Search Results - "Parry, Richard V."

CTLA-4 and PD-1 Receptors Inhibit T-Cell Activation by Distinct Mechanisms by Parry, Richard V., Chemnitz, Jens M., Frauwirth, Kenneth A., Lanfranco, Anthony R., Braunstein, Inbal, Kobayashi, Sumire V., Linsley, Peter S., Thompson, Craig B., Riley, James L.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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The CD28 Signaling Pathway Regulates Glucose Metabolism by Frauwirth, Kenneth A, Riley, James L, Harris, Marian H, Parry, Richard V, Rathmell, Jeffrey C, Plas, David R, Elstrom, Rebecca L, June, Carl H, Thompson, Craig B

“…Lymphocyte activation initiates a program of cell growth, proliferation, and differentiation that increases metabolic demand. Although T cells increase glucose…”
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Toward the development of potent and selective bisubstrate inhibitors of protein arginine methyltransferases by Dowden, James, Hong, Wei, Parry, Richard V., Pike, Richard A., Ward, Stephen G.

“…Non-reactive amine analogues of ( S)-adenosyl methionine (AdoMet) bearing guanidine functionality were found to be potent inhibitors of PRMT1 (IC 50 of ∼3–6…”
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Phosphoinositide Lipid Phosphatases: Natural Regulators of Phosphoinositide 3-Kinase Signaling in T Lymphocytes by Harris, Stephanie J., Parry, Richard V., Westwick, John, Ward, Stephen G.

“…The phosphoinositide 3-kinase signaling pathway has been implicated in a range of T lymphocyte cellular functions, particularly growth, proliferation, cytokine…”
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SHP-1 and SHP-2 Associate with Immunoreceptor Tyrosine-Based Switch Motif of Programmed Death 1 upon Primary Human T Cell Stimulation, but Only Receptor Ligation Prevents T Cell Activation by Chemnitz, Jens M, Parry, Richard V, Nichols, Kim E, June, Carl H, Riley, James L

“…To study the cis- and trans-acting factors that mediate programmed death 1 (PD-1) signaling in primary human CD4 T cells, we constructed a chimeric molecule…”
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Protein arginine methylation: a new handle on T lymphocytes? by Parry, Richard V, Ward, Stephen G

“…Protein arginine methylation has emerged as a key regulator of signal transduction with an important role in T lymphocyte activation. The predominant methyl…”
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Small molecule inhibitors that discriminate between protein arginine N-methyltransferases PRMT1 and CARM1 by Dowden, James, Pike, Richard A, Parry, Richard V, Hong, Wei, Muhsen, Usama A, Ward, Stephen G

“…Protein arginine N-methyltransferases (PRMTs) selectively replace N-H for N-CH(3) at substrate protein guanidines, a post-translational modification important…”
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Fine tuning T lymphocytes: A role for the lipid phosphatase SHIP-1 by Parry, Richard V., Harris, Stephanie J., Ward, Stephen G.

“…The phosphoinositide 3-kinase signaling pathway regulates a range of T lymphocyte cellular functions including growth, proliferation, cytokine secretion and…”
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CD28 and Inducible Costimulatory Protein Src Homology 2 Binding Domains Show Distinct Regulation of Phosphatidylinositol 3-Kinase, Bcl-xL, and IL-2 Expression in Primary Human CD4 T Lymphocytes by Parry, Richard V, Rumbley, Catherine A, Vandenberghe, Luk H, June, Carl H, Riley, James L

“…Ligation of either CD28 or inducible costimulatory protein (ICOS) produces a second signal required for optimal T cell activation and proliferation. One…”
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Evidence that the lipid phosphatase SHIP-1 regulates T lymphocyte morphology and motility by Harris, Stephanie J, Parry, Richard V, Foster, John G, Blunt, Matthew D, Wang, Amu, Marelli-Berg, Federica, Westwick, John, Ward, Stephen G

“…SHIP-1 negatively regulates the PI3K pathway in hematopoietic cells and has an emerging role in T lymphocyte biology. PI3K and SHIP can regulate cell migration…”
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PI3Kγ is the dominant isoform involved in migratory responses of human T lymphocytes: Effects of ex vivo maintenance and limitations of non-viral delivery of siRNA by Smith, Laura D., Hickman, Emma S., Parry, Richard V., Westwick, John, Ward, Stephen G.

“…Use of mice in which individual PI3K isoforms have been deleted or mutated by gene targeting, has determined that PI3Kγ provides a key migratory signal for T…”
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Signalling to suit function: tailoring phosphoinositide 3-kinase during T-cell activation by Parry, Richard V, Riley, James L, Ward, Stephen G

“…Members of the CD28 family of co-receptors are crucial determinants of the outcome of T-cell activation. These receptors interact with ligands in the B7 family…”
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Genetic engineering of T cells for adoptive immunotherapy by Varela-Rohena, Angel, Carpenito, Carmine, Perez, Elena E., Richardson, Max, Parry, Richard V., Milone, Michael, Scholler, John, Hao, Xueli, Mexas, Angela, Carroll, Richard G., June, Carl H., Riley, James L.

“…To be effective for the treatment of cancer and infectious diseases, T cell adoptive immunotherapy requires large numbers of cells with abundant proliferative…”
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Ligation of CD28 by Its Natural Ligand CD86 in the Absence of TCR Stimulation Induces Lipid Raft Polarization in Human CD4 T Cells by Kovacs, Birgit, Parry, Richard V, Ma, Zhengyu, Fan, Emily, Shivers, Debra K, Freiberg, Benjamin A, Thomas, Anna K, Rutherford, Robert, Rumbley, Catherine A, Riley, James L, Finkel, Terri H

“…Stimulation of resting CD4 T cells with anti-CD3/CD28-coated beads leads to rapid polarization of lipid rafts (LRs). It has been postulated that a major role…”
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Ligation of CD28 Stimulates the Formation of a Multimeric Signaling Complex Involving Grb-2-Associated Binder 2 (Gab2), Src Homology Phosphatase-2, and Phosphatidylinositol 3-Kinase: Evidence That Negative Regulation of CD28 Signaling Requires the Gab2 Pleckstrin Homology Domain by Parry, Richard V, Whittaker, Gillian C, Sims, Martin, Edmead, Christine E, Welham, Melanie J, Ward, Stephen G

“…Grb-2-associated binder (Gab)2 is a scaffolding adaptor protein that has been reported to promote growth factor and cytokine receptor signal transduction, but…”
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Calcium-independent calcineurin regulation by Parry, Richard V, June, Carl H

“…Calcineurin is negatively regulated by calcipressin 1. Analysis of calcipressin-deficient mice shows that survival of T helper type 1 cells is dependent on…”
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PI3Kgamma is the dominant isoform involved in migratory responses of human T lymphocytes: effects of ex vivo maintenance and limitations of non-viral delivery of siRNA by Smith, Laura D, Hickman, Emma S, Parry, Richard V, Westwick, John, Ward, Stephen G

“…Use of mice in which individual PI3K isoforms have been deleted or mutated by gene targeting, has determined that PI3Kgamma provides a key migratory signal for…”
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Ligation of the T cell co-stimulatory receptor CD28 activates the serine-threonine protein kinase protein kinase B by Parry, R V, Reif, K, Smith, G, Sansom, D M, Hemmings, B A, Ward, S G

“…The intracellular signaling pathways activated upon ligation of the co-stimulatory receptor CD28 remain relatively ill-defined, although CD28 ligation does…”
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CTLA-4 and PD-1 Receptors Inhibit T-Cell Activation by Distinct Mechanisms by Chemnitz, Jens M., Riley, James L., Frauwirth, Kenneth A., Braunstein, Inbal, Kobayashi, Sumire V., Linsley, Peter S., Thompson, Craig B., Parry, Richard V.

“…CTLA-4 and PD-1 are receptors that negatively regulate T cell activation. Ligation of both CTLA-4 and PD-1 blocked CD3/CD28 mediated upregulation of glucose…”
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CD28 stimulates tyrosine phosphorylation, cellular redistribution and catalytic activity of the inositol lipid 5‐phosphatase SHIP by Edmunds, Catherine, Parry, Richard V., Burgess, Steven J., Reaves, Barbara, Ward, Stephen G.

“…The D‐3 phosphoinositide lipids phosphatidylinositol 3,4,5‐trisphophate [PtdIns(3,4,5)P3] and phosphatidylinositol 3,4‐bisphosphate [PtdIns(3,4)P2] represent…”
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