Search Results - "Parsons, Zachary"

Redox regulation of protein tyrosine phosphatases: structural and chemical aspects by Tanner, John J, Parsons, Zachary D, Cummings, Andrea H, Zhou, Haiying, Gates, Kent S

“…Protein tyrosine phosphatases (PTPs) are important targets of the H(2)O(2) that is produced during mammalian signal transduction. H(2)O(2)-mediated…”
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Thiol-Dependent Recovery of Catalytic Activity from Oxidized Protein Tyrosine Phosphatases by Parsons, Zachary D, Gates, Kent S

“…Protein tyrosine phosphatases (PTPs) play an important role in the regulation of mammalian signal transduction. During some cell signaling processes, the…”
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The DNA glycosylase AlkD uses a non-base-flipping mechanism to excise bulky lesions by Mullins, Elwood A., Shi, Rongxin, Parsons, Zachary D., Yuen, Philip K., David, Sheila S., Igarashi, Yasuhiro, Eichman, Brandt F.

“…Crystal structures of the DNA glycosylase AlkD with DNA containing various modified bases show that neither substrate recognition nor catalysis use a…”
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A Catalytic Role for C–H/π Interactions in Base Excision Repair by Bacillus cereus DNA Glycosylase AlkD by Parsons, Zachary D, Bland, Joshua M, Mullins, Elwood A, Eichman, Brandt F

“…DNA glycosylases protect genomic integrity by locating and excising aberrant nucleobases. Substrate recognition and excision usually take place in an…”
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Allylation and Alkylation of Biologically Relevant Nucleophiles by Diallyl Sulfides by Viswanatharaju Ruddraraju, Kasi, Parsons, Zachary D, Lewis, Calvin D, Gates, Kent S

“…Allyl sulfides are bioactive phytochemicals found in garlic, onion, and other members of the genus Allium. Here we showed that diallyl disulfide and diallyl…”
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Body mass and sex, not local climate, drive differences in chill coma recovery times in common garden reared bumble bees by Oyen, K. Jeannet, Jardine, Laura E., Parsons, Zachary M., Herndon, James D., Strange, James P., Lozier, Jeffrey D., Dillon, Michael E.

“…The time required to recover from cold exposure (chill coma recovery time) may represent an important metric of performance and has been linked to geographic…”
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Reactions of 1,3-Diketones with a Dipeptide Isothiazolidin-3-one: Toward Agents That Covalently Capture Oxidized Protein Tyrosine Phosphatase 1B by Ruddraraju, Kasi Viswanatharaju, Parsons, Zachary D, Llufrio, Elizabeth M, Frost, Natasha L, Gates, Kent S

“…Protein tyrosine phosphatase 1B (PTP1B) is a validated therapeutic target for the treatment of type 2 diabetes; however, the enzyme has been classified by some…”
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Divergence in Body Mass, Wing Loading, and Population Structure Reveals Species-Specific and Potentially Adaptive Trait Variation Across Elevations in Montane Bumble Bees by Lozier, Jeffrey D, Parsons, Zachary M, Rachoki, Lois, Jackson, Jason M, Pimsler, Meaghan L, Oyen, Kennan J, Strange, James, Dillon, Michael E

“…Biogeographic clines in morphology along environmental gradients can illuminate forces influencing trait evolution within and between species. Latitude has…”
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Correction to “Allylation and Alkylation of Biologically Relevant Nucleophiles by Diallyl Sulfides” by Ruddraraju, Kasi Viswanatharaju, Parsons, Zachary D, Lewis, Calvin D, Gates, Kent S

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Sulfone-stabilized carbanions for the reversible covalent capture of a posttranslationally-generated cysteine oxoform found in protein tyrosine phosphatase 1B (PTP1B) by Parsons, Zachary D., Ruddraraju, Kasi Viswanatharaju, Santo, Nicholas, Gates, Kent S.

“…[Display omitted] Redox regulation of protein tyrosine phosphatase 1B (PTP1B) involves oxidative conversion of the active site cysteine thiolate into an…”
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The Biological Buffer Bicarbonate/CO2 Potentiates H2O2-Mediated Inactivation of Protein Tyrosine Phosphatases by Zhou, Haiying, Singh, Harkewal, Parsons, Zachary D, Lewis, Sarah M, Bhattacharya, Sanjib, Seiner, Derrick R, LaButti, Jason N, Reilly, Thomas J, Tanner, John J, Gates, Kent S

“…Hydrogen peroxide is a cell signaling agent that inactivates protein tyrosine phosphatases (PTPs) via oxidation of their catalytic cysteine residue. PTPs are…”
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Negative result: 6-(N,N-dimethylamino)fulvene as a reagent for the detection of latent fingermarks on paper surfaces by Wells, Jason M., Parsons, Zachary, Jelly, Renee, Payne, Alan D., Lewis, Simon W.

“…[Display omitted] This is the first report of 6-(N,N-dimethylamino)fulvene (DMAF) as a reagent for the detection of latent fingermarks on porous surfaces…”
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Redox regulation of protein tyrosine phosphatases: methods for kinetic analysis of covalent enzyme inactivation by Parsons, Zachary D, Gates, Kent S

“…Phosphorylation of tyrosine residues is an important posttranslational modification that modulates the function of proteins involved in many important cell…”
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Toward Hypoxia-Selective DNA-Alkylating Agents Built by Grafting Nitrogen Mustards onto the Bioreductively Activated, Hypoxia-Selective DNA-Oxidizing Agent 3‑Amino-1,2,4-benzotriazine 1,4-Dioxide (Tirapazamine) by Johnson, Kevin M, Parsons, Zachary D, Barnes, Charles L, Gates, Kent S

“…Tirapazamine (3-amino-1,2,4-benzotriazine 1,4-dioxide) is a heterocyclic di-N-oxide that undergoes enzymatic deoxygenation selectively in the oxygen-poor…”
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Crystal structure of N -(quinolin-6-yl)hydroxylamine by Rajapakse, Anuruddha, Hillebrand, Roman, Lewis, Sarah M., Parsons, Zachary D., Barnes, Charles L., Gates, Kent S.

“…The title compound, C 9 H 8 N 2 O, crystallized with four independent molecules in the asymmetric unit. The four molecules are linked via one O—H...N and two…”
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Habitat use by desert bighorn sheep during lambing by Bangs, Peter D., Krausman, Paul R., Kunkel, Kyron E., Parsons, Zachary D.

“…Habitat used for predator escape may be a factor limiting restoration of desert bighorn sheep (Ovis canadensis mexicana) in small mountain ranges in New…”
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Computerized tomography platform using beta rays by Paetkau, Owen, Parsons, Zachary, Paetkau, Mark

“…A computerized tomography (CT) system using a 0.1 μCi Sr-90 beta source, Geiger counter, and low density foam samples was developed. A simple algorithm was…”
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Habitat use by female desert bighorn sheep in the Fra Cristobal Mountains, New Mexico, USA by Bangs, Peter D., Krausman, Paul R., Kunkel, Kyran E., Parsons, Zachary D.

“…Mexican desert bighorn sheep (Ovis canadensis mexicana) populations have declined since the 1980s, and restoration efforts are necessary to establish viable…”
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Crystal structure of N-(quinolin-6-yl)hydroxyl-amine by Rajapakse, Anuruddha, Hillebrand, Roman, Lewis, Sarah M, Parsons, Zachary D, Barnes, Charles L, Gates, Kent S

“…The title compound, C9H8N2O, crystallized with four independent mol-ecules in the asymmetric unit. The four mol-ecules are linked via one O-H⋯N and two N-H⋯N…”
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The Biological Buffer Bicarbonate/CO 2 Potentiates H 2 O 2 -Mediated Inactivation of Protein Tyrosine Phosphatases by Zhou, Haiying, Singh, Harkewal, Parsons, Zachary D., Lewis, Sarah M., Bhattacharya, Sanjib, Seiner, Derrick R., LaButti, Jason N., Reilly, Thomas J., Tanner, John J., Gates, Kent S.

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