Search Results - "Parsons, Kathryn"

Trastuzumab-DM1 (T-DM1) retains all the mechanisms of action of trastuzumab and efficiently inhibits growth of lapatinib insensitive breast cancer by Junttila, Teemu T., Li, Guangmin, Parsons, Kathryn, Phillips, Gail Lewis, Sliwkowski, Mark X.

“…Trastuzumab (Herceptin ® ) is currently used as a treatment for patients whose breast tumors overexpress HER2/ErbB2. Trastuzumab-DM1 (T-DM1, trastuzumab…”
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Targeting HER2-positive breast cancer with trastuzumab-DM1, an antibody-cytotoxic drug conjugate by Lewis Phillips, Gail D, Li, Guangmin, Dugger, Debra L, Crocker, Lisa M, Parsons, Kathryn L, Mai, Elaine, Blättler, Walter A, Lambert, John M, Chari, Ravi V J, Lutz, Robert J, Wong, Wai Lee T, Jacobson, Frederic S, Koeppen, Hartmut, Schwall, Ralph H, Kenkare-Mitra, Sara R, Spencer, Susan D, Sliwkowski, Mark X

“…HER2 is a validated target in breast cancer therapy. Two drugs are currently approved for HER2-positive breast cancer: trastuzumab (Herceptin), introduced in…”
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Conjugation site modulates the in vivo stability and therapeutic activity of antibody-drug conjugates by Shen, Ben-Quan, Xu, Keyang, Liu, Luna, Raab, Helga, Bhakta, Sunil, Kenrick, Margaret, Parsons-Reponte, Kathryn L, Tien, Janet, Yu, Shang-Fan, Mai, Elaine, Li, Dongwei, Tibbitts, Jay, Baudys, Jakub, Saad, Ola M, Scales, Suzie J, McDonald, Paul J, Hass, Philip E, Eigenbrot, Charles, Nguyen, Trung, Solis, Willy A, Fuji, Reina N, Flagella, Kelly M, Patel, Darshana, Spencer, Susan D, Khawli, Leslie A, Ebens, Allen, Wong, Wai Lee, Vandlen, Richard, Kaur, Surinder, Sliwkowski, Mark X, Scheller, Richard H, Polakis, Paul, Junutula, Jagath R

“…Conjugating drugs to therapeutic antibodies is a promising strategy to increase their therapeutic efficacy. Shen et al. show that the local chemical…”
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Ligand-Independent HER2/HER3/PI3K Complex Is Disrupted by Trastuzumab and Is Effectively Inhibited by the PI3K Inhibitor GDC-0941 by Junttila, Teemu T., Akita, Robert W., Parsons, Kathryn, Fields, Carter, Lewis Phillips, Gail D., Friedman, Lori S., Sampath, Deepak, Sliwkowski, Mark X.

“…Herceptin (trastuzumab) is the backbone of HER2-directed breast cancer therapy and benefits patients in both the adjuvant and metastatic settings. Here, we…”
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Engineered Thio-Trastuzumab-DM1 Conjugate with an Improved Therapeutic Index to Target Human Epidermal Growth Factor Receptor 2-Positive Breast Cancer by JUNUTULA, Jagath R, FLAGELLA, Kelly M, MAI, Elaine, LEWIS PHILLIPS, Gail D, HIRARAGI, Hajime, FUJI, Reina N, TIBBITTS, Jay, VANDLEN, Richard, SPENCER, Susan D, SCHELLER, Richard H, POLAKIS, Paul, SLIWKOWSKI, Mark X, GRAHAM, Richard A, PARSONS, Kathryn L, HA, Edward, RAAB, Helga, BHAKTA, Sunil, NGUYEN, Trung, DUGGER, Debra L, GUANGMIN LI

“…Antibody drug conjugates (ADCs) combine the ideal properties of both antibodies and cytotoxic drugs by targeting potent drugs to the antigen-expressing tumor…”
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Using Semantic Context to Rank the Results of Keyword Search by Butavicius, Marcus A., Parsons, Kathryn M., McCormac, Agata, Dennis, Simon J., Ceglar, Aaron, Weber, Derek, Ferguson, Lael, Treharne, Kenneth, Leibbrandt, Richard, Powers, David

“…In an empirical user study, we assessed two approaches to ranking the results from a keyword search using semantic contextual match based on Latent Semantic…”
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Can Cyberloafing and Internet Addiction Affect Organizational Information Security? by Hadlington, Lee, Parsons, Kathryn

“…Researchers have noted potential links between Internet addiction, the use of work computers for nonwork purposes and an increased risk of threat to the…”
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An assessment of email and spontaneous dialog visualizations by Butavicius, Marcus A., Lee, Michael D., Pincombe, Brandon M., Mullen, Louise G., Navarro, Daniel J., Parsons, Kathryn M., McCormac, Agata

“…Two experiments were conducted examining the effectiveness of visualizations of unstructured texts. The first experiment presented transcriptions of…”
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Message matters: Correcting organisational fake news by Kropf, Benjamin, Wood, Martin, Parsons, Kathryn

“…Misinformation and fake news represent significant strategic and financial risks to organisations. To dispute or manage fake news, organisations are often…”
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Determining employee awareness using the Human Aspects of Information Security Questionnaire (HAIS-Q) by Parsons, Kathryn, McCormac, Agata, Butavicius, Marcus, Pattinson, Malcolm, Jerram, Cate

“…It is increasingly acknowledged that many threats to an organisation's computer systems can be attributed to the behaviour of computer users. To quantify these…”
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Site-Specific Trastuzumab Maytansinoid Antibody–Drug Conjugates with Improved Therapeutic Activity through Linker and Antibody Engineering by Pillow, Thomas H, Tien, Janet, Parsons-Reponte, Kathryn L, Bhakta, Sunil, Li, Hao, Staben, Leanna R, Li, Guangmin, Chuh, Josefa, Fourie-O’Donohue, Aimee, Darwish, Martine, Yip, Victor, Liu, Luna, Leipold, Douglas D, Su, Dian, Wu, Elmer, Spencer, Susan D, Shen, Ben-Quan, Xu, Keyang, Kozak, Katherine R, Raab, Helga, Vandlen, Richard, Lewis Phillips, Gail D, Scheller, Richard H, Polakis, Paul, Sliwkowski, Mark X, Flygare, John A, Junutula, Jagath R

“…Antibody–drug conjugates (ADCs) have a significant impact toward the treatment of cancer, as evidenced by the clinical activity of the recently approved ADCs,…”
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Predicting susceptibility to social influence in phishing emails by Parsons, Kathryn, Butavicius, Marcus, Delfabbro, Paul, Lillie, Meredith

“…•A total of 985 participants completed a role play scenario-based phishing study.•The presence of social influence principles influenced phishing…”
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Individual differences and Information Security Awareness by McCormac, Agata, Zwaans, Tara, Parsons, Kathryn, Calic, Dragana, Butavicius, Marcus, Pattinson, Malcolm

“…The main purpose of this study was to examine the relationship between individuals' Information Security Awareness (ISA) and individual difference variables,…”
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The Human Aspects of Information Security Questionnaire (HAIS-Q): Two further validation studies by Parsons, Kathryn, Calic, Dragana, Pattinson, Malcolm, Butavicius, Marcus, McCormac, Agata, Zwaans, Tara

“…Information security awareness (ISA) is integral to protecting an organisation from cyber threats. The aim of this paper is to further establish the validity…”
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The design of phishing studies: Challenges for researchers by Parsons, Kathryn, McCormac, Agata, Pattinson, Malcolm, Butavicius, Marcus, Jerram, Cate

“…In this paper, a role play scenario experiment of people's ability to differentiate between phishing and genuine emails demonstrated limitations in the…”
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When believing in technology leads to poor cyber security: Development of a trust in technical controls scale by Butavicius, Marcus, Parsons, Kathryn, Lillie, Meredith, McCormac, Agata, Pattinson, Malcolm, Calic, Dragana

“…While technical controls can reduce vulnerabilities to cyber threats, no technology provides absolute protection and we hypothesised that people may act less…”
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Matching training to individual learning styles improves information security awareness by Pattinson, Malcolm, Butavicius, Marcus, Lillie, Meredith, Ciccarello, Beau, Parsons, Kathryn, Calic, Dragana, McCormac, Agata

“…Purpose This paper aims to introduce the concept of a framework of cyber-security controls that are adaptable to different types of organisations and different…”
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The effect of resilience and job stress on information security awareness by McCormac, Agata, Calic, Dragana, Parsons, Kathryn, Butavicius, Marcus, Pattinson, Malcolm, Lillie, Meredith

“…Purpose The purpose of this study was to investigate the relationship between resilience, job stress and information security awareness (ISA). The study…”
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Superior In vivo Efficacy of Afucosylated Trastuzumab in the Treatment of HER2-Amplified Breast Cancer by JUNTTILA, Teemu T, PARSONS, Kathryn, TOTPAL, Klara, KELLEY, Robert F, SLIWKOWSKI, Mark X, OLSSON, Christine, YANMEI LU, YAN XIN, THERIAULT, Julie, CROCKER, Lisa, PABONAN, Oliver, BAGINSKI, Tomasz, MENG, Gloria

“…The enhancement of immune effector functions has been proposed as a potential strategy for increasing the efficacy of therapeutic antibodies. Here, we show…”
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Managing information security awareness at an Australian bank: a comparative study by Pattinson, Malcolm, Butavicius, Marcus, Parsons, Kathryn, McCormac, Agata, Calic, Dragana

“…Purpose The aim of this study was first to confirm that a specific bank’s employees were generally more information security-aware than employees in other…”
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