Search Results - "Parsons, Christopher G."

Positive and Negative Modulation of Group I Metabotropic Glutamate Receptors by Vanejevs, Maksims, Jatzke, Claudia, Renner, Steffen, Müller, Sibylle, Hechenberger, Mirko, Bauer, Tanja, Klochkova, Anna, Pyatkin, Ilya, Kazyulkin, Denis, Aksenova, Elena, Shulepin, Sergey, Timonina, Olga, Haasis, Ariane, Gutcaits, Aleksandrs, Parsons, Christopher G, Kauss, Valerjans, Weil, Tanja

“…A discriminating pharmacophore model for noncompetitive metabotropic glutamate receptor antagonists of subtype 1 (mGluR1) was developed that facilitated the…”
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Predicting Compound Selectivity by Self-Organizing Maps: Cross-Activities of Metabotropic Glutamate Receptor Antagonists by Noeske, Tobias, Sasse, Britta C., Stark, Holger, Parsons, Christopher G., Weil, Tanja, Schneider, Gisbert

“…A topological pharmacophore descriptor (CATS) and a self‐organizing map (SOM) were used for prediction of multiple receptor interaction of known mGluR…”
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Virtual Screening for Selective Allosteric mGluR1 Antagonists and Structure-Activity Relationship Investigations for Coumarine Derivatives by Noeske, Tobias, Jirgensons, Aigars, Starchenkovs, Igors, Renner, Steffen, Jaunzeme, Ieva, Trifanova, Dina, Hechenberger, Mirko, Bauer, Tanja, Kauss, Valerjans, Parsons, Christopher G., Schneider, Gisbert, Weil, Tanja

“…A virtual screening study towards novel noncompetitive antagonists of the metabotropic glutamate receptor 1 (mGluR1) is described. Alignment‐free topological…”
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Searching for Drug Scaffolds with 3D Pharmacophores and Neural Network Ensembles by Renner, Steffen, Hechenberger, Mirko, Noeske, Tobias, Böcker, Alexander, Jatzke, Claudia, Schmuker, Michael, Parsons, Christopher G, Weil, Tanja, Schneider, Gisbert

“…No longer lost in space: A virtual screening approach for the mapping of chemical space using supervised and unsupervised neural networks is presented. Novel…”
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The anaesthetic xenon partially restores an amyloid beta-induced impairment in murine hippocampal synaptic plasticity by Bürge, Martina, Kratzer, Stephan, Mattusch, Corinna, Hofmann, Carolin, Kreuzer, Matthias, Parsons, Christopher G., Rammes, Gerhard

“…It is controversially discussed whether general anaesthesia increases the risk of Alzheimer's disease (AD) or accelerates its progression. One important factor…”
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MRZ-99030 – A novel modulator of Aβ aggregation: I – Mechanism of action (MoA) underlying the potential neuroprotective treatment of Alzheimer's disease, glaucoma and age-related macular degeneration (AMD) by Parsons, Christopher G., Ruitenberg, Maarten, Freitag, Christine E., Sroka-Saidi, Kamila, Russ, Hermann, Rammes, Gerhard

“…Therapeutic approaches addressing β-amyloid1–42 (Aβ1–42) aggregation represent a promising neuroprotective strategy for the treatment of Alzheimer's disease,…”
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New Allosteric Modulators of Metabotropic Glutamate Receptor 5 (mGluR5) Found by Ligand-Based Virtual Screening by Renner, Steffen, Noeske, Tobias, Parsons, Christopher G, Schneider, Petra, Weil, Tanja, Schneider, Gisbert

“…Ligand‐based pharmacophore searching identified new allosteric modulators of metabotropic glutamate receptor 5 (mGluR5), a class III G protein‐coupled…”
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Inhalational Anesthetics Do Not Deteriorate Amyloid-β-Derived Pathophysiology in Alzheimer's Disease: Investigations on the Molecular, Neuronal, and Behavioral Level by Hofmann, Carolin, Sander, Annika, Wang, Xing Xing, Buerge, Martina, Jungwirth, Bettina, Borgstedt, Laura, Kreuzer, Matthias, Kopp, Claudia, Schorpp, Kenji, Hadian, Kamyar, Wotjak, Carsten T, Ebert, Tim, Ruitenberg, Maarten, Parsons, Christopher G, Rammes, Gerhard

“…Studies suggest that general anesthetics like isoflurane and sevoflurane may aggravate Alzheimer's disease (AD) neuropathogenesis, e.g., increased amyloid-β…”
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MRZ-99030 – A novel modulator of Aβ aggregation: II – Reversal of Aβ oligomer-induced deficits in long-term potentiation (LTP) and cognitive performance in rats and mice by Rammes, Gerhard, Gravius, Andreas, Ruitenberg, Maarten, Wegener, Nico, Chambon, Caroline, Sroka-Saidi, Kamila, Jeggo, Ross, Staniaszek, Lydia, Spanswick, Dave, O'Hare, Eugene, Palmer, Philip, Kim, Eun-Mee, Bywalez, Wolfgang, Egger, Veronica, Parsons, Christopher G.

“…β-amyloid1-42 (Aβ1-42) is a major endogenous pathogen underlying the aetiology of Alzheimer's disease (AD). Recent evidence indicates that soluble Aβ…”
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REVERSAL OF AB-INDUCED DEFICITS IN LONG-TERM POTENTIATION (LTP) IN VITRO AND IN VIVO BY MRZ-99030 by Parsons, Christopher G, Jeggo, Ross David, Staniaszek, Lydia, Spanswick, David, Rammes, Gerhard

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Synergism of virtual screening and medicinal chemistry: Identification and optimization of allosteric antagonists of metabotropic glutamate receptor 1 by Noeske, Tobias, Trifanova, Dina, Kauss, Valerjans, Renner, Steffen, Parsons, Christopher G., Schneider, Gisbert, Weil, Tanja

“…We report the identification of novel potent and selective metabotropic glutamate receptor 1 (mGluR1) antagonists by virtual screening and subsequent hit…”
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Pharmacological characterization of MRZ-8676, a novel negative allosteric modulator of subtype 5 metabotropic glutamate receptors (mGluR5): focus on l-DOPA-induced dyskinesia by Dekundy, Andrzej, Gravius, Andreas, Hechenberger, Mirko, Pietraszek, Małgorzata, Nagel, Jens, Tober, Carsten, van der Elst, Martine, Mela, Flora, Parsons, Christopher G., Danysz, Wojciech

“…Subtype 5 metabotropic glutamate receptors (mGluR5) are abundant in the basal ganglia, amygdala, septum, hippocampus, peripheral sensory neurones and dorsal…”
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Effects of sarizotan in animal models of ADHD: challenging pharmacokinetic–pharmacodynamic relationships by Danysz, Wojciech, Flik, Gunnar, McCreary, Andrew, Tober, Carsten, Dimpfel, Wilfried, Bizot, Jean C., Kostrzewa, Richard, Brown, Russell W., Jatzke, Claudia C., Greco, Sergio, Jenssen, Ann-Kristin, Parsons, Christopher G.

“…Sarizotan 1-[(2R)-3,4-dihydro-2H-chromen-2-yl]-N-[[5-(4-fluorophenyl) pyridin-3-yl]methyl] methenamine, showed an in vivo pharmaco-EEG profile resembling that…”
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Memantine reverses ß-amyloid oligomers-induced deficits in long term potentiation (LTP) in murine hippocampal slices by Parsons, Christopher G, Albrecht, Miriam, Rammes, Gerhard

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Inhibition of the α9α10 nicotinic cholinergic receptor by neramexane, an open channel blocker of N-methyl- d-aspartate receptors by Plazas, Paola V., Savino, Jessica, Kracun, Sebastian, Gomez-Casati, María E., Katz, Eleonora, Parsons, Christopher G., Millar, Neil S., Elgoyhen, Ana B.

“…In this study we report the effects of neramexane, a novel amino-alkyl-cyclohexane derivative that is a non-competitive N-methyl- d-aspartate (NMDA) receptor…”
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GluN2A and GluN2B NMDA Receptor Subunits Differentially Modulate Striatal Output Pathways and Contribute to Levodopa-Induced Abnormal Involuntary Movements in Dyskinetic Rats by Mabrouk, Omar S, Mela, Flora, Calcagno, Mariangela, Budri, Mirco, Viaro, Riccardo, Dekundy, Andrzej, Parsons, Christopher G, Auberson, Yves P, Morari, Michele

“…Dual probe microdialysis was used to investigate whether GluN2A and GluN2B NMDA receptor subunits regulate striatal output pathways under dyskinetic…”
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3-Nitropropionic acid toxicity in hippocampus: Protection through N-methyl-D-aspartate receptor antagonism by Karanian, David A., Baude, Andrea S., Brown, Queenie B., Parsons, Christopher G., Bahr, Ben A.

“…The over‐activation of glutamate receptors can lead to excitotoxic cell death and is believed to be involved in the progression of neurodegenerative events in…”
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Are neuronal nicotinic receptors a target for antiepileptic drug development? Studies in different seizure models in mice and rats by Löscher, Wolfgang, Potschka, Heidrun, Wlaź, Piotr, Danysz, Wojciech, Parsons, Christopher G

“…Altered function of neuronal nicotinic acetylcholine receptors in the brain has recently been associated with an idiopathic form of partial epilepsy,…”
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3-Nitropropionic acid toxicity in hippocampus: Protection throughN-methyl-D-aspartate receptor antagonism by Karanian, David A., Baude, Andrea S., Brown, Queenie B., Parsons, Christopher G., Bahr, Ben A.

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Pharmacodynamics of Memantine: An Update by Rammes, G, Danysz, W, Parsons, C G

“…Memantine received marketing authorization from the European Agency for the Evaluation of Medicinal Products (EMEA) for the treatment of moderately severe to…”
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