Search Results - "Parra, Leonardo A"

A Biochemical and Functional Protein Complex Involving Dopamine Synthesis and Transport into Synaptic Vesicles by Cartier, Etienne A., Parra, Leonardo A., Baust, Tracy B., Quiroz, Marisol, Salazar, Gloria, Faundez, Victor, Egaña, Loreto, Torres, Gonzalo E.

“…Synaptic transmission depends on neurotransmitter pools stored within vesicles that undergo regulated exocytosis. In the brain, the vesicular monoamine…”
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Synapsin E-domain is essential for α-synuclein function by Stavsky, Alexandra, Parra-Rivas, Leonardo A, Tal, Shani, Riba, Jen, Madhivanan, Kayalvizhi, Roy, Subhojit, Gitler, Daniel

“…The cytosolic proteins synucleins and synapsins are thought to play cooperative roles in regulating synaptic vesicle (SV) recycling, but mechanistic insight is…”
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In Vivo Analysis of a Gain-of-Function Mutation Confirms Unc18/Munc18's Role in Priming by Parra, Leonardo A

“…Parra presents an in vivo analysis of a gain-of-function mutation which confirms Unc18/Munc18's role in priming. The Unc18 proteins act during calcium-mediated…”
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Evaluation of Overground Endoscopy Findings in Colombian Criollo Paso Horses by Joó, Kinga, Duque Betancourt, Diego, Vasquez Marin, Tomas, Parra Moyano, Leonardo A.

“…The dynamic upper airway functional (URT) problems of Colombian paso horses (CPH) have not been investigated in literature up to date. These horses perform…”
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The orphan transporter Rxt1/NTT4 (SLC6A17) functions as a synaptic vesicle amino acid transporter selective for proline, glycine, leucine, and alanine by Parra, Leonardo A, Baust, Tracy, El Mestikawy, Salah, Quiroz, Marisol, Hoffman, Beth, Haflett, Jack M, Yao, Jeffrey K, Torres, Gonzalo E

“…Rxt1/NTT4 (SLC6A17) belongs to a gene family of "orphan transporters" whose substrates and consequently functions remain unidentified. Although Rxt1/NTT4 was…”
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The Molecular Chaperone Hsc70 Interacts with Tyrosine Hydroxylase to Regulate Enzyme Activity and Synaptic Vesicle Localization by Parra, Leonardo A., Baust, Tracy B., Smith, Amanda D., Jaumotte, Juliann D., Zigmond, Michael J., Torres, Soledad, Leak, Rehana K., Pino, Jose A., Torres, Gonzalo E.

“…We previously reported that the vesicular monoamine transporter 2 (VMAT2) is physically and functionally coupled with Hsc70 as well as with the dopamine…”
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Physical and Functional Interaction between the Dopamine Transporter and the Synaptic Vesicle Protein Synaptogyrin-3 by Egana, Loreto A, Cuevas, Rolando A, Baust, Tracy B, Parra, Leonardo A, Leak, Rehana K, Hochendoner, Sarah, Pena, Karina, Quiroz, Marisol, Hong, Weimin C, Dorostkar, Mario M, Janz, Roger, Sitte, Harald H, Torres, Gonzalo E

“…Uptake through the dopamine transporter (DAT) represents the primary mechanism used to terminate dopaminergic transmission in brain. Although it is well known…”
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Serine-129 phosphorylation of α-synuclein is an activity-dependent trigger for physiologic protein-protein interactions and synaptic function by Parra-Rivas, Leonardo A, Madhivanan, Kayalvizhi, Aulston, Brent D, Wang, Lina, Prakashchand, Dube Dheeraj, Boyer, Nicholas P, Saia-Cereda, Veronica M, Branes-Guerrero, Kristen, Pizzo, Donald P, Bagchi, Pritha, Sundar, V S, Tang, Yong, Das, Utpal, Scott, David A, Rangamani, Padmini, Ogawa, Yuki, Subhojit Roy

“…Phosphorylation of α-synuclein at the serine-129 site (α-syn Ser129P) is an established pathologic hallmark of synucleinopathies and a therapeutic target. In…”
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The molecular chaperone Hsc70 interacts with the vesicular monoamine transporter‐2 by Requena, Daniela F., Parra, Leonardo A., Baust, Tracy B., Quiroz, Marisol, Leak, Rehana K., Garcia‐Olivares, Jennie, Torres, Gonzalo E.

“…Synaptic transmission depends on the efficient loading of transmitters into synaptic vesicles by vesicular neurotransmitter transporters. The vesicular…”
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Uso de N-butilbromuro de hioscina en premedicación anestésica en un equino con un bloqueo atrioventricular Mobitz tipo II by Parra M., Leonardo A., Flórez, María Alejandra, Lenis, Santiago, Arango, Laura, Marín, Juliana, Ruiz, Santiago, Rojas, Daniela, Calle, Valentina

“…El bloqueo atrioventricular (AV) segundo grado Mobitz tipo II, a diferencia del bloqueo Mobitz tipo I, se caracteriza por presentar un intervalo PR normal…”
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Interspecies complementation identifies a pathway to assemble SNAREs by Parra-Rivas, Leonardo A., Palfreyman, Mark T., Vu, Thien N., Jorgensen, Erik M.

“…Unc18 and SNARE proteins form the core of the membrane fusion complex at synapses. To understand the functional interactions within the core machinery, we…”
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In vivo safety and efficacy of a CRISPR‐based gene therapy for Alzheimer’s disease by Aulston, Brent D, Branes, Kristen, Checka, Nidhi, Parra‐Rivas, Leonardo A, Roy, Subhojit

“…Background Our lab has developed a gene‐editing strategy to target the extreme C‐terminus (C‐term) of APP (amyloid precursor protein) – a gene with a central…”
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Synapsin E-domain is essential for α-synuclein function by Stavsky, Alexandra, Parra-Rivas, Leonardo A, Tal, Shani, Riba, Jen, Madhivanan, Kayalvizhi, Roy, Subhojit, Gitler, Daniel

“…The cytosolic proteins synucleins and synapsins are thought to play cooperative roles in regulating synaptic vesicle (SV) recycling, but mechanistic insight is…”
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Synapsin E-domain is essential for [alpha]-synuclein function by Stavsky, Alexandra, Parra-Rivas, Leonardo A, Tal, Shani, Riba, Jen, Madhivanan, Kayalvizhi, Roy, Subhojit, Gitler, Daniel

“…The cytosolic proteins synucleins and synapsins are thought to play cooperative roles in regulating synaptic vesicle (SV) recycling, but mechanistic insight is…”
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Dissection of alpha‐synuclein specific synaptic functions by gene editing by Madhivanan, Kayalvizhi, Parra‐Rivas, Leonardo A, Joensuu, Merja, Sanders, Shanley, Caballero‐Florán, René, Bingham, Dominic, Sharma, Rohan, Jenkins, Paul M, Leterrier, Christophe, Meunier, Frederic A, Roy, Subhojit

“…Background Despite almost two decades of research, the physiologic role of α‐synuclein remains unclear. Mice lacking α‐syn only show mild phenotypes, and most…”
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Serine‐129 phosphorylation of α‐synuclein is a trigger for physiologic protein‐protein interactions and synaptic function by Parra‐Rivas, Leonardo A, Madhivanan, Kayalvizhi, Wang, Lina, Boyer, Nicholas P, Prakashchand, Dube D, Aulston, Brent D, Branes‐Guerrero, Kristen, Rangamani, Padmini, Roy, Subhojit

“…Background α‐Synuclein (α‐syn) phosphorylation at the Serine‐129 (Ser129P) residue is a recognized pathologic hallmark of PD. Though only ∼4% of α‐syn is…”
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Defectos de nacimiento del tracto digestivo y genitourinario en dos caballos criollos colombianos: reporte de caso by Parra, Leonardo A, Duque, Diego, Garavito, A

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Equine Fibrous histiocytic sarcoma and nasal adenocarcinoma: a case report by Moyano, Leonardo A Parra, Vanegas, Viviana E Castillo, Barbosa, Katherinie Tiuso, Medina, Lorena Gutiérrez, Mahecha, Manuel A

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Sarcoma fibroso histiocitico y adenocarcinoma nasal en un equino: un reporte de caso by Parra Moyano, Leonardo A, Castillo Vanegas, Viviana E, Tiuso Barbosa, Katherinie, Gutiérrez Medina, Lorena, Mahecha, Manuel A

“…El sarcoma fibroso histiocítico y el adenocarcinoma son neoplasias malignas, localmente invasivas, que pueden generar metástasis a través del drenaje de…”
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Carcinoma de Glándula Mamaria en una Yegua Criolla Colombiana. Reporte de caso by Parra, Leonardo Adolfo, Paredes, Maria del Pilar

“…Los tumores mamarios son poco frecuente en equinos; Se han reportado prevalenciasentre 0,11% y 2%, en plantas de beneficio; en Colombia no hay estudios que…”
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