeling and deacetylation (NuRD) complexes are co-transcriptional regulators implicated in differentiation, development, and diseases. Methyl-CpG…”
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PHF6 cooperates with SWI/SNF complexes to facilitate transcriptional progression by Mittal, Priya, Myers, Jacquelyn A., Carter, Raymond D., Radko-Juettner, Sandi, Malone, Hayden A., Rosikiewicz, Wojciech, Robertson, Alexis N., Zhu, Zhexin, Narayanan, Ishwarya V., Hansen, Baranda S., Parrish, Meadow, Bhanu, Natarajan V., Mobley, Robert J., Rehg, Jerold E., Xu, Beisi, Drosos, Yiannis, Pruett-Miller, Shondra M., Ljungman, Mats, Garcia, Benjamin A., Wu, Gang, Partridge, Janet F., Roberts, Charles W. M.

“…Genes encoding subunits of SWI/SNF (BAF) chromatin remodeling complexes are mutated in nearly 25% of cancers. To gain insight into the mechanisms by which…”
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Surprising phenotypic diversity of cancer-associated mutations of Gly 34 in the histone H3 tail by Lowe, Brandon R, Yadav, Rajesh K, Henry, Ryan A, Schreiner, Patrick, Matsuda, Atsushi, Fernandez, Alfonso G, Finkelstein, David, Campbell, Margaret, Kallappagoudar, Satish, Jablonowski, Carolyn M, Andrews, Andrew J, Hiraoka, Yasushi, Partridge, Janet F

“…Sequencing of cancer genomes has identified recurrent somatic mutations in histones, termed oncohistones, which are frequently poorly understood. Previously we…”
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High-Affinity Binding of Chp1 Chromodomain to K9 Methylated Histone H3 Is Required to Establish Centromeric Heterochromatin by Schalch, Thomas, Job, Godwin, Noffsinger, Victoria J., Shanker, Sreenath, Kuscu, Canan, Joshua-Tor, Leemor, Partridge, Janet F.

“…In fission yeast, assembly of centromeric heterochromatin requires the RITS complex, which consists of Ago1, Tas3, Chp1, and siRNAs derived from centromeric…”
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Sir2 is required for Clr4 to initiate centromeric heterochromatin assembly in fission yeast by Alper, Benjamin J, Job, Godwin, Yadav, Rajesh K, Shanker, Sreenath, Lowe, Brandon R, Partridge, Janet F

“…Heterochromatin assembly in fission yeast depends on the Clr4 histone methyltransferase, which targets H3K9. We show that the histone deacetylase Sir2 is…”
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Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain by Kouzarides, Tony, Bannister, Andrew J, Zegerman, Philip, Partridge, Janet F, Miska, Eric A, Thomas, Jean O, Allshire, Robin C

“…Heterochromatin protein 1 (HP1) is localized at heterochromatin sites where it mediates gene silencing. The chromo domain of HP1 is necessary for both…”
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The Chp1–Tas3 core is a multifunctional platform critical for gene silencing by RITS by Schalch, Thomas, Job, Godwin, Shanker, Sreenath, Partridge, Janet F, Joshua-Tor, Leemor

“…The RITS complex links the RNAi pathway with centromeric heterochromatin formation in fission yeast and comprises the chromodomain protein Chp1, the GW protein…”
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The Mi-2 Homolog Mit1 Actively Positions Nucleosomes within Heterochromatin To Suppress Transcription by Creamer, Kevin M., Job, Godwin, Shanker, Sreenath, Neale, Geoffrey A., Lin, Yuan-chi, Bartholomew, Blaine, Partridge, Janet F.

“…Mit1 is the putative chromatin remodeling subunit of the fission yeast Snf2/histone deacetylase (HDAC) repressor complex (SHREC) and is known to repress…”
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Histone H3G34R mutation causes replication stress, homologous recombination defects and genomic instability in S. pombe by Yadav, Rajesh K, Jablonowski, Carolyn M, Fernandez, Alfonso G, Lowe, Brandon R, Henry, Ryan A, Finkelstein, David, Barnum, Kevin J, Pidoux, Alison L, Kuo, Yin-Ming, Huang, Jie, O'Connell, Matthew J, Andrews, Andrew J, Onar-Thomas, Arzu, Allshire, Robin C, Partridge, Janet F

“…Recurrent somatic mutations of in aggressive pediatric high-grade gliomas generate K27M or G34R/V mutant histone H3.3. H3.3-G34R/V mutants are common in tumors…”
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Subtelomeric Chromatin in the Fission Yeast S. pombe by Yadav, Rajesh K., Matsuda, Atsushi, Lowe, Brandon R., Hiraoka, Yasushi, Partridge, Janet F.

“…Telomeres play important roles in safeguarding the genome. The specialized repressive chromatin that assembles at telomeres and subtelomeric domains is key to…”
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Requirement of Heterochromatin for Cohesion at Centromeres by Bernard, Pascal, Maure, Jean-François, Partridge, Janet F., Genier, Sylvie, Javerzat, Jean-Paul, Allshire, Robin C.

“…Centromeres are heterochromatic in many organisms, but the mitotic function of this silent chromatin remains unknown. During cell division, newly replicated…”
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Centromeric heterochromatin assembly in fission yeast—balancing transcription, RNA interference and chromatin modification by Alper, Benjamin J, Lowe, Brandon R, Partridge, Janet F

“…Distinct regions of the eukaryotic genome are packaged into different types of chromatin, with euchromatin representing gene rich, transcriptionally active…”
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RITS-connecting transcription, RNA interference, and heterochromatin assembly in fission yeast by Creamer, Kevin M., Partridge, Janet F.

“…In recent years, a bevy of evidence has been unearthed indicating that ‘silent’ heterochromatin is not as transcriptionally inert as once thought. In the…”
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Should I Stay or Should I Go? Chromodomain Proteins Seal the Fate of Heterochromatic Transcripts in Fission Yeast by Creamer, Kevin M., Partridge, Janet F.

“…In this issue of Molecular Cell, Ishida et al. (2012) and Keller et al. (2012) show distinct outcomes for heterochromatic RNAs that bind different chromodomain…”
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DNA Damage Response Checkpoint Activation Drives KP1019 Dependent Pre-Anaphase Cell Cycle Delay in S. cerevisiae by Bierle, Lindsey A, Reich, Kira L, Taylor, Braden E, Blatt, Eliot B, Middleton, Sydney M, Burke, Shawnecca D, Stultz, Laura K, Hanson, Pamela K, Partridge, Janet F, Miller, Mary E

“…Careful regulation of the cell cycle is required for proper replication, cell division, and DNA repair. DNA damage--including that induced by many anticancer…”
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Functional Separation of the Requirements for Establishment and Maintenance of Centromeric Heterochromatin by Partridge, Janet F., DeBeauchamp, Jennifer L., Kosinski, Aaron M., Ulrich, Dagny L., Hadler, Michael J., Noffsinger, Victoria J.P.

“…The establishment and maintenance of centromeric heterochromatin in fission yeast require the RITS complex. Comprised of centromeric siRNAs, the chromodomain…”
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Plasticity of fission yeast CENP-A chromatin driven by relative levels of histone H3 and H4 by Castillo, Araceli G, Mellone, Barbara G, Partridge, Janet F, Richardson, William, Hamilton, Georgina L, Allshire, Robin C, Pidoux, Alison L

“…The histone H3 variant CENP-A assembles into chromatin exclusively at centromeres. The process of CENP-A chromatin assembly is epigenetically regulated…”
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H3K9me-independent gene silencing in fission yeast heterochromatin by Clr5 and histone deacetylases by Hansen, Klavs R, Hazan, Idit, Shanker, Sreenath, Watt, Stephen, Verhein-Hansen, Janne, Bähler, Jürg, Martienssen, Robert A, Partridge, Janet F, Cohen, Amikam, Thon, Geneviève

“…Nucleosomes in heterochromatic regions bear histone modifications that distinguish them from euchromatic nucleosomes. Among those, histone H3 lysine 9…”
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