Utility of Atypical Lymphocytes and Large Immature Cells in Prediction of Dengue Severity

Utility of Atypical Lymphocytes and Large Immature Cells in Prediction of Dengue Severity

: There is a clinical imperative to devise metrics to prognosticate dengue severity. Our objective was to determine the association between longitudinal trends in atypical lymphocytes and large immature cell count with platelet count and dengue severity. : Retrospective analysis of longitudinally me...

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Published in:Journal of the Association of Physicians of India Vol. 71; no. 11; pp. 19 - 24
Main Authors: Peraka, Ramadevi, Koppula, Aditya, Muppala, Baby Shalini, Parsa, Mani M
Format: Journal Article
Language:English
Published: India 01-11-2023
Subjects:
Adolescent
Adult
Child
Child, Preschool
Dengue - blood
Dengue - diagnosis
Female
Humans
Leukocyte Count
Lymphocyte Count
Lymphocytes
Male
Platelet Count
Prognosis
Retrospective Studies
Severe Dengue - blood
Severe Dengue - diagnosis
Severity of Illness Index
Young Adult
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Summary:: There is a clinical imperative to devise metrics to prognosticate dengue severity. Our objective was to determine the association between longitudinal trends in atypical lymphocytes and large immature cell count with platelet count and dengue severity. : Retrospective analysis of longitudinally measured clinical and hematological data from ( = 79) hospitalized dengue patients was done. : The cohort consisted of patients with dengue fever without warning signs (DFWOWS) ( = 40, females = 14, and age = 19.9 ± 14.6 years), dengue fever with warning signs (DFWWS) ( = 36, females = 13, and age = 16.1 ± 14.1 years) and severe dengue ( = 3, females = 2, and age = 5.3 ± 4 years). Platelet count increased at a rate of 11,524 cells/mm /day, with a slower rate of rise as the severity increased ( = 0.001***). Concurrently hematocrit and neutrophil percentage decreased, while the lymphocyte percentage and white blood cell (WBC) count increased during the hospital stay. Every 1% increase in atypical lymphocyte count (ATY) was associated with a fall in platelet count by 16,963 cells/mm ( = 0.001***). A similar but weaker trend was found for large immature cells (LICs). : The data support the usefulness of longitudinal tracking of atypical lymphocyte and large immature cell count for dengue prognosis. The time trends of the hematological parameters indicate the progression of patients from the critical to the recovery phase. : Peraka R, Koppula A, Muppala BS, Utility of Atypical Lymphocytes and Large Immature Cells in Prediction of Dengue Severity. J Assoc Physicians India 2023;71(11):19-24.
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ISSN:0004-5772
DOI:10.59556/japi.71.0395