Search Results - "Parras, Alberto"

Impaired development of neocortical circuits contributes to the neurological alterations in DYRK1A haploinsufficiency syndrome by Arranz, Juan, Balducci, Elisa, Arató, Krisztina, Sánchez-Elexpuru, Gentzane, Najas, Sònia, Parras, Alberto, Rebollo, Elena, Pijuan, Isabel, Erb, Ionas, Verde, Gaetano, Sahun, Ignasi, Barallobre, Maria J., Lucas, José J., Sánchez, Marina P., de la Luna, Susana, Arbonés, Maria L.

“…Autism spectrum disorders are early onset neurodevelopmental disorders characterized by deficits in social communication and restricted repetitive behaviors,…”
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Initiation phase cellular reprogramming ameliorates DNA damage in the ERCC1 mouse model of premature aging by Paine, Patrick Treat, Rechsteiner, Cheyenne, Morandini, Francesco, Desdín-Micó, Gabriela, Mrabti, Calida, Parras, Alberto, Haghani, Amin, Brooke, Robert, Horvath, Steve, Seluanov, Andrei, Gorbunova, Vera, Ocampo, Alejandro

“…Unlike aged somatic cells, which exhibit a decline in molecular fidelity and eventually reach a state of replicative senescence, pluripotent stem cells can…”
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In vivo reprogramming leads to premature death linked to hepatic and intestinal failure by Parras, Alberto, Vílchez-Acosta, Alba, Desdín-Micó, Gabriela, Picó, Sara, Mrabti, Calida, Montenegro-Borbolla, Elena, Maroun, Céline Yacoub, Haghani, Amin, Brooke, Robert, del Carmen Maza, María, Rechsteiner, Cheyenne, Battiston, Fabrice, Branchina, Clémence, Perez, Kevin, Horvath, Steve, Bertelli, Claire, Sempoux, Christine, Ocampo, Alejandro

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DNA repair‐deficient premature aging models display accelerated epigenetic age by Perez, Kevin, Parras, Alberto, Picó, Sara, Rechsteiner, Cheyenne, Haghani, Amin, Brooke, Robert, Mrabti, Calida, Schoenfeldt, Lucas, Horvath, Steve, Ocampo, Alejandro

“…Several premature aging mouse models have been developed to study aging and identify interventions that can delay age‐related diseases. Yet, it is still…”
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The P2X7 receptor contributes to seizures and inflammation‐driven long‐lasting brain hyperexcitability following hypoxia in neonatal mice by Smith, Jonathon, Menéndez Méndez, Aida, Alves, Mariana, Parras, Alberto, Conte, Giorgia, Bhattacharya, Anindya, Ceusters, Marc, Nicke, Annette, Henshall, David C., Jimenez‐Mateos, Eva M., Engel, Tobias

“…Background and Purpose Neonatal seizures represent a clinical emergency. However, current anti‐seizure medications fail to resolve seizures in ~50% of infants…”
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High concordance between hippocampal transcriptome of the mouse intra‐amygdala kainic acid model and human temporal lobe epilepsy by Conte, Giorgia, Parras, Alberto, Alves, Mariana, Ollà, Ivana, De Diego‐Garcia, Laura, Beamer, Edward, Alalqam, Razi, Ocampo, Alejandro, Mendez, Raúl, Henshall, David C., Lucas, José J., Engel, Tobias

“…Objective Pharmacoresistance and the lack of disease‐modifying actions of current antiseizure drugs persist as major challenges in the treatment of epilepsy…”
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Pathogenic Mis-splicing of CPEB4 in Schizophrenia by Ollà, Ivana, Pardiñas, Antonio F., Parras, Alberto, Hernández, Ivó H., Santos-Galindo, María, Picó, Sara, Callado, Luis F., Elorza, Ainara, Rodríguez-López, Claudia, Fernández-Miranda, Gonzalo, Belloc, Eulàlia, Walters, James T.R., O’Donovan, Michael C., Méndez, Raúl, Toma, Claudio, Meana, J. Javier, Owen, Michael J., Lucas, José J.

“…Schizophrenia (SCZ) is caused by an interplay of polygenic risk and environmental factors, which may alter regulators of gene expression leading to pathogenic…”
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Opposing effects of the purinergic P2X7 receptor on seizures in neurons and microglia in male mice by Alves, Mariana, Gil, Beatriz, Villegas-Salmerón, Javier, Salari, Valentina, Martins-Ferreira, Ricardo, Arribas Blázquez, Marina, Menéndez Méndez, Aida, Da Rosa Gerbatin, Rogerio, Smith, Jonathon, de Diego-Garcia, Laura, Conte, Giorgia, Sierra-Marquez, Juan, Merino Serrais, Paula, Mitra, Meghma, Fernandez Martin, Ana, Wang, Yitao, Kesavan, Jaideep, Melia, Ciara, Parras, Alberto, Beamer, Edward, Zimmer, Béla, Heiland, Mona, Cavanagh, Brenton, Parcianello Cipolat, Rafael, Morgan, James, Teng, Xinchen, Prehn, Jochen H.M., Fabene, Paolo F., Bertini, Giuseppe, Artalejo, Antonio R., Ballestar, Esteban, Nicke, Annette, Olivos-Oré, Luis A., Connolly, Niamh M.C., Henshall, David C., Engel, Tobias

“…•P2X7R signaling regulates both glial and neuronal genes during seizures.•P2X7R deficiency in microglia reduces seizure severity and leads to an…”
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Polyadenylation of mRNA as a novel regulatory mechanism of gene expression in temporal lobe epilepsy by Parras, Alberto, de Diego-Garcia, Laura, Alves, Mariana, Beamer, Edward, Conte, Giorgia, Jimenez-Mateos, Eva M, Morgan, James, Ollà, Ivana, Hernandez-Santana, Yasmina, Delanty, Norman, Farrell, Michael A, O'Brien, Donncha F, Ocampo, Alejandro, Henshall, David C, Méndez, Raúl, Lucas, José J, Engel, Tobias

“…Temporal lobe epilepsy is the most common and refractory form of epilepsy in adults. Gene expression within affected structures such as the hippocampus…”
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I03 CPEB alteration and aberrant transcriptome-polyadenylation unveil a treatable vitamin B1 deficiency in huntington’s disease by Pico, Sara, Parras, Alberto, Santos-Galindo, María, Pose-Utrilla, Julia, Castro, Margarita, Fraga, Enrique, Hernández, Ivó H, Elorza, Ainara, Anta, Héctor, Wang, Nan, Martí-Sánchez, Laura, Belloc, Eulàlia, Garcia-Esparcia, Paula, Garrido, Juan J, Ferrer, Isidro, Macías-García, Daniel, Mir, Pablo, Artuch, Rafael, Pérez, Belén, Hernández, Félix, Navarro, Pilar, López-Sendón, José Luis, Iglesias, Teresa, William Yang, X, Méndez, Raúl, Lucas, José J

“…BackgroundAlthough promising gene-silencing therapies are being tested for Huntington’s disease (HD), no disease-modifying treatments are available. Thus,…”
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CPEB alteration and aberrant transcriptome-polyadenylation lead to a treatable SLC19A3 deficiency in Huntington's disease by Picó, Sara, Parras, Alberto, Santos-Galindo, María, Pose-Utrilla, Julia, Castro, Margarita, Fraga, Enrique, Hernández, Ivó H, Elorza, Ainara, Anta, Héctor, Wang, Nan, Martí-Sánchez, Laura, Belloc, Eulàlia, Garcia-Esparcia, Paula, Garrido, Juan J, Ferrer, Isidro, Macías-García, Daniel, Mir, Pablo, Artuch, Rafael, Pérez, Belén, Hernández, Félix, Navarro, Pilar, López-Sendón, José Luis, Iglesias, Teresa, Yang, X William, Méndez, Raúl, Lucas, José J

“…Huntington’s disease (HD) is a hereditary neurodegenerative disorder of the basal ganglia for which disease-modifying treatments are not yet available…”
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CPEB4 - CLOCK crosstalk during temporal lobe epilepsy by de Diego-Garcia, Laura, Brennan, Gary P, Auer, Theresa, Menendez-Mendez, Aida, Parras, Alberto, Martin-Gil, Alba, Mitra, Meghma, Ollà, Ivana, Villalba-Benito, Leticia, Gil, Beatriz, Alves, Mariana, Lau, Kelvin, Delanty, Norman, Beausang, Alan, Cryan, Jane, Brett, Francesca M, Farrell, Michael A, O'Brien, Donncha F, Mendez, Raúl, Carracedo-Rodríguez, Gonzalo, Henshall, David C, Lucas, José J, Engel, Tobias

“…Post-transcriptional mechanisms are increasingly recognized as important contributors to the formation of hyperexcitable networks in epilepsy. Messenger RNA…”
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In vivo reprogramming leads to premature death linked to hepatic and intestinal failure by Parras, Alberto, Vílchez-Acosta, Alba, Desdín-Micó, Gabriela, Picó, Sara, Mrabti, Calida, Montenegro-Borbolla, Elena, Maroun, Céline Yacoub, Haghani, Amin, Brooke, Robert, Del Carmen Maza, María, Rechsteiner, Cheyenne, Battiston, Fabrice, Branchina, Clémence, Perez, Kevin, Horvath, Steve, Bertelli, Claire, Sempoux, Christine, Ocampo, Alejandro

“…The induction of cellular reprogramming via expression of the transcription factors Oct4, Sox2, Klf4 and c-Myc (OSKM) can drive dedifferentiation of somatic…”
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Autism-like phenotype and risk gene mRNA deadenylation by CPEB4 mis-splicing by Parras, Alberto, Anta, Héctor, Santos-Galindo, María, Swarup, Vivek, Elorza, Ainara, Nieto-González, José L., Picó, Sara, Hernández, Ivó H., Díaz-Hernández, Juan I., Belloc, Eulàlia, Rodolosse, Annie, Parikshak, Neelroop N., Peñagarikano, Olga, Fernández-Chacón, Rafael, Irimia, Manuel, Navarro, Pilar, Geschwind, Daniel H., Méndez, Raúl, Lucas, José J.

“…Common genetic contributions to autism spectrum disorder (ASD) reside in risk gene variants that individually have minimal effect sizes. As environmental…”
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Autism-like phenotype and risk gene-RNA deadenylation by CPEB4 mis-splicing by Parras, Alberto, Anta, Héctor, Santos-Galindo, María, Swarup, Vivek, Elorza, Ainara, Nieto-Gonzalez, José L., Picó, Sara, Hernández, Ivó H., Díaz-Hernández, Juan I., Belloc, Eulàlia, Rodolosse, Annie, Parikshak, Neelroop N., Peñagarikano, Olga, Fernández-Chacón, Rafael, Irimia, Manuel, Navarro, Pilar, Geschwind, Daniel H., Méndez, Raúl, Lucas, José J.

“…Common genetic contributions to autism spectrum disorder (ASD) reside in risk-gene variants that individually have minimal effect-sizes. Since…”
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