Search Results - "Parrott, Jennifer M"

Kynurenine pathway metabolic balance influences microglia activity: Targeting kynurenine monooxygenase to dampen neuroinflammation by Garrison, Allison M., Parrott, Jennifer M., Tuñon, Arnulfo, Delgado, Jennifer, Redus, Laney, O’Connor, Jason C.

“…•KMO inhibition attenutates specific elements of microglia activation.•Primary KMO -/- microglia recapitulate pharmacologic inhibition of KMO.•Kynurenine…”
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Kynurenine metabolic balance is disrupted in the hippocampus following peripheral lipopolysaccharide challenge by Parrott, Jennifer M, Redus, Laney, O'Connor, Jason C

“…Inflammation increases the risk of developing depression-related symptoms, and tryptophan metabolism is an important mediator of these behavior changes…”
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Intracerebroventricular administration of lipopolysaccharide induces indoleamine-2,3-dioxygenase-dependent depression-like behaviors by Lawson, Marcus A, Parrott, Jennifer M, McCusker, Robert H, Dantzer, Robert, Kelley, Keith W, O'Connor, Jason C

“…Activation of the tryptophan degrading enzyme indoleamine-2,3-dioxygenase 1 (IDO1) is associated with the development of behavioral signs of depression…”
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Altered inflammatory response in FMRP-deficient microglia by Parrott, Jennifer M., Oster, Thomas, Lee, Hye Young

“…Fragile X syndrome (FXS) is an inherited intellectual disability with a high risk for comorbid autism spectrum disorders. Since FXS is a genetic disease,…”
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Kynurenine 3-Monooxygenase: An Influential Mediator of Neuropathology by Parrott, Jennifer M, O'Connor, Jason C

“…Mounting evidence demonstrates that kynurenine metabolism may play an important pathogenic role in the development of multiple neurological and…”
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Brain derived neurotrophic factor deficiency exacerbates inflammation-induced anhedonia in mice by Parrott, Jennifer M., Porter, Grace A., Redus, Laney, O’Connor, Jason C.

“…Brain-derived neurotrophic factor (BDNF) is implicated in the pathology of major depression and influences the inflammatory response. Prolonged immune system…”
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Hypothesis‐driven investigations of diverse pharmacological targets in two mouse models of autism by Rhine, Maya A., Parrott, Jennifer M., Schultz, Maria N., Kazdoba, Tatiana M., Crawley, Jacqueline N.

“…Autism spectrum disorder is a neurodevelopmental syndrome diagnosed primarily by persistent deficits in social interactions and communication, unusual sensory…”
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Author response to: Modulating kynurenine monooxygenase in microglia: The need for further characterization by Garrison, Allison M., Parrott, Jennifer M., Tunon, Arnulfo, Delgado, Jennifer, Redus, Laney, O’Connor, Jason C.

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Indoleamine 2,3-dioxygenase mediates anhedonia and anxiety-like behaviors caused by peripheral lipopolysaccharide immune challenge by Salazar, Alexander, Gonzalez-Rivera, Bryan L., Redus, Laney, Parrott, Jennifer M., O'Connor, Jason C.

“…This article is part of a Special Issue “Neuroendocrine-Immune Axis in Health and Disease.” Upregulation of indoleamine 2,3-dioxygenase (IDO) by…”
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Low-Level Stress Induces Production of Neuroprotective Factors in Wild-Type but Not BDNF+/- Mice: Interleukin-10 and Kynurenic Acid by Dugan, Allison M., Parrott, Jennifer M., Redus, Laney, Hensler, Julie G., O’Connor, Jason C.

“…Background: Brain-derived neurotrophic factor (BDNF) deficiency confers vulnerability to stress, but the mechanisms are unclear. BDNF+/- mice exhibit…”
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Low-Level Stress Induces Production of Neuroprotective Factors in Wild-Type but Not BDNF super(+/-) Mice: Interleukin-10 and Kynurenic Acid by Dugan, Allison M, Parrott, Jennifer M, Redus, Laney, Hensler, Julie G, O'connor, Jason C

“…Background: Brain-derived neurotrophic factor (BDNF) deficiency confers vulnerability to stress, but the mechanisms are unclear. BDNF super(+/-) mice exhibit…”
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