Quantitative Analysis of Tomographic Stress Thallium-201 Myocardial Scintigrams: A Multicenter Trial

The accuracy of the previously developed and validated Cedars-Sinai Medical Center (CSMC) computer program for quantitative analysis of thallium-201 (201TI) stress myocardial tomograms was assessed in a multicenter trial consisting of 242 patients with coronary angiography and 76 with a low likeliho...

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Bibliographic Details
Published in:	The Journal of nuclear medicine (1978) Vol. 31; no. 7; pp. 1168 - 1179
Main Authors:	Van Train, Kenneth F, Maddahi, Jamshid, Berman, Daniel S, Kiat, Hosen, Areeda, Joseph, Prigent, Florence, Friedman, John, Participants of Multicenter Trial
Format:	Journal Article
Language:	English
Published:	Reston, VA Soc Nuclear Med 01-07-1990 Society of Nuclear Medicine
Subjects:	ACCURACY ANIMALS BETA DECAY RADIOISOTOPES Biological and medical sciences BODY CARDIOVASCULAR DISEASES CARDIOVASCULAR SYSTEM COMPUTER CODES COMPUTERIZED TOMOGRAPHY Coronary Disease - diagnostic imaging COUNTING TECHNIQUES DAYS LIVING RADIOISOTOPES DIAGNOSIS DIAGNOSTIC TECHNIQUES DISEASES ELECTRON CAPTURE RADIOISOTOPES EMISSION COMPUTED TOMOGRAPHY EXERCISE Exercise Test Female HEART Heart - diagnostic imaging HEAVY NUCLEI Humans Image Interpretation, Computer-Assisted Investigative techniques, diagnostic techniques (general aspects) ISOMERIC TRANSITION ISOTOPES ISOTOPES Male MAMMALS MAN Medical sciences Multicenter Studies as Topic MUSCLES MYOCARDIUM NUCLEI ODD-EVEN NUCLEI ORGANS PATIENTS PRIMATES Prospective Studies RADIOISOTOPE SCANNING RADIOISOTOPES RADIOLOGY AND NUCLEAR MEDICINE Radionuclide investigations Reference Values SCINTISCANNING SECONDS LIVING RADIOISOTOPES SENSITIVITY ANALYSIS Sensitivity and Specificity Sex Factors SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY THALLIUM 201 THALLIUM ISOTOPES Thallium Radioisotopes TOMOGRAPHY Tomography, Emission-Computed, Single-Photon VERTEBRATES 550601 > Medicine > Unsealed Radionuclides in Diagnostics Performance evaluation Radionuclide study Human Multicenter study Cardiovascular disease Coronary heart disease Photon Biomedical data processing Sensitivity Specificity Computerized processing Myocardium Thallium Isotopes Exercise tolerance test Positron emission tomography Quantitative analysis
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Summary:	The accuracy of the previously developed and validated Cedars-Sinai Medical Center (CSMC) computer program for quantitative analysis of thallium-201 (201TI) stress myocardial tomograms was assessed in a multicenter trial consisting of 242 patients with coronary angiography and 76 with a low likelihood (LL) of coronary artery disease (CAD) involving various cameras, computers, and operators. The program utilized gender-matched normal limits developed from 35 LL patients at CSMC. The multicenter results as compared to those of 168 patients from CSMC were not significantly different with respect to the overall sensitivities (94% versus 95%) and specificities (44% versus 56%) for identification of CAD and normalcy rates which were determined in LL patients (82% for both) and with respect to identification of individual diseased arteries. The results indicate that our method for quantifying tomographic 201TI stress scintigrams utilizing standard normal limits can be applied at other institutions by different operators, using a variety of cameras and computers, with similar accuracy to that currently obtained at our institution.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 None
ISSN:	0161-5505 1535-5667