Search Results - "Parton, G"
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Caveolae: Structure, Function, and Relationship to Disease
Published in Annual review of cell and developmental biology (06-10-2018)“…The plasma membrane of eukaryotic cells is not a simple sheet of lipids and proteins but is differentiated into subdomains with crucial functions. Caveolae,…”
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Caveolae: Formation, dynamics, and function
Published in Current opinion in cell biology (01-08-2020)“…Caveolae are abundant surface pits formed by the assembly of cytoplasmic proteins on a platform generated by caveolin integral membrane proteins and membrane…”
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Biogenesis of the multifunctional lipid droplet: Lipids, proteins, and sites
Published in The Journal of cell biology (03-03-2014)“…Lipid droplets (LDs) are ubiquitous dynamic organelles that store and supply lipids in all eukaryotic and some prokaryotic cells for energy metabolism,…”
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Not just fat: the structure and function of the lipid droplet
Published in Cold Spring Harbor perspectives in biology (01-03-2011)“…Lipid droplets (LDs) are independent organelles that are composed of a lipid ester core and a surface phospholipid monolayer. Recent studies have revealed many…”
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Rab18 promotes lipid droplet (LD) growth by tethering the ER to LDs through SNARE and NRZ interactions
Published in The Journal of cell biology (05-03-2018)“…Lipid incorporation from endoplasmic reticulum (ER) to lipid droplet (LD) is important in controlling LD growth and intracellular lipid homeostasis. However,…”
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Rab18 binds to hepatitis C virus NS5A and promotes interaction between sites of viral replication and lipid droplets
Published in PLoS pathogens (01-08-2013)“…Hepatitis C virus (HCV) is a single-stranded RNA virus that replicates on endoplasmic reticulum-derived membranes. HCV particle assembly is dependent on the…”
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A kinetic view of GPCR allostery and biased agonism
Published in Nature chemical biology (18-08-2017)“…Allosteric modulation and biased agonism at GPCRs could be manifestations of the same underlying 'conformational selection' mechanism, and these can be…”
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Minimum information reporting in bio–nano experimental literature
Published in Nature nanotechnology (01-09-2018)“…Studying the interactions between nanoengineered materials and biological systems plays a vital role in the development of biological applications of…”
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Mammalian lipid droplets are innate immune hubs integrating cell metabolism and host defense
Published in Science (American Association for the Advancement of Science) (16-10-2020)“…Lipid droplets (LDs) are the major lipid storage organelles of eukaryotic cells and a source of nutrients for intracellular pathogens. We demonstrate that…”
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Membrane Curvature and Tension Control the Formation and Collapse of Caveolar Superstructures
Published in Developmental cell (25-02-2019)“…Caveolae, flask-shaped pits covered by caveolin-cavin coats, are abundant features of the plasma membrane of many cells. Besides appearing as single-membrane…”
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Chiral self-assembly of cellulose nanocrystals is driven by crystallite bundles
Published in Nature communications (12-05-2022)“…The transfer of chirality across length-scales is an intriguing and universal natural phenomenon. However, connecting the properties of individual building…”
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ORP2 Delivers Cholesterol to the Plasma Membrane in Exchange for Phosphatidylinositol 4, 5-Bisphosphate (PI(4,5)P2)
Published in Molecular cell (07-02-2019)“…Cholesterol is highly enriched at the plasma membrane (PM), and lipid transfer proteins may deliver cholesterol to the PM in a nonvesicular manner. Here,…”
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Cavin family proteins and the assembly of caveolae
Published in Journal of cell science (01-04-2015)“…Caveolae are an abundant feature of the plasma membrane in many cells. Until recently, they were generally considered to be membrane invaginations whose…”
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14
Development of a human cardiac organoid injury model reveals innate regenerative potential
Published in Development (Cambridge) (15-03-2017)“…The adult human heart possesses a limited regenerative potential following an ischemic event, and undergoes a number of pathological changes in response to…”
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ORP5 and ORP8 bind phosphatidylinositol-4, 5-biphosphate (PtdIns(4,5)P 2 ) and regulate its level at the plasma membrane
Published in Nature communications (02-10-2017)“…ORP5 and ORP8, members of the oxysterol-binding protein (OSBP)-related proteins (ORP) family, are endoplasmic reticulum membrane proteins implicated in lipid…”
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Functional screening in human cardiac organoids reveals a metabolic mechanism for cardiomyocyte cell cycle arrest
Published in Proceedings of the National Academy of Sciences - PNAS (03-10-2017)“…The mammalian heart undergoes maturation during postnatal life to meet the increased functional requirements of an adult. However, the key drivers of this…”
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Adaptor Proteins MiD49 and MiD51 Can Act Independently of Mff and Fis1 in Drp1 Recruitment and Are Specific for Mitochondrial Fission
Published in The Journal of biological chemistry (20-09-2013)“…Drp1 (dynamin-related protein 1) is recruited to both mitochondrial and peroxisomal membranes to execute fission. Fis1 and Mff are Drp1 receptor/effector…”
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SEIPIN Regulates Lipid Droplet Expansion and Adipocyte Development by Modulating the Activity of Glycerol-3-phosphate Acyltransferase
Published in Cell reports (Cambridge) (01-11-2016)“…Berardinelli-Seip congenital lipodystrophy 2 (BSCL2) is caused by loss-of-function mutations in SEIPIN, a protein implicated in both adipogenesis and lipid…”
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Endocytosis Inhibition in Humans to Improve Responses to ADCC-Mediating Antibodies
Published in Cell (05-03-2020)“…A safe and controlled manipulation of endocytosis in vivo may have disruptive therapeutic potential. Here, we demonstrate that the anti-emetic/anti-psychotic…”
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A microtubule-organizing center directing intracellular transport in the early mouse embryo
Published in Science (American Association for the Advancement of Science) (01-09-2017)“…The centrosome is the primary microtubule-organizing center (MTOC) of most animal cells; however, this organelle is absent during early mammalian development…”
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