Effects of GABA and piracetam on the development of experimental cerebral infarction in rats and platelet aggregation in patients with cerebrovascular disorders

GABA and Piracetam caused the improvement of the morphological state of cerebral infarction, due to intracarotid infusion of Arachidonic acid. The effect of GABA was more pronounced. The diminishing of antiaggregatory effect of Piracetam arose in patients with acute cerebrovascular disturbances, com...

Full description

Saved in:

Bibliographic Details
Published in:	Biulleten' eksperimental'noi biologii i meditsiny Vol. 110; no. 8; p. 124
Main Authors:	Amroian, E A, Vartazarian, N D, Parsamian, L K, Balian, L S
Format:	Journal Article
Language:	Russian
Published:	Russia (Federation) 01-08-1990
Subjects:	Animals Arachidonic Acid Arachidonic Acids - administration & dosage Brain - pathology Cerebral Infarction - chemically induced Cerebral Infarction - drug therapy Cerebral Infarction - pathology Cerebrovascular Disorders - blood Cerebrovascular Disorders - drug therapy gamma-Aminobutyric Acid - pharmacology gamma-Aminobutyric Acid - therapeutic use Humans Infusions, Intra-Arterial Piracetam - pharmacology Piracetam - therapeutic use Platelet Aggregation - drug effects Platelet Aggregation Inhibitors - pharmacology Rats
Online Access:	Get more information
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	GABA and Piracetam caused the improvement of the morphological state of cerebral infarction, due to intracarotid infusion of Arachidonic acid. The effect of GABA was more pronounced. The diminishing of antiaggregatory effect of Piracetam arose in patients with acute cerebrovascular disturbances, compared with the donor group. In contrast, the antiaggregatory activity of GABA increased in the patients group. The improvement of cerebral circulation under influence of GABA can be ascribed to its rheological changes.
ISSN:	0365-9615