Search Results - "Parsey, R V"

Characterization of brain mGluR5 binding in a pilot study of late-life major depressive disorder using positron emission tomography and [11C]ABP688 by DeLorenzo, C, Sovago, J, Gardus, J, Xu, J, Yang, J, Behrje, R, Kumar, J S D, Devanand, D P, Pelton, G H, Mathis, C A, Mason, N S, Gomez-Mancilla, B, Aizenstein, H, Mann, J J, Parsey, R V

“…The metabotropic glutamate receptor subtype 5 (mGluR5) has been implicated in the pathophysiology of mood and anxiety disorders and is a potential treatment…”
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Ketamine-induced reduction in mGluR5 availability is associated with an antidepressant response: an [11C]ABP688 and PET imaging study in depression by Esterlis, I, DellaGioia, N, Pietrzak, R H, Matuskey, D, Nabulsi, N, Abdallah, C G, Yang, J, Pittenger, C, Sanacora, G, Krystal, J H, Parsey, R V, Carson, R E, DeLorenzo, C

“…The mechanisms of action of the rapid antidepressant effects of ketamine, an N -methyl- D -aspartate glutamate receptor antagonist, have not been fully…”
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In Vivo Quantification of Brain Serotonin Transporters in Humans Using [11C]McN 5652 by Parsey, Ramin V, Kegeles, Lawrence S, Hwang, Dah-Ren, Simpson, Norman, Abi-Dargham, Anissa, Mawlawi, Osama, Slifstein, Mark, Van Heertum, Ronald L, Mann, J. John, Laruelle, Marc

“…Abnormal brain regional densities of serotonin (5-hydroxytryptamine [5-HT]) transporters have been reported in postmortem studies in several neuropsychiatric…”
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Biodistribution, Toxicology, and Radiation Dosimetry of 5-HT1A-Receptor Agonist Positron Emission Tomography Ligand [11C]CUMI-101 by Kumar, Dileep J. S., Bai, Bing, Ng, Hanna H., Mirsalis, Jon C., Erlandsson, Kjell, Milak, Matthew S., Majo, Vattoly J., Prabhakaran, Jaya, Mann, J. J., Parsey, R. V.

“…Sprague Dawley rats (10/sex/group) were given a single intravenous (iv) dose of CUMI-101 to determine acute toxicity of CUMI-101 and radiation dosimetry…”
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Altered Serotonin 1A Binding in Major Depression: A [carbonyl-C-11]WAY100635 Positron Emission Tomography Study by Parsey, Ramin V., Oquendo, Maria A., Ogden, R. Todd, Olvet, Doreen M., Simpson, Norman, Huang, Yung-yu, Van Heertum, Ronald L., Arango, Victoria, Mann, J. John

“…Serotonin 1A receptors (5-HT 1A) are implicated in the pathophysiology of major depressive disorder (MDD) and in the action of selective serotonin reuptake…”
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Effects of sex, age, and aggressive traits in man on brain serotonin 5-HT1A receptor binding potential measured by PET using [C-11]WAY-100635 by PARSEY, Ramin V, OQUENDO, Maria A, SIMPSON, Norman R, OGDEN, R. Todd, VAN HEERTUM, Ronald, ARANGO, Victoria, MANN, J. John

“…Serotonin (5-HT) 1A receptors have been implicated in a variety of conditions including, depression, suicidal behavior, and aggression. Post-mortem brain…”
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Validation and Reproducibility of Measurement of 5-HT1A Receptor Parameters with [carbonyl-11C]WAY-100635 in Humans: Comparison of Arterial and Reference Tissue Input Functions by Parsey, Ramin V., Slifstein, Mark, Hwang, Dah-Ren, Abi-Dargham, Anissa, Simpson, Norman, Mawlawi, Osama, Guo, Ning-Ning, Van Heertum, Ronald, Mann, J. John, Laruelle, Marc

“…Serotonin 5-HT1A receptors are implicated in the pathophysiology of neuropsychiatric conditions. The goal of this study was to evaluate methods to derive…”
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Quantitative analysis of T2 signal intensities in Alzheimer's Disease by Parsey, Ramin Vaziri, Krishnan, K.Rama Ranga

“…Hypointensities (focal areas of decreased signal intensity) have been reported on T2 weighted magnetic resonance images (MRI) in normal aging and in some…”
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Differential occupancy of somatodendritic and postsynaptic 5HT(1A) receptors by pindolol: a dose-occupancy study with [11C]WAY 100635 and positron emission tomography in humans by Martinez, D, Hwang, D, Mawlawi, O, Slifstein, M, Kent, J, Simpson, N, Parsey, R V, Hashimoto, T, Huang, Y, Shinn, A, Van Heertum, R, Abi-Dargham, A, Caltabiano, S, Malizia, A, Cowley, H, Mann, J J, Laruelle, M

“…Augmentation of selective serotonin reuptake inhibitors (SSRIs) therapy by the 5-HT(1A) receptor agent pindolol may reduce the delay between initiation of…”
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Ascorbic acid modulation of calcium channels in pancreatic β cells by PARSEY, R. V, MATTESON, D. R

“…We have studied the effect of ascorbic acid on voltage-dependent calcium channels in pancreatic beta cells. Using the whole-cell and perforated-patch variants…”
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Derivation of [ 11C]WAY-100635 binding parameters with reference tissue models: effect of violations of model assumptions by Slifstein, Mark, Parsey, Ramin V, Laruelle, Marc

“…In several positron-emission tomography studies of human subjects, analyses of data from the 5-hydroxytryptamine 1A (5-HT 1A) receptor radioligand, […”
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Analysis and use of the perforated patch technique for recording ionic currents in pancreatic β-cells by SALA, S, PARSEY, R. V, COHEN, A. S, MATTESON, D. R

“…We have used the nystatin perforated patch technique to study ionic currents in rat pancreatic beta-cells. The access resistance (Ra) between the pipette and…”
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Ketamine-induced reduction in mGluR5 availability is associated with an antidepressant response: an 11CABP688 and PET imaging study in depression by Esterlis, I, DellaGioia, N, Pietrzak, R H, Matuskey, D, Nabulsi, N, Abdallah, C G, Yang, J, Pittenger, C, Sanacora, G, Krystal, J H, Parsey, R V, Carson, R E, DeLorenzo, C

“…The mechanisms of action of the rapid antidepressant effects of ketamine, an N-methyl-D-aspartate glutamate receptor antagonist, have not been fully…”
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A new MRI ratio method for in-vivo estimation of signal hypointensity in aging and Alzheimer's disease by Parsey, Ramin V., Ranga, K., Krishnan, R.

“…1. 1. Alzheimer's Disease (AD) is accompanied by a disruption in iron metabolism. There is no universally accepted method for detecting brain iron. 2. 2. The…”
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Pretreatment and early-treatment cortical thickness is associated with SSRI treatment response in major depressive disorder by Bartlett, Elizabeth A, DeLorenzo, Christine, Sharma, Priya, Yang, Jie, Zhang, Mengru, Petkova, Eva, Weissman, Myrna, McGrath, Patrick J, Fava, Maurizio, Ogden, R Todd, Kurian, Benji T, Malchow, Ashley, Cooper, Crystal M, Trombello, Joseph M, McInnis, Melvin, Adams, Phillip, Oquendo, Maria A, Pizzagalli, Diego A, Trivedi, Madhukar, Parsey, Ramin V

“…To date, there are no biomarkers for major depressive disorder (MDD) treatment response in clinical use. Such biomarkers could allow for individualized…”
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Cerebral serotonin transporter measurements with [11C]DASB: A review on acquisition and preprocessing across 21 PET centres by Nørgaard, Martin, Ganz, Melanie, Svarer, Claus, Feng, Ling, Ichise, Masanori, Lanzenberger, Rupert, Lubberink, Mark, Parsey, Ramin V, Politis, Marios, Rabiner, Eugenii A, Slifstein, Mark, Sossi, Vesna, Suhara, Tetsuya, Talbot, Peter S, Turkheimer, Federico, Strother, Stephen C, Knudsen, Gitte M

“…Positron Emission Tomography (PET) imaging has become a prominent tool to capture the spatiotemporal distribution of neurotransmitters and receptors in the…”
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Volumetric Analysis of the Prefrontal Cortex, Amygdala, and Hippocampus in Major Depression by HASTINGS, Ramin S, PARSEY, Ramin V, OQUENDO, Maria A, ARANGO, Victoria, MANN, J. John

“…Magnetic resonance imaging (MRI) studies in depressed subjects report smaller volumes of amygdala, hippocampus, inferior anterior cingulate, and the orbital…”
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Biodistribution, Toxicology, and Radiation Dosimetry of 5-HT 1A -Receptor Agonist Positron Emission Tomography Ligand [ 11 C]CUMI-101 by Kumar, Dileep J. S., Bai, Bing, Ng, Hanna H., Mirsalis, Jon C., Erlandsson, Kjell, Milak, Matthew S., Majo, Vattoly J., Prabhakaran, Jaya, Mann, J. J., Parsey, R. V.

“…Sprague Dawley rats (10/sex/group) were given a single intravenous (iv) dose of CUMI-101 to determine acute toxicity of CUMI-101 and radiation dosimetry…”
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Effect of a Triallelic Functional Polymorphism of the Serotonin-Transporter-Linked Promoter Region on Expression of Serotonin Transporter in the Human Brain by Parsey, Ramin V., Hastings, Ramin S., Oquendo, Maria A., Hu, Xianzhang, Goldman, David, Huang, Yung-yu, Simpson, Norman, Arcement, Julie, Huang, Yiyun, Ogden, R. Todd, Van Heertum, Ronald L., Arango, Victoria, Mann, J. John

“…OBJECTIVE: The authors examined effects of a triallelic functional polymorphism of the human serotonin-transporter-linked promoter region (5-HTTLPR) on in vivo…”
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Multimodal classification of Dementia using functional data, anatomical features and 3D invariant shape descriptors by Mikhno, A., Nuevo, P. M., Devanand, D. P., Parsey, R. V., Laine, A. F.

“…Multimodality classification of Alzheimer's disease (AD) and its prodromal stage, Mild Cognitive Impairment (MCI), is of interest to the medical community. We…”
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