Search Results - "Parton, A H"

Metabolism of the bisphosphonate ester U-91502 in rats by Slatter, J G, Feenstra, K L, Hauer, M J, Kloosterman, D A, Parton, A H, Sanders, P E, Scott, G, Speed, W

“…The major metabolites of the bisphosphonate ester U-91502 were isolated from the bile and urine of male Sprague-Dawley rats and identified by NMR and MS. Bile…”
Get more information

Purification of the T-Cell Receptor ζ-Chain: Covalent Modification by 4-(2-Aminoethyl)- benzenesulfonyl Fluoride by Sweeney, B., Proudfoot, K., Parton, A.H., King, L.M., Slocombe, P., Perry, M.J.

Get full text

Stereoselective metabolism of two keto-pyrrol analogues of 8-hydroxy-2-dipropyl-aminotetralin by freshly isolated rat hepatocytes by Wood, S.A., Parton, A.H., Simmonds, R.J., Stevenson, D.

“…In vitro metabolism models have been used to determine the relative metabolic stability of novel 2‐aminotetralin analogues for the treatment of CNS diseases…”
Get full text

Squaric acid derivatives as VLA-4 integrin antagonists by PORTER, John R, ARCHIBALD, Sarah C, WARRELLOW, Graham J, ALEXANDER, Rikki P, LANGHAM, Barry, CHILDS, Kirstie, CRITCHLEY, David, HEAD, John C, LINSLEY, Janeen M, PARTON, Ted A. H, ROBINSON, Martyn K, SHOCK, Anthony, TAYLOR, Richard J

“…SAR studies aimed at improving the rate of clearance by the incorporation of a 3,4-diamino-3-cyclobutene-1,2-dione group as an amino acid isostere in a series…”
Get full text

Discovery and evaluation of N-(triazin-1,3,5-yl) phenylalanine derivatives as VLA-4 integrin antagonists by Porter, John R., Archibald, Sarah C., Brown, Julien A., Childs, Kirstie, Critchley, David, Head, John C., Hutchinson, Brian, Parton, Ted A.H., Robinson, Martyn K., Shock, Anthony, Warrellow, Graham J., Zomaya, Alex

“…SAR studies aimed at improving the rate of clearance of a series of VLA-4 integrin antagonists by the introduction of a 1,3,5-triazine as an amide isostere are…”
Get full text

Dehydrophenylalanine derivatives as VLA-4 integrin antagonists by Porter, John R., Archibald, Sarah C., Brown, Julien A., Childs, Kirstie, Critchley, David, Head, John C., Parton, Ted A.H., Robinson, Martyn K., Shock, Anthony, Taylor, Richard J., Warrellow, Graham J.

“…We describe a series of dehydrophenylalanine derivatives where the Z isomers are potent VLA-4 antagonists but are subject to rapid biliary clearance and the E…”
Get full text

N-(Pyrimidin-4-yl) and N-(Pyridin-2-yl) phenylalanine derivatives as VLA-4 integrin antagonists by Porter, John R., Archibald, Sarah C., Brown, Julien A., Childs, Kirstie, Critchley, David, Head, John C., Hutchinson, Brian, Parton, Ted A.H., Robinson, Martyn K., Shock, Anthony, Warrellow, Graham J., Zomaya, Alex

“…The SAR studies to optimise both potency and rate of clearance in the rat for a series of pyrimidine and pyridine based VLA-4 antagonists are described. A…”
Get full text

The use of liquid chromatography/thermospray mass spectrometry with on-line ultraviolet diode array and radiochemical detection: characterization of the putative metabolites of U-78875 in female rat faeces by Speed, W, Parton, A H, Martin, I J, Howard, M R

“…The metabolites of an anxiolytic drug candidate U-78875 [3-(5-cyclopropyl-1,2,4-oxadiazol-3-yl)-5-(1-methylethyl)- imidazo[1,5-alpha]quinoxalin-4(5H)-one; I]…”
Get more information

Identification of an acyclic diterpene alcohol in the defense secretion of soldiers ofReticulitermes lucifugus by Baker, R., Parton, A. H., Howse, P. E.

Get full text

F(ab′) 2 molecules made from Escherichia coli produced Fab′ with hinge sequences conferring increased serum survival in an animal model by Humphreys, David P., Vetterlein, Olivia M., Chapman, Andrew P., King, David J., Antoniw, Pari, Suitters, Amanda J., Reeks, Dominic G., Parton, Ted A.H., King, Lloyd M., Smith, Bryan J., Lang, Volker, Stephens, Paul E.

“…Fab′s with hinges based on the human γ1 sequence containing 1, 2, or 4 cysteines have been produced by high level Escherichia coli periplasmic secretion, and…”
Get full text