Search Results - "Parsons, Nicholas J."

Lactate stimulation of gonococcal metabolism in media containing glucose : Mechanism, impact on pathogenicity, and wider implications for other pathogens by SMITH, Harry, YATES, Edwin A, COLE, Jeff A, PARSONS, Nicholas J

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Sialylation of neisserial lipopolysaccharide: a major influence on pathogenicity by Smith, Harry, Parsons, Nicholas J., Cole, Jeffrey A.

“…Examination of bacteria grown in vivo can reveal hitherto unknown determinants of pathogenicity. Gonococci in urethral exudates are resistant to complement…”
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Lactate causes changes in gonococci including increased lipopolysaccharide synthesis during short-term incubation in media containing glucose by Gao, Lihui, Parsons, Nicholas J, Curry, Alan, Cole, Jeff A, Smith, Harry

“…Gonococci (strain BS4(agar)), emerging from lag-phase during 1–1.5 h incubation in a medium containing glucose (28 mM) and either 5 μM or 50 μM sodium lactate,…”
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Corrigendum to “Lactate causes changes in gonococci including increased lipopolysaccharide synthesis during short-term incubation in media containing glucose” by Gao, Lihui, Parsons, Nicholas J., Curry, Alan, Cole, Jeff A., Smith, Harry

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Uptake of metabolites by gonococci grown with lactate in a medium containing glucose: evidence for a surface location of the sialyltransferase by Gao, Lihui, Linden, Luan, Parsons, Nicholas J, Cole, Jeff A, Smith, Harry

“…Promotion of uptake of essential metabolites is a possible reason for the general stimulation of gonococcal metabolism which is caused by lactate (1 mM) in a…”
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Corrigendum to ``Lactate causes changes in gonococci including increased lipopolysaccharide synthesis during short-term incubation in media containing glucose'': [FEMS Microbiol. Lett. 169 (1998) 309–316] by Gao, Lihui, Parsons, Nicholas J, Curry, Alan, Cole, Jeff A, Smith, Harry

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Corrigendum to “Lactate causes changes in gonococci including increased lipopolysaccharide synthesis during short-term incubation in media containing glucoseâ by Gao, Lihui, Parsons, Nicholas J, Curry, Alan, Cole, Jeff A, Smith, Harry

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Corrigendum to “Lactate causes changes in gonococci including increased lipopolysaccharide synthesis during short-term incubation in media containing glucose”: FEMS Microbiol. Lett. 169 (1998) 309–316 by Gao, Lihui, Parsons, Nicholas J, Curry, Alan, Cole, Jeff A, Smith, Harry

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Lactate causes changes in gonococci including increased lipopolysaccharide synthesis during short-term incubation in media containing glucose by Gao, Lihui, Parsons, Nicholas J, Curry, Alan, Cole, Jeff A, Smith, Harry

“…Abstract Gonococci (strain BS4(agar)), emerging from lag-phase during 1–1.5 h incubation in a medium containing glucose (28 mM) and either 5 μM or 50 μM sodium…”
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Functional characterization of a sialyltransferase-deficient mutant of Neisseria gonorrhoeae by Gill, M J, McQuillen, D P, van Putten, J P, Wetzler, L M, Bramley, J, Crooke, H, Parsons, N J, Cole, J A, Smith, H

“…Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon…”
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The sialylation of gonococcal lipopolysaccharide by host factors: a major impact on pathogenicity by Smith, H, Cole, J A, Parsons, N J

“…The resistance of gonococci in most patients to complement mediated killing by human serum is due to sialylation of their lipopolysaccharide (LPS) which…”
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Sialylation of lipopolysaccharide by CMP-NANA in viable gonococci is enhanced by low Mr material released from blood cell extracts but not by some UDP sugars by Parsons, N J, Constantinidou, C, Cole, J A, Smith, H

“…Serum resistance of gonococci in most patients is due to sialylation of a Gal beta 1-4GlcNAc group on a conserved 4.5 kDa lipopolysaccharide (LPS) component by…”
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Sialylation of lipopolysaccharide and loss of absorption of bactericidal antibody during conversion of gonococci to serum resistance by cytidine 5'-monophospho-N-acetyl neuraminic acid by Parsons, N J, Andrade, J R, Patel, P V, Cole, J A, Smith, H

“…Changes in lipopolysaccharide (LPS) which occur when serum susceptible gonococci are converted to resistance by incubation with cytidine…”
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Cytidine 5'-monophospho-N-acetyl neuraminic acid and a low molecular weight factor from human blood cells induce lipopolysaccharide alteration in gonococci when conferring resistance to killing by human serum by Parsons, N J, Patel, P V, Tan, E L, Andrade, J R, Nairn, C A, Goldner, M, Cole, J A, Smith, H

“…Recently evidence has been obtained that a minute amount of cytidine 5'-monophospho-N-acetyl neuraminic acid (CMP-NANA) or a closely related compound is the…”
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Lactate enhancement of sialylation of gonococcal lipopolysaccharide and of induction of serum resistance by CMP-NANA is not due to direct activation of the sialyltransferase: metabolic events are involved by Parsons, Nicholas J., Emond, Jean-Philippe, Goldner, Morris, Bramley, Jennifer, Crooke, Helen, Cole, Jeff A., Smith, Harry

“…Lactate enhances lipopolysaccharide (LPS) sialylation and induction of serum resistance in gonococci by CMP-NANA. To investigate whether the enhancement is due…”
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Lactic acid is the factor in blood cell extracts which enhances the ability of CMP-NANA to sialylate gonococcal lipopolysaccharide and induce serum resistance by Parsons, Nicholas J., Boons, Geert-Jans, Ashton, Peter R., Redfern, Peter D., Quirk, Philip, Gao, Yuan, Constantinidou, Chrystala, Patel, Jetesh, Bramley, Jennifer, Cole, Jeffrey A., Smith, Harry

“…In previous work, a factor which enhances the ability of cytidine 5′-monophospho-N-acetyl neuraminic acid (CMP-NANA) to sialylate gonococcal lipopolysaccharide…”
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The serum resistance of gonococci in the majority of urethral exudates is due to sialylated lipopolysaccharide seen as a surface coat by Parsons, N J, Curry, A, Fox, A J, Jones, D M, Cole, J A, Smith, H

“…Examined before subculture, gonococci in 18 urethral exudates collected from different patients were serum-resistant. For 15 exudates, the resistance was…”
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A high Mr factor in human blood which confers serum resistance on gonococci: some properties and synergism with CMP-NANA by Constantinidou, C, Beadle, D, Zhou, X H, Parsons, N J, Sammons, C C, Cole, J A, Smith, H

“…A high relative molecular mass (M(r)) component which confers serum resistance on gonococci has been purified about 300-fold from a dialysed sonicate of human…”
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The surface structure seen on gonococci after treatment with CMP-NANA is due to sialylation of surface lipopolysaccharide previously described as a 'capsule' by Fox, A J, Curry, A, Jones, D M, Demarco de Hormaeche, R, Parsons, N J, Cole, J A, Smith, H

“…Phenotypic serum resistance of gonococci in urethral exudates is due to sialylation of lipopolysaccharide (LPS) by host cytidine 5'-monophospho-N-acetyl…”
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Serum killing of meningococci and several other gram-negative bacterial species is not decreased by incubating them with cytidine 5'-monophospho-N-acetyl neuraminic acid by Fox, A J, Jones, D M, Scotland, S M, Rowe, B, Smith, A, Brown, M R, Fitzgeorge, R G, Baskerville, A, Parsons, N J, Cole, J A

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