Search Results - "Parry, Nigel R."

Optimization of Novel Acyl Pyrrolidine Inhibitors of Hepatitis C Virus RNA-Dependent RNA Polymerase Leading to a Development Candidate by Slater, Martin J, Amphlett, Elizabeth M, Andrews, David M, Bravi, Gianpaolo, Burton, George, Cheasty, Anne G, Corfield, John A, Ellis, Malcolm R, Fenwick, Rebecca H, Fernandes, Stephanie, Guidetti, Rossella, Haigh, David, Hartley, C. David, Howes, Peter D, Jackson, Deborah L, Jarvest, Richard L, Lovegrove, Victoria L. H, Medhurst, Katrina J, Parry, Nigel R, Price, Helen, Shah, Pritom, Singh, Onkar M. P, Stocker, Richard, Thommes, Pia, Wilkinson, Claire, Wonacott, Alan

“…Optimization of a pyrrolidine-based template using structure-based design and physicochemical considerations has provided a development candidate 20b (3082)…”
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Development of Cell-Based Assays for In Vitro Characterization of Hepatitis C Virus NS3/4A Protease Inhibitors by Chung, Victoria, Carroll, Anthony R, Gray, Norman M, Parry, Nigel R, Thommes, Pia A, Viner, K Claire, D'Souza, Eric A

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Studies on acyl pyrrolidine inhibitors of HCV RNA-dependent RNA polymerase to identify a molecule with replicon antiviral activity by Burton, George, Ku, Thomas W., Carr, Thomas J., Kiesow, Terry, Sarisky, Robert T., Lin-Goerke, Juili, Hofmann, Glenn A., Slater, Martin J., Haigh, David, Dhanak, Dashyant, Johnson, Victor K., Parry, Nigel R., Thommes, Pia

“…Optimisation of a series of N-acyl pyrrolidine inhibitors of the Hepatitis C Virus RNA-dependent RNA polymerase, NS5B, from tractable enzyme inhibitors to an…”
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Rapid in vitro Selection of Human Immunodeficiency Virus Type 1 Resistant to 3'-Thiacytidine Inhibitors Due to a Mutation in the YMDD Region of Reverse Transcriptase by Tisdale, Margaret, Kemp, Sharon D., Parry, Nigel R., Larder, Brendan A.

“…Resistant variants of human immunodeficiency virus type 1 (HIV-1) have been selected by limited passage in MT4 cells of both wild-type and…”
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Design and Synthesis of Pyrrolidine-5,5‘-trans-Lactams (5-Oxo-hexahydropyrrolo[3,2-b]pyrroles) as Novel Mechanism-Based Inhibitors of Human Cytomegalovirus Protease. 4. Antiviral Activity and Plasma Stability by Borthwick, Alan D, Davies, Dave E, Ertl, Peter F, Exall, Anne M, Haley, Terry M, Hart, Graham J, Jackson, Deborah L, Parry, Nigel R, Patikis, Angela, Trivedi, Naimisha, Weingarten, Gordon G, Woolven, James M

“…A series of chiral, (S)-proline-α-methylpyrrolidine-5,5-trans-lactam serine protease inhibitors has been developed as antivirals of human cytomegalovirus…”
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Pyrrolidine-5,5-trans-lactams. 4. Incorporation of a P3/P4 Urea Leads to Potent Intracellular Inhibitors of Hepatitis C Virus NS3/4A Protease by Slater, Martin J, Amphlett, Elizabeth M, Andrews, David M, Bamborough, Paul, Carey, Seb J, Johnson, Martin R, Jones, Paul S, Mills, Gail, Parry, Nigel R, Stewart, Alan J, Skarzynski, Tadeusz

“…In this, the first of two Letters, we describe how a P3/P4 urea linking unit was used to greatly enhance the biochemical and replicon potency of inhibitors…”
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1592U89, a novel carbocyclic nucleoside analog with potent, selective anti-human immunodeficiency virus activity by DALUGE, S. M, GOOD, S. S, AVERETT, D. R, KRENITSKY, T. A, FALETTO, M. B, MILLER, W. H, CLAIR, M. H. S, BOONE, L. R, TISDALE, M, PARRY, N. R, REARDON, J. E, DORNSIFE, R. E

“…Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon…”
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Regression of Canine Oral Papillomas Is Associated with Infiltration of CD4+ and CD8+ Lymphocytes by Nicholls, Philip K., Moore, Peter F., Anderson, Davina M., Moore, Richard A., Parry, Nigel R., Gough, Gerald W., Stanley, Margaret A.

“…Canine oral papillomavirus (COPV) infection is used in vaccine development against mucosal papillomaviruses. The predictable, spontaneous regression of the…”
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Naturally Occurring, Nonregressing Canine Oral Papillomavirus Infection: Host Immunity, Virus Characterization, and Experimental Infection by Nicholls, Philip K., Klaunberg, Brenda A., Moore, Richard A., Santos, Elmer B., Parry, Nigel R., Gough, Gerald W., Stanley, Margaret A.

“…Papillomaviruses occasionally cause severe, nonregressing or recurrent infections in their human and animal hosts. The mechanisms underlying these atypical…”
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Development of cell-based assays for in vitro characterization of gepatitis C Virus NS3/4A Protease Inhibitors by CHUNG, Victoria, CARROLL, Anthony R, GRAY, Norman M, PARRY, Nigel R, THOMMES, Pia A, VINER, K. Claire, D'SOUZA, Eric A

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Crystal structure of a human rhinovirus neutralizing antibody complexed with a peptide derived from viral capsid protein VP2 by Tormo, J., Blaas, D., Parry, N.R., Rowlands, D., Stuart, D., Fita, I.

“…The three‐dimensional structure of the complex between the Fab fragment of an anti‐human rhinovirus neutralizing antibody (8F5) and a cross‐reactive synthetic…”
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cell attachment site on foot-and-mouth disease virus includes the amino acid sequence RGD (arginine-glycine-aspartic acid) by Fox, G, Parry, N.R, Barnett, P.V, McGinn, B, Rowlands, D.J, Brown, F

“…1 Wellcome Biotechnology Ltd, Ash Road, Pirbright, Surrey GU24 0NQ and 2 Wellcome Biotechnology Ltd, Langley Court, Beckenham, Kent BR3 3BS, U.K. The amino…”
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Synthesis and antiviral activity of acyclovir-5'-(phenyl methoxy alaninyl) phosphate as a possible membrane-soluble nucleotide prodrug by MCGUIGAN, C, SLATER, M. J, PARRY, N. R, PERRY, A, HARRIS, S

“…We describe a synthesis of acyclovir-5'-(phenyl methoxy alaninyl) phosphate (2) from acyclovir (1). This compound was designed to act as a lipophilic,…”
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Rescue, expression, and analysis of a neutralizing human anti-hepatitis A virus monoclonal antibody by Lewis, AP, Lemon, SM, Barber, KA, Murphy, P, Parry, NR, Peakman, TC, Sims, MJ, Worden, J, Crowe, JS

“…A human anti-hepatitis A virus mAb was rescued from a hybridoma cell line by conventional cDNA cloning, and expressed in CHO cells. The full nucleotide…”
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