Search Results - "Parsons, Melissa J"

BOK Is a Non-canonical BCL-2 Family Effector of Apoptosis Regulated by ER-Associated Degradation by Llambi, Fabien, Wang, Yue-Ming, Victor, Bernadette, Yang, Mao, Schneider, Desiree M., Gingras, Sébastien, Parsons, Melissa J., Zheng, Janet H., Brown, Scott A., Pelletier, Stéphane, Moldoveanu, Tudor, Chen, Taosheng, Green, Douglas R.

“…The mitochondrial pathway of apoptosis is initiated by mitochondrial outer membrane permeabilization (MOMP). The BCL-2 family effectors BAX and BAK are thought…”
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Limited Mitochondrial Permeabilization Causes DNA Damage and Genomic Instability in the Absence of Cell Death by Ichim, Gabriel, Lopez, Jonathan, Ahmed, Shafiq U., Muthalagu, Nathiya, Giampazolias, Evangelos, Delgado, M. Eugenia, Haller, Martina, Riley, Joel S., Mason, Susan M., Athineos, Dimitris, Parsons, Melissa J., van de Kooij, Bert, Bouchier-Hayes, Lisa, Chalmers, Anthony J., Rooswinkel, Rogier W., Oberst, Andrew, Blyth, Karen, Rehm, Markus, Murphy, Daniel J., Tait, Stephen W.G.

“…During apoptosis, the mitochondrial outer membrane is permeabilized, leading to the release of cytochrome c that activates downstream caspases. Mitochondrial…”
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NPM1 directs PIDDosome-dependent caspase-2 activation in the nucleolus by Ando, Kiyohiro, Parsons, Melissa J, Shah, Richa B, Charendoff, Chloé I, Paris, Sheré L, Liu, Peter H, Fassio, Sara R, Rohrman, Brittany A, Thompson, Ruth, Oberst, Andrew, Sidi, Samuel, Bouchier-Hayes, Lisa

“…The PIDDosome (PIDD-RAIDD-caspase-2 complex) is considered to be the primary signaling platform for caspase-2 activation in response to genotoxic stress. Yet…”
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Mitochondria in cell death by Parsons, Melissa J, Green, Douglas R

“…Apoptosis can be thought of as a signalling cascade that results in the death of the cell. Properly executed apoptosis is critically important for both…”
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The BCL-2 Family Reunion by Chipuk, Jerry E., Moldoveanu, Tudor, Llambi, Fabien, Parsons, Melissa J., Green, Douglas R.

“…B cell CLL/lymphoma-2 (BCL-2) and its relatives comprise the BCL-2 family of proteins, which were originally characterized with respect to their roles in…”
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Caspase-2 regulates S-phase cell cycle events to protect from DNA damage accumulation independent of apoptosis by Boice, Ashley G., Lopez, Karla E., Pandita, Raj K., Parsons, Melissa J., Charendoff, Chloe I., Charaka, Vijay, Carisey, Alexandre F., Pandita, Tej K., Bouchier-Hayes, Lisa

“…In addition to its classical role in apoptosis, accumulating evidence suggests that caspase-2 has non-apoptotic functions, including regulation of cell…”
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Correction: Caspase-2 regulates S-phase cell cycle events to protect from DNA damage accumulation independent of apoptosis by Boice, Ashley G., Lopez, Karla E., Pandita, Raj K., Parsons, Melissa J., Charendoff, Chloe I., Charaka, Vijay, Carisey, Alexandre F., Pandita, Tej K., Bouchier-Hayes, Lisa

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Detection of Initiator Caspase Induced Proximity in Single Cells by Caspase Bimolecular Fluorescence Complementation by Parsons, Melissa J, Fassio, Sara R, Bouchier-Hayes, Lisa

“…The caspase family of proteases includes key regulators of apoptosis and inflammation. The caspases can be divided into two groups, the initiator caspases and…”
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Measuring initiator caspase activation by bimolecular fluorescence complementation by Parsons, Melissa J, Bouchier-Hayes, Lisa

“…Initiator caspases, including caspase-2, -8, and -9, are activated by the proximity-driven dimerization that occurs after their recruitment to activation…”
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Resistance to Caspase-Independent Cell Death Requires Persistence of Intact Mitochondria by Tait, Stephen W.G., Parsons, Melissa J., Llambi, Fabien, Bouchier-Hayes, Lisa, Connell, Samuel, Muñoz-Pinedo, Cristina, Green, Douglas R.

“…During apoptosis, mitochondrial outer membrane permeabilization (MOMP) is often a point-of-no-return; death can proceed even if caspase activation is…”
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Measuring caspase activity by Förster resonance energy transfer by Rehm, Markus, Parsons, Melissa J, Bouchier-Hayes, Lisa

“…Förster resonance energy transfer (FRET) occurs across very short distances (in the nanometer range) between donor and acceptor fluorophores that overlap in…”
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Imaging-based methods for assessing caspase activity in single cells by Parsons, Melissa J, Rehm, Markus, Bouchier-Hayes, Lisa

“…Caspases, a family of proteases that are essential mediators of apoptosis, are divided into two groups: initiator caspases and executioner caspases. Each…”
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Death receptors and mitochondria: Life depends on the liver by Parsons, Melissa J., Green, Douglas R.

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Silencing of TMS1/ASC Promotes Resistance to Anoikis in Breast Epithelial Cells by PARSONS, Melissa J, PATEL, Pritty, BRAT, Daniel J, COLBERT, Laronna, VERTINO, Paula M

“…Ductal carcinoma in situ (DCIS) is characterized by ductal epithelial cells that have filled the luminal space of the breast duct and survive despite loss of…”
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Limited Mitochondrial Permeabilization Causes DNA Damage and Genomic Instability in the Absence of Cell Death by Ichim, Gabriel, Lopez, Jonathan, Ahmed, Shafiq U., Muthalagu, Nathiya, Giampazolias, Evangelos, Delgado, M. Eugenia, Haller, Martina, Riley, Joel S., Mason, Susan M., Athineos, Dimitris, Parsons, Melissa J., van de Kooij, Bert, Bouchier-Hayes, Lisa, Chalmers, Anthony J., Rooswinkel, Rogier W., Oberst, Andrew, Blyth, Karen, Rehm, Markus, Murphy, Daniel J., Tait, Stephen W.G.

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Functional characterization of TMS1 /ASC in apoptotic signaling by Parsons, Melissa J

“…Aberrant DNA methylation of promoter region CpG islands is associated with gene silencing and serves as an alternative to mutations in the inactivation of…”
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Functional characterization of TMS1/ASC in apoptotic signaling by Parsons, Melissa J

“…Aberrant DNA methylation of promoter region CpG islands is associated with gene silencing and serves as an alternative to mutations in the inactivation of…”
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Mitochondria and apoptosis: a quick take on a long view by Parsons, Melissa J, Green, Douglas R

“…Fifteen years of apoptosis research have led to the widely accepted idea that the major form of programmed cell death in mammals proceeds via the mitochondria,…”
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